褚钱，博士，特聘研究员，博士生导师。2001至2008年在南京大学化学化工学院完成本科和硕士学习。2014年毕业于美国哈佛大学（Harvard University）化学与化学生物学系，获博士学位（导师：Gregory Verdine教授）研究方向为化学修饰的多肽类潜在药物。2014年至2020年在美国索尔克研究所（Salk Institute for Biological Studies）Alan Saghatelian教授课题组开展博士后研究，主要从事新型微蛋白的发现和功能表征。2020年9月加入中国药科大学药学院开始独立科研工作。迄今已经在Nat. Chem. Biol., Nat. Commun., JACS等国际重要科学期刊上发表论文多篇。热忱欢迎有志于化学生物学和药物化学的本科生和研究生加入课题组。
课题组研究方向：
新型多肽类生物探针及其生物医学应用
基于微蛋白生物功能的新靶点研究

联系方式：
qianchu927@yahoo.com
代表性论文：
1.Chu, Q., Martinez, T.F., Weiser Novak, S., Donaldson, C.J., Tan, D., Vaughan, J.M., Chang, T., Diedrich, J.K., Andrade, L., Kim, A., Zhang, T., Manor, U., Saghatelian, A., Regulation of the ER stress response by a mitochondrial microprotein. Nat. Commun., 2019, 10, 4883.
2. Martinez, T.F., Chu, Q., Donaldon, C.J., Tan, D., Shokhirev, M.N., Saghatelian, A., Accurate annotation of protein-coding small open reading frames in multiple human cell lines. Nat. Chem. Biol., 2020, 16, 458.
3. Chu, Q., Chang, T., Saghatelian, A., Substrate-Selective Enzyme Inhibitors. Trends Pharmacol. Sci., 2019, 40, 716.
4. Chu, Q., Saghatelian, A., A Hidden ORF Reveals an Immune Protector. Biochemistry, 2019, 58, 1022.
5.Chu, Q., Rathore, A., Diedrich, J.K., Donaldson, C.J., Yates, J.R., Saghatelian, A., Identification of microprotein-protein interactions via APEX tagging. Biochemistry, 2017, 56, 3299. (Editor’s choice, cover story)
6.Chu, Q., Diedrich, J.K., Vaughan, J.M., Donaldson, C.J., Nunn, M.F., Lee, K.F., Saghatelian, A., HtrA1 proteolysis of ApoE in vitro is allele selective, J. Am. Chem. Soc., 2016, 138, 9473.
7. Rathore, A., Chu, Q., Tan, D., Martinez, T.F., Donaldson, C.J., Diedrich, J.K., Yates, J.R., Saghatelian, A., MIEF1 Microprotein Regulates Mitochondrial Translation. Biochemistry, 2018, 57, 5564.
8. Nelson, A.T., Kolar, M.J., Chu, Q., Syed, I., Kahn, B.B., Saghatelian, A., Siegel, D., Stereochemistry of endogenous palmitic acid ester of 9-hydroxystearic acid and relevance of absolute configuration to regulation. J. Am. Chem. Soc., 2017, 139, 4943.
9. D’Lima, N.G., Ma, J., Winkler, L., Chu, Q., Loh, K.H., Corpuz, E.O., Budnik, B.A., Lykke-Anderson, J., Saghatelian, A., Slavoff, S.A., A human microprotein that interacts with the mRNA decapping complex. Nat. Chem. Biol., 2017, 13, 174.