王冠
姓名： 王冠

职称： 副教授
最高学位： 博士
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工作地点： 生科楼320
研究方向： 1，以HDAC和WEE1为靶点治疗急性髓系白血病的研究2，急性髓系白血病和胰腺癌的转化医学研究
教育经历： 2004.9-2008.6，吉林大学，生命科学院，生物技术，本科
2008.9-2014.6，吉林大学，生命科学院，生物化学与分子生物学，博士
2012.2-2014.2，美国韦恩州立大学，Karmanos癌症研究所，交流学习

工作经历： 2014.7-至今，吉林大学，生命科学院，生物化学与分子生物学，讲师
研究成果： 1.Shuang Liu, Yubin Ge, Tingting Wang, Holly Edwards, Qihang Ren, Yiqun Jiang, Chengshi Quan#, Guan Wang#, Inhibition of ATR Potentiates the Cytotoxic Effect of Gemcitabine on Pancreatic Cancer Cells through Enhancement of DNA Damage and Abrogation of Ribonucleotide Reductase Induction by Gemcitabine, Oncology Reports, 2017, 37(6):3377-3386
2.Haijiao Zheng, Tenggao Zhu, Xiqian Li, Guan Wang#, Qiong Jia#, Immobilization of beta-Cyclodextrin-Conjugated Lactoferrin onto Polymer Monolith for Enrichment of Ga in Metabolic Residues of Ga-Based Anticancer Drugs, Biomacromolecules, 2017, 18: 3971-3977
3.Xiaojia Niu, Jianyun Zhao, Jun Ma, Chengzhi Xie, Holly Edwards, Guan Wang, J. Timothy Caldwell, Shenyan Xiang, Xiaohong Zhang, Roland Chu, Zhihong Wang, Hai Lin*, Jeffrey W. Taub*, Yubin Ge*, Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells, Clinical Cancer Research, 2016, 22(17): 4440-4451
4.Guan Wang#, Xiaojia Niu#, Wenbo Zhang, J. Timothy Caldwell, Holly Edwards, Wei Chen, Jeffrey W. Taub, Lijing Zhao*, Yubin Ge*, Synergistic Antitumor Interactions Between MK-1775 and Panobinostat in Preclinical Models of Pancreatic Cancer, Cancer Letters, 2015, 356(2 Pt B):656-668
5.Santosh S. Hanmod#, Guan Wang#, Holly Edwards, Steven A. Buck, Yubin Ge*, Jeffrey W. Taub*, Zhihong Wang*, Targeting Histone Deacetylases (HDACs) and Wee1 for Treating High-Risk Neuroblastoma, Pediatr Blood Cancer, 2015, 62(1):52-59
6.Chengzhi Xie#, Holly Edwards#, J. Timothy Caldwell, Guan Wang, Jeffrey W. Taub, Yubin Ge*, Obatoclax Potentiates the Cytotoxic Effect of Cytarabine on Acute Myeloid Leukemia Cells by Enhancing DNA Damage, Molecular Oncology, 2015, 9(2): 409-421
7.Guan Wang, Shaohua Chen, Holly Edwards, Xinming Cui, Li Cui, Yubin Ge*, Combination of Chloroquine and GX15-070 (Obatoclax) Results in Synergistic Cytotoxicity against Pancreatic Cancer Cells, Oncology Reports, 2014, 32(6):2789-2794
8.Xiaojia Niu#, Guan Wang#, Yue Wang, J. Timothy Caldwell, Holly Edwards, Chengzhi Xie, Jeffrey W. Taub, Chunhuai Li, Hai Lin, Yubin Ge*, Acute Myeloid Leukemia Cells Harboring MLL Fusion Genes or with the Acute Promyelocytic Leukemia Phenotype are Sensitive to the Bcl-2-Selective Inhibitor ABT-199, Leukemia, 2014, 28(7): 1557-1560
9.Shaohua Chen, Guan Wang, Xiaojia Niu, Jianyun Zhao, Wenxi Tan, Hebin Wang, Lijing Zhao*, Yubin Ge*, Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) Results in Synergistic Antitumor Activities in Preclinical Models of Pancreatic Cancer, Cancer Letters, 2014, 348(1-2):20-8
10.Guan Wang, Jing He, Jianyun Zhao, Wenting Yun, Chengzhi Xie, Jeffrey W. Taub, Asfar Azmi, Ramzi M. Mohammad, Yan Dong, Wei Kong, Yingjie Guo*, Yubin Ge*, Class I and Class II Histone Deacetylases are Potential Therapeutic Targets for Treating Pancreatic Cancer, PLoS One, 2012, 7(12): e52095