相宏宇
姓名： 相宏宇

职称： 教授
最高学位： 博士
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工作地点： 吉林大学生命科学学院
研究方向： 研究方向：（1）资源微生物与生物转化；（2）蛋白质工程与健康。主要研究课题：①益生菌资源开发、机制研究与应用；②微生物转化中药新功能物质的发现及其性质研究；③肠道微生物组与免疫应答机制研究；④共存微生物发酵体系的开发及其应用；⑤蛋白质结构功能研究及靶向药物筛选与生物药创制。
教育经历： 1985.09-1989.07 山东大学微生物学系 微生物学专业 学士
2000.09-2003.03 日本筑波大学大学院生物系统研究科 生物系统学专业 硕士
2003.04-2006.03 日本筑波大学大学院生命环境科学研究科 生命共存科学专业 博士


工作经历： 1989.07-1993.03 白求恩医科大学 预防医学院 助教
1993.03-1995.07 美国独资 长春力达科技有限公司 科研部部长
1995.08-1996.07 长春远东化机有限公司 副总经理
1996.08-1999.08 长春天一生物工程有限公司 总工程师
2006.04-2010.08 日本 农业生物资源研究所 研究员
2010.09-2011.05 中国科学院微生物研究所 副研究员
2011.06-2015.09 吉林大学生命科学学院 副教授
2015.09- Present 吉林大学生命科学学院 教授

研究成果： 近5年发表SCI论文15篇，申请专利8件，其中2件已获得专利授权；先后主持省部级科研项目6项，其中2项通过省科技厅主持的项目鉴定；主讲本科生课程3门，研究生课程1门；培养硕士博士研究生14人。2015年作为主要发起人和申请人，申请"吉林省转化生物学与健康工程研究中心"，获得吉林省发改委批准立项。
1. Pan T, Xiang H, Diao T, Ma W, Shi C, Xu Y, Xie Q?. Effects of probiotics and nutrients addition on the microbial community and fermentation quality of peanut hull. Bioresour Technol. 2018 Nov 2; 273:144-152. doi: 10.1016/j.biortech.2018.10.088.
2. Wang Y, Xie Q, Sun S, Huang B, Zhang Y, Xu Y, Zhang S, Xiang H?. Probiotics-fermented Massa Medicata Fermentata ameliorates weaning stress in piglets related to improving intestinal homeostasis. Appl Microbiol Biotechnol. 2018 Nov 5. doi: 10.1007/s00253-018-9438-y.
3. Zhang Y, Xiang H, Sun L, Xie Q*, Liu M, Chen Y?, and Ruan S?. A Sensor Based on LiCl/NaA Zeolite Composites for Effective Humidity Sensing. Journal of Nanoscience and Nanotechnology. 2018, 18: 1882-1886.
4. Hu W, Xie Q, Liu L, Xiang H*. Enhanced Bioactivity of the Anti-LOX-1 scFv Engineered by Multimerization Strategy. Appl Biochem Biotechnol. 2017 Nov 9. doi: 10.1007/s12010-017-2649-3.
5. Hu W, Xie Q, Xiang H*. Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides. Biomed Res Int. 2017; 2017:**. doi: 10.1155/2017/**.
6. Gao X, Xie Q, Kong P, Liu L, Sun S, Xiong B, Huang B, Yan L, Sheng J, Xiang H*. Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice. Infect Immun. 2017 86(1) pii: e00601-17.
7. Gao X, Xie Q, Liu L, Kong P, Sheng J*, Xiang H*. Metabolic adaptation to the aqueous leaf extract of Moringa oleifera Lam.-supplemented diet is related to the modulation of gut microbiota in mice. Appl Microbiol Biotechnol., 2017 101(12): 5115-5130.
8. Hu W, Xiang JY, Kong P, Liu L, Xie Q, Xiang H*. Expression and characterization of a single-chain variable fragment against human LOX-1 in Escherichia coli and Brevibacillus choshinensis. J Microbiol Biotechnol., 2017 27(5): 965-974.
9. Meng Z, Xie Q, Liu Y, Zhang X, Xiang H*. Cellulase Production and Saccharification of Steam-exploded Corn Stover by Mutant Strain Trichoderma reesei EBUV-3. Int. J Agric. Biol., 2016 18(1): 213-17.
10. Chen C, Xiang JY, Hu W, Xie YB, Wang TJ, Cui JW, Xu Y, Liu Z, Xiang H*, Xie Q. Identification of key micro-organisms involved in Douchi fermentation by statistical analysis and their use in an experimental fermentation. J Applied Microbio., 2015 119(5): 1324-34.
11. Xin Q, Zhang H, Liu Q, Dong Z, Xiang H*, Gong JR*. Extracellular biocoordinated zinc nanofibers inhibit malignant characteristics of cancer cell. Nano Lett., 2015 15(10): 6490-3.
12. Liu Y, Meng Z, Shi R, Zhan L, Hu W, Xiang H*, Xie Q. Effects of temperature and additives on the thermal stability of glucoamylase from Aspergillus niger. J Microbiol Biotechnol. 2015 25(1):33-43.
13. Xu Y, Xie YB, Zhang XR, Chen C, Xiang H*, Xie Q*. Monitoring of the bacterial and fungal biodiversity and dynamics during Massa Medicata Fermentata fermentation. Appl Microbiol Biotechnol., 2013 97(22): 9647-55.
14. Mu T, Liang W, Ju Y, Wang Z, Wang Z, Roycik M, Sang QX, Yu D, Xiang H*, Fang X*. Efficient soluble expression of secreted Matrix Metalloproteinase 26 in Brevibacillus choshinensis. Protein Expr Purif., 2013 91(2): 125-33.
15. Liu Y, Li QS, Zhu HL, Meng ZL, Xiang H*, Xie Q. Purification and characterization of two thermostable glucoamylases produced by Aspergillus niger B-30. Chem. Res. Chinese Universities, 2013 29(5): 917-23.
16. Nishikiori M, Sugiyama S, Xiang H, Niiyama M, Ishibashi K, Inoue T, Ishikawa M, Matsumura H, Katoh E. Crystal structure of the superfamily 1 helicase from Tomato mosaic virus. J Virol. 2012 86(14): 7565-76.
17. Xiang H, Ishibashi K, Nishikiori M, Jaudal MC, Ishikawa M, Katoh E. Expression, purification, and functional characterization of a stable helicase domain from a tomato mosaic virus replication protein. Protein Expr Purif. 2012 81(1): 89-95.
18. Xiang H, Niiyama M, Sugiyama S, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Ishikawa M, Matsumura H, Katoh E. Crystallization and preliminary X-ray crystallographic analysis of a helicase-like domain from a tomato mosaic virus replication protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 67(Pt 12): 1649-52.
19. Okamura H, Nishikiori M, Xiang H, Ishikawa M, Katoh E. Interconversion of two GDP-bound conformations and their selection in an Arf-family small G protein. Structure. 2011 19(7): 988-98.
20. Xiang H, Takeuchi H, Tsunoda Y, Nakajima M, Murata K, Ueguchi-Tanaka M, Kidokoro S, Kezuka Y, Nonaka T, Matsuoka M, Katoh E. Thermodynamic characterization of OsGID1-gibberellin binding using calorimetry and docking simulations. J Mol Recognit. 2011 24(2): 275-82.
21. Shiba K, Niidome T, Katoh E, Xiang H, Han L, Mori T, Katayama Y. Polydispersity as a parameter for indicating the thermal stability of proteins by dynamic light scattering. Anal Sci. 2010; 26(6): 659-63.
22. Hirano K, Nakajima M, Asano K, Nishiyama T, Sakakibara H, Kojima M, Katoh E, Xiang H, Tanahashi T, Hasebe M, Banks JA, Ashikari M, Kitano H, Ueguchi-Tanaka M, Matsuoka M. The GID1-mediated gibberellin perception mechanism is conserved in the Lycophyte Selaginella moellendorffii but not in the Bryophyte Physcomitrella patens. Plant Cell. 2007 19(10): 3058-79.
23. Ueguchi-Tanaka M, Nakajima M, Katoh E, Ohmiya H, Asano K, Saji S, Xiang H, Ashikari M, Kitano H, Yamaguchi I, Matsuoka M. Molecular interactions of a soluble gibberellin receptor, GID1, with a rice DELLA protein, SLR1, and gibberellin. Plant Cell. 2007 19(7): 2140-55.
24. Xiang H, Masuo S, Hoshino T, Takaya N. Novel family of cholesterol esterases produced by actinomycetes bacteria. Biochim Biophys Acta. 2007 1774(1): 112-20.
25. Xiang H, Takaya N, Hoshino T. Novel cholesterol esterase secreted by Streptomyces persists during aqueous long-term storage. J Biosci Bioeng. 2006 101(1): 19-25.