顾景凯
姓名： 顾景凯

职称： 教授
最高学位： 博士
Email：
研究方向： 药代动力学研究、代谢组学研究、蛋白质组学研究等
工作经历： 现任吉林大学生命科学院唐敖庆特聘教授，药物代谢研究中心主任。
2003 年12 月吉林大学，被聘为博士生导师；
2001 年9 月 吉林大学，破格晋升为教授；
2000 年1 月 吉林大学，副教授；
1997 年至2000 年 吉林大学化学系，博士后；
1994 年至1997 年 沈阳药科大学，获药物分析博士学位。
研究成果： 近五年研究团队发表论文
1、Wang T, Ma W, Sun Y, Yang Y, Zhang W, Fawcett JP, Du H, Gu J. Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2013, 912:93-7.
2、Gai YY, Liu WH, Sha CJ, Wang YL, Sun YT, Li XJ, Paul Fawcett J, Gu JK. Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats J Ethnopharmacol. 2012, 143(1):249-255.
3、Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J. Paul Fawcett, Limei Zhao, Jiangkai Gu*. Determination of landiolol, an ultra-short-acting β1-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2012, 891-892, 7-11.
4、Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., and Ge, Y. (2012) Synergistic antitumor interactions between gemcitabine and clofarabine, Molecular medicine reports 5, 734-738.
5、Hong Cao, Yan Yang*. Biocatalytic synthesis of poly(δ-valerolactone) using a thermophilic esterase from Archaeoglobus fulgidus as catalyst. Int. J. Mol. Sci. 2012, 13: 12232-12241.
6、Yan Yang, Quanshun Li*. Cell-debris self-immobilized thermophilic esterase: a novel biocatalyst for synthesizing aliphatic polyesters. J. Control. Release (Abstract for SIPCD) 2012, in press.
7、Yan Yang*. A novel thermohilic histone with promising gene transfection efficiency. J. Control. Release (Abstract for SIPCD) 2012, in press.
8、Yang Yu, Yan Yang*. Lipase/esterase-catalyzed synthesis of aliphatic polyesters via polycondensation: a review. Process Biochem. 2012, 47: 1027-1036.
9、Wantong Song, Mingqiang Li, Zhaohui Tang, Quanshun Li, Yan Yang, Huaiyu Liu, Taicheng Duan, Hua Hong, Xuesi Chen*. Methoxy poly(ethylene glycol)-b-poly (L-glutamic acid) loaded cisplatin and a combination with iRGD for the treatment of non-small cell lung cancers. Macromol. Biosci. 2012, in press.
10、Zhang, M., Wu, X., Cui, X., Gao, F., Zhang, C., Yang, Y., and Gu, J. (2011) Simultaneous Determination of Escin Ia and Its Isomer Isoescin Ia by LC-MS-MS: Application to a Pharmacokinetic Study of Escin Ia in Rats, Chromatographia 74, 243-250.
11、Zhang, M., Gao, F., Cui, X., Zhang, Y., Sun, Y., and Gu, J. (2011) Development and Validation of an Improved Method for the Quantitation of Sertraline in Human Plasma using LC-MS-MS and Its Application to Bioequivalence Studies, Journal of Chromatographic Science 49, 89-93.
12、Zhang, D., Wang, Z., Zhao, X., Lu, W., Gu, J., and Cui, Y. (2011) Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Single Doses of Bivalirudin in Healthy Chinese Subjects, Biological & Pharmaceutical Bulletin 34, 1841-1848.
13、Zhang, C., Cui, X., Yang, Y., Gao, F., Sun, Y., Gu, J., Fawcett, J. P., Yang, W., and Wang, W. (2011) Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats, Xenobiotica 41, 340-348.
14、Yang, Y., Tsifansky, M. D., Shin, S., Lin, Q., and Yeo, Y. (2011) Mannitol-Guided Delivery of Ciprofloxacin in Artificial Cystic Fibrosis Mucus Model, Biotechnology and Bioengineering 108, 1441-1449.
15、Yan Yang, Quanshun Li*. Lipase/esterase-catalyzed ring-opening polymerization: a green polymer synthesis technique. Process Biochem. 2011, 46: 1900-1908.
16、Yan Yang, Quanshun Li*. Lipase-catalyzed synthesis of poly(ε-caprolactone) and its solid-state properties characterization. Biocatal. Biotransform. 2011, 16: 1201-1207.
17、Basma Ibrahim, Michael Tsifansky, Yan Yang, Yoon Yeo*. Challenges and advances in development of inhalable drug formulations for cystic fibrosis lung disease. Expert Opin. Drug Del. 2011, 8: 451-466.
18、Muharnmad, F., Guo, M., Qi, W., Sun, F., Wang, A., Guo, Y., and Zhu, G. (2011) pH-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles via Intracelluar Dissolution of ZnO Nanolids, Journal of the American Chemical Society 133, 8778-8781.
19、Muhammad, F., Guo, M., Guo, Y., Qi, W., Qu, F., Sun, F., Zhao, H., and Zhu, G. (2011) Acid degradable ZnO quantum dots as a platform for targeted delivery of an anticancer drug, Journal of Materials Chemistry 21, 13406-13412.
20、Meng, H., Ren, J., Lv, Y., Lin, W., and Guo, Y. (2011) Association study of CYP3A5 genetic polymorphism with serum concentrations of carbamazepine in Chinese epilepsy patients, Neurology Asia 16, 39-45.
21、Meng, H., Guo, G., Ren, J., Zhou, H., Ge, Y., and Guo, Y. (2011) Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy, Epilepsy & Behavior 21, 27-30.
22、Iliuk, A. B., Hu, L., and Tao, W. A. (2011) Aptamer in Bioanalytical Applications, Analytical Chemistry 83, 4440-4452.
23、Ibrahim, B. M., Tsifansky, M. D., Yang, Y., and Yeo, Y. (2011) Challenges and advances in the development of inhalable drug formulations for cystic fibrosis lung disease, Expert Opinion on Drug Delivery 8, 451-466.
24、Hu, L., and Tao, W. A. (2011) Chemical enrichment of tyrosine phosphopeptides, Se pu = Chinese journal of chromatography / Zhongguo hua xue hui 29, 869-875.
25、Hu, L., Iliuk, A., Galan, J., Hans, M., and Tao, W. A. (2011) Identification of Drug Targets In Vitro and in Living Cells by Soluble-Nanopolymer-Based Proteomics, Angewandte Chemie-International Edition 50, 4133-4136.
26、Cui, X., Zhang, M., Guan, X., Yin, L., Sun, Y., Fawcett, J. P., and Gu, J. (2011) LC-MS-MS Determination of Troxerutin in Plasma and Its Application to a Pharmacokinetic Study, Chromatographia 73, 165-169.
27、Zhang, C., Wang, L., Yang, Y., Sun, Y., Zhang, J., Li, G., and Gu, J. (2010) Validated LC-MS/MS method for the determination of sarpogrelate in human plasma: Application to a pharmacokinetic and bioequivalence study in Chinese volunteers, Journal of Pharmaceutical and Biomedical Analysis 53, 546-551.
28、Zhang, C., and Gu, J. (2010) Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats, Drug Metabolism Reviews 43, 73-74.
29、Yang, Y., Tsifansky, M. D., Wu, C.-J., Yang, H. I., Schmidt, G., and Yeo, Y. (2010) Inhalable Antibiotic Delivery Using a Dry Powder Co-delivering Recombinant Deoxyribonuclease and Ciprofloxacin for Treatment of Cystic Fibrosis, Pharmaceutical Research 27, 151-160.
30、Wu, X., Liu, L., Zhang, M., Wu, D., Wang, Y., Sun, Y., Fawcett, J. P., Gu, J., and Zhang, J. (2010) Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 878, 861-867.
31、Liu, L., Wu, X., Wu, D., Wang, Y., Li, P., Sun, Y., Yang, Y., Gu, J., and Cui, Y. (2010) A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration, Biomedical Chromatography 24, 1309-1315.
32、Li, H., Zhang, C., Wang, J., Jiang, Y., Fawcett, J. P., and Gu, J. (2010) Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 51, 716-722.
33、Hu, L., Ye, M., and Zou, H. (2010) Peptidome analysis of mouse liver tissue by size exclusion chromatography prefractionation, Methods in molecular biology (Clifton, N.J.) 615, 207-216.
34、Gao, F., Zhang, M., Cui, X., Wang, Z., Sun, Y., and Gu, J. (2010) Simultaneous quantitation of hydrochlorothiazide and metoprolol in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 52, 149-154.
35、Zhao, X., Liu, Y., Xu, J., Zhang, D., Zhou, Y., Gu, J., and Cui, Y. (2009) Determination of silodosin in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877, 3724-3728.
36、Zhang, D., Wang, Y., Han, J., Yu, W., Deng, L., Fawcett, J. P., Liu, Z., and Gu, J. (2009) Rapid and sensitive LC-MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877, 581-585.
37、Zhang, C., Wang, L., Yang, W., Wang, X., Fawcett, J. P., Sun, Y., and Gu, J. (2009) Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat, Journal of Pharmaceutical and Biomedical Analysis 50, 41-45.
38、Yu, W., Wang, Y., Zhang, Y., Lan, J., Liu, Z., Gu, J., Fawcett, J. P., and Zhang, D. (2009) Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877, 33-36.
39、Yang, Y., Bajaj, N., Xu, P., Ohn, K., Tsifansky, M. D., and Yeo, Y. (2009) Development of highly porous large PLGA microparticles for pulmonary drug delivery, Biomaterials 30, 1947-1953.
40、Wang, Y., Kong, L., Lei, X., Hu, L., Zou, H., Welbeck, E., Bligh, S. W. A., and Wang, Z. (2009) Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction, Journal of Chromatography A 1216, 2185-2191.
41、Tian, R., Ren, L., Ma, H., Li, X., Hu, L., Ye, M., Wu, R. a., Tian, Z., Liu, Z., and Zou, H. (2009) Selective enrichment of endogenous peptides by chemically modified porous nanoparticles for peptidome analysis, Journal of Chromatography A 1216, 1270-1278.
42、Sun, Y., Liu, M., Zhang, J., Jiang, Y., Yu, W., Fawcett, J. P., and Gu, J. (2009) Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 49, 1056-1059.
43、Si, D., Wang, Y., Zhou, Y.-H., Guo, Y., Wang, J., Zhou, H., Li, Z.-S., and Fawcett, J. P. (2009) Mechanism of CYP2C9 Inhibition by Flavones and Flavonols, Drug Metabolism and Disposition 37, 629-634.
44、Hu, L., Zhou, H., Li, Y., Sun, S., Guo, L., Ye, M., Tian, X., Gu, J., Yang, S., and Zou, H. (2009) Profiling of Endogenous Serum Phosphorylated Peptides by Titanium (IV) Immobilized Mesoporous Silica Particles Enrichment and MALDI-TOFMS Detection, Analytical Chemistry 81, 94-104.
45、Hu, L., Ye, M., and Zou, H. (2009) Recent advances in mass spectrometry-based peptidome analysis, Expert Review of Proteomics 6, 433-447.
46、Hu, L., Boos, K.-S., Ye, M., Wu, R. a., and Zou, H. (2009) Selective on-line serum peptide extraction and multidimensional separation by coupling a restricted-access material-based capillary trap column with nanoliquid chromatography-tandem mass spectrometry, Journal of Chromatography A 1216, 5377-5384.
47、Han, J., Jiang, S., Cui, X., Sun, Y., Li, G., Zhang, J., Fawcett, J. P., and Gu, J. (2009) Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 50, 171-174.
48、Chen, J., Gu, J., Zhao, R., Dai, R., and Wang, J. (2009) Simultaneous Nonchiral Determination of Artemisinin and Arteannuin B in Artemisia annua Using Circular Dichroism Detection, Chromatographia 69, 361-363.
49、Zhao, L., Li, H., Jiang, Y., Piao, R., Li, P., and Gu, J. (2008) Determination of ranolazine in human plasma by liquid chromatographic-tandem mass spectrometric assay, Journal of Chromatographic Science 46, 697-700.
50、Zhang, D., Du, X., Liu, M., Li, H., Jiang, Y., Zhao, L., and Gu, J. (2008) Determination of ecabet in human plasma by high-performance liquid chromatography-tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 863, 223-228.
51、Yang, Y., Li, H., Gao, K., Liu, M., Sun, Y., Yan, T., Fawcett, J. P., Cui, Y., and Gu, J. (2008) Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 862, 119-124.
52、Yan, T., Li, H., Deng, L., Guo, Y., Yu, W., Fawcett, J. P., Zhang, D., Cui, Y., and Gua, J. (2008) Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma, Journal of Pharmaceutical and Biomedical Analysis 48, 1225-1229.
53、Wu, R. a., Hu, L., Wang, F., Ye, M., and Zou, H. (2008) Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation, Journal of Chromatography A 1184, 369-392.
54、Wang, J., Jiang, Y., Wang, Y., Tang, Y., Teng, G., Fawcett, J. P., Kong, J., and Gu, J. (2008) A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies, Journal of Pharmaceutical and Biomedical Analysis 47, 985-989.
55、Wang, F., Ye, M., Dong, J., Tian, R., Hu, L., Han, G., Jiang, X., Wu, R. a., and Zou, H. (2008) Improvement of performance in label-free quantitative proteome analysis with monolithic electrospray ionization emitter, Journal of Separation Science 31, 2589-2597.
56、Gu, J., Liu, M., and Fawcett, J. P. (2008) PHARMACOKINETICS AND METABOLISM OF SOME POTENTIAL PRODRUGS OF O-DESMETHYLVENLAFAXINE, Drug Metabolism Reviews 40, 157-158.
57、Zhang, Y., Si, D., Chen, X., Lin, N., Guo, Y., Zhou, H., and Zhong, D. (2007) Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects, British Journal of Clinical Pharmacology 64, 67-74.
58、Zhang, X., Zhang, D., Xu, J., Gu, J., and Zhao, Y. (2007) Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 858, 65-70.
59、Wang, Y., Wang, Y., Li, P., Tang, Y., Fawcett, J. P., and Gu, J. (2007) Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 43, 1860-1863.
60、Wang, Y., Kong, L., Hu, L., Lei, X., Yang, L., Chou, G., Zou, H., Wang, C., Bligh, S. W. A., and Wang, Z. (2007) Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 860, 185-194.
61、Wang, J., Jiang, Y., Wang, Y., Zhao, X., Cui, Y., and Gu, J. (2007) Liquid chromatography tandem mass spectrometry assay to determine the pharmacokinetics of aildenafil in human plasma, Journal of Pharmaceutical and Biomedical Analysis 44, 231-235.
62、Wang, J., Jiang, Y., Wang, Y., Li, H., Fawcett, J. P., and Gu, J. (2007) Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high-performance liquid chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry 21, 1755-1758.
63、Tian, R., Zhang, H., Ye, M., Jiang, X., Hu, L., Li, X., Bao, X., and Zou, H. (2007) Selective extraction of peptides from human plasma by highly ordered mesoporous silica particles for peptidome analysis, Angewandte Chemie-International Edition 46, 962-965.
64、Tian, R., Ye, M., Hu, L., Li, X., and Zou, H. (2007) Selective extraction of peptides in acidic human plasma by porous silica nanoparticles for peptidome analysis with 2-D LC-MS/MS, Journal of Separation Science 30, 2204-2209.
65、Teng, G., Wang, Y., Tang, Y., Wang, R., Fang, Y., Fawcett, J. P., and Gu, J. (2007) Quantitation of iptakalim in human plasma by high-performance liquid chromatography-tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 859, 256-260.
66、Su, X., Kong, L., Lei, X., Hu, L., Ye, M., and Zou, H. (2007) Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods, Mini-Reviews in Medicinal Chemistry 7, 87-98.
67、Su, X., Hu, L., Kong, L., Lei, X., and Zou, H. (2007) Affinity chromatography with immobilized DNA stationary phase for biological fingerprinting analysis of traditional Chinese medicines, Journal of Chromatography A 1154, 132-137.
68、Liu, M., Zhang, D., Sun, Y., Wang, Y., Liu, Z., and Gu, J. (2007) Liquid chromatographic-electrospray tandem mass spectrometric determination of bisoprolol in human plasma, Biomedical Chromatography 21, 508-513.
69、Li, X., Wang, Y., Wang, J., Fawcett, J. P., Zhao, L., and Gu, J. (2007) Determination of miglitol chromatography/tandem in human plasma by liquid mass spectrometry, Rapid Communications in Mass Spectrometry 21, 247-251.
70、Li, H., Wang, Y., Jiang, Y., Tang, Y., Wang, J., Zhao, L., and Gu, J. (2007) A liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of valsartan and hydrochlorothiazide in human plasma, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 852, 436-442.
71、Jiang, Y., Wang, J., Wang, Y., Li, H., Fawcett, J. P., and Gu, J. (2007) Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of colchicine in human plasma, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 850, 564-568.
72、Jiang, Y., Wang, J., Wang, Y., Du, X., Zhang, Y., Fawcett, J. P., and Gu, J. (2007) Determination of long-acting release octreotide, an octapeptide analogue of in human plasma by liquid somatostation, chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry 21, 3982-3986.
73、Jiang, Y., Wang, J., Li, H., Wang, Y., and Gu, J. (2007) Determination of clarithromycin in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 43, 1460-1464.
74、Hu, L., Ye, M., Jiang, X., Feng, S., and Zou, H. (2007) Advances in hyphenated analytical techniques for shotgun proteome and peptidome analysis - A review, Analytica Chimica Acta 598, 193-204.
75、Hu, L., Li, X., Jiang, X., Zhou, H., Jiang, X., Kong, L., Ye, M., and Zou, H. (2007) Comprehensive peptidome analysis of mouse livers by size exclusion chromatography prefractionation and NanoLC-MS/MS identification, Journal of Proteome Research 6, 801-808.