孙慧涌，博士，特聘副研究员，硕士研究生导师。2015年毕业于苏州大学功能纳米与软物质研究院（FUNSOM），获博士学位，随后加入浙江大学药学院从事博士后研究，主要研究方向为计算机辅助药物设计。迄今发表SCI论文60余篇（包括第一或通讯作者论文20余篇）。6篇第一作者论文入选ESI或扩展ESI高被引用论文，论文引用总数超过2800次。相关的第一或通讯作者论文发表于Chemical Reviews、Journal of Chemical Theory and Computation、PLoS Computational Biology、Bioinformatics、Briefings in Bioinformatics、Drug Discovery Today、Journal of Chemical Information and Modeling、British Journal of Pharmacology等本行业重要期刊中。担任Journal of Chemical Information and Modeling（IF=4.549）青年编委及Frontiers in Molecular Biosciences（IF=4.188）特刊编委。
主要研究方向：
（1）基于分子模拟技术的药物发现与机制分析
（2）基于人工智能技术的药物设计
联系方式
huiyongsun@cpu.edu.cn
代表性论文：
Ercheng Wang^#, Huiyong Sun^#(co-first author), Junmei Wang, Zhe Wang, Hui Liu, John Z.H. Zhang*, Tingjun Hou*, End-Point binding free energy calculation with MM/PBSA and MM/GBSA: strategies and applications in drug design, Chemical Reviews, 2019, 119, 9478-9508. (cover story,faculty of 1000,IF=52.758)
Jike Wang, Dongsheng Cao, Cunchen Tang, Xi Chen*, Huiyong Sun*, Tingjun Hou*, Fast and Accurate Prediction of Partial Charges Using Atom-Path-Descriptor-based Machine Learning, Bioinformatics, 2020, in press. (IF=5.610)
Jike Wang, Dongsheng Cao, Cunchen Tang, Lei Xu, Qiaojun He, Bo Yang, Xi Chen*, Huiyong Sun*, Tingjun Hou*, DeepAtomicCharge: A New Graph Convolution Network-based Architecture for Accurate Prediction of Atomic Charges,Briefings in Bioinformatics, 2020,in press. (IF=8.990)
Yangshun Tang^#, Bo Feng^#, Yi Wang^#, Huiyong Sun^#(co-first author), Yi You, Jie Yu, Bin Chen, Cenglin Xu, Yeping Ruan, Sunliang Cui, Gang Hu, Tingjun Hou*, Zhong Chen*, Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility, British Journal of Pharmacology, 2020, 177, 3519-3534. (IF=7.730)
Lei Xu^#, Xiaoqin Ding^#, Tianhu Wang^#, Shanzhi Mou, Huiyong Sun*, Tingjun Hou*, Voltage-Gated Sodium Channels: Structures, Functions and Molecular Modeling, Drug Discovery Today, 2019, 24, 1389-1397. (IF=7.321)
Huiyong Sun, Lili Duan, Fu Chen, Hui Liu, Zhe Wang, Peichen Pan, Dan Li, Feng Zhu, John Z.H. Zhang, Tingjun Hou*, Assessing the performance of MM/PBSA and MM/GBSA methods. 7. Entropy effects on the performance of end-point binding free energy calculation approaches, Physical Chemistry Chemical Physics, 2018, 20, 14450-14460.(ESI high-cited paper,IF=3.567)
Huiyong Sun, Youyong Li, Mingyun Shen, Dan Li, Yu Kang, Tingjun Hou*,Characterizing Drug-Target Residence Time with Metadynamics: How to Achieve Dissociation Rate Efficiently without Losing Accuracy against Time-Consuming Approaches, Journal of Chemical Information and Modeling,2017, 57, 1895-1906.(IF=3.804)
Huiyong Sun^#, Pengcheng Chen^#, Dan Li, Youyong Li, Tingjun Hou*, Directly Binding Rather than Induced-Fit Dominated Binding Affinity Difference in (S)- and (R)-Crizotinib Bound MTH1, Journal of Chemical Theory and Computation, 2016, 12, 851-860. (IF=5.245)
Huiyong Sun, Youyong Li, Sheng Tian, Junmei Wang, Tingjun Hou*, P-loop Conformation Governed Crizotinib Resistance in G2032R-Mutated ROS1 Tyrosine Kinase: Clues from Free Energy Landscape, PLoS Computational Biology, 2014, 10, e**. (extended ESI high-cited paper, IF=4.620)
Huiyong Sun,Tingjun Hou*, Hongyu Zhang*, Finding chemical drugs for genetic diseases, Drug Discovery Today, 2014, 19, 1836-1840. (feature article,IF=6.691)