袁浩亮，博士，副研究员，硕士生导师。2004年至2014年本科、硕士、博士均就读于中国药科大学，获药物化学专业博士学位。2015年进入中国药科大学药物科学研究院新药研究中心工作至今。主持国家自然科学基金面上项目一项、青年项目一项、中央高校基本科研业务费项目一项，另参与多项国家或省部级科研项目。申请国内专利4项，PCT专利1项，以第一作者/通讯作者发表SCI论文16篇。
研究方向：计算机辅助药物分子发现及新药研究
联系方式：Tel/fax：；E-mail：yhl@cpu.edu.cn
通讯地址：江苏省南京市鼓楼区童家巷24号，中国药科大学，科研大楼1805室，邮编：210009
代表性论文：
(1) Shengjie Liu, Xinyu Zhou, Minglei Li, Wenfeng Zhao, Shuxi Zhou, Ke-guang CHENG, Qing-Long Xu, Caiping Chen, Xiaoan Wen, Hongbin Sun*, Haoliang Yuan*. Discovery of Ubiquitin Specific Protease 7 (USP7) Inhibitors with A Novel Scaffold Structure by Virtual Screening, Molecular Dynamics Simulation and Biological Evaluation. J. Chem. Inf. Model, 2020, 60, (6): 3255–3264.
(2) Liang Dai#, Zhiqi Feng#, Rili Zha, Keguang Cheng, Xiaoan Wen, Hongbin Sun*, Haoliang Yuan*. Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation. J. Chem. Inf. Model, 2020, 60(3): 1717-1727.
(3) Xiangying Zhang, Hongbin Sun, Xiaoan Wen*,Haoliang Yuan*. A Selectivity Study of FFAR4/FFAR1 Agonists by Molecular Modeling. J. Chem. Inf. Model.2019, 59(10): 4467-4474.
(4) Haoliang Yuan#, Qiufeng Liu#, Li Zhang#, Shihe Hu, Tiantian Chen, Huifang Li, Yadong Chen, Yechun Xu*, Tao Lu*. Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors. Eur. J. Med. Chem. 2018,143, 491-502.
(5) Libo Yan, Li Zhang, Yanmin Zhang, Xin Qiao, Jing Pan, Haichun Liu, Shuai Lu, Bingren Xiang, Tao Lu*, Haoliang Yuan*.Insight into the Key Features for Ligand Binding in Y1230 Mutated C-Met Kinase Domain by Molecular Dynamics Simulations. J. Biomol. Struct. Dyn.,2018, 36:2015-2031.
(6) Yongzhi Chang，Shuxi Zhou，Enqin Li，Wenfeng Zhao，Yanpeng Ji，Xiaoan Wen*，Hongbin Sun*，Haoliang Yuan*. Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors，Eur. J. Med. Chem., 2017, 126: 143-153.
(7) Zhuang Song#，Cai-Ping Chen#，Jun Liu，Xiaoan Wen，Hongbin Sun*，Haoliang Yuan*. Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis, Eur. J. Med. Chem., 2016, 124: 809-819.
(8) Haoliang Yuan, Jin Zhuang, Shihe Hu, Huifang Li, Jinxing Xu, Yaning Hu, Xiao Xiong, Yadong Chen* and Tao Lu*. Molecular Modeling of Exquisitely Selective c-Met Inhibitors through 3D-QSAR and Molecular Dynamics Simulations J. Chem. Inf. Model., 2014, 54 (9), 2544–2554.
(9) Haoliang Yuan#, Wenting Tai#, Shihe Hu, Haichun Liu, Yanmin Zhang, Sihui Yao, Ting Ran, Shuai Lu, Zhipeng Ke, Xiao Xiong, Jinxing Xu, Yadong Chen* and Tao Lu*. Fragment-based Strategy for Structural Optimization in Combination with 3D-QSAR.J. Comput. Aided Mol. Des.2013, 27(10):897-915.
(10) Haoliang Yuan, Tao Lu, Ting Ran, Haichun Liu, Shuai Lu, Wenting Tai, Ying Leng, Weiwei Zhang, Jian Wang, Yadong Chen*. Novel strategy for three-dimensional fragment-based lead discovery. J. Chem. Inf. Model.,2011, 51 (4): 959-974.