谢秋宏
姓名： 谢秋宏

职称： 教授
最高学位： 博士
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工作地点： 吉林大学生命科学学院
研究方向： 研究方向：（1）资源微生物与生物转化；（2）蛋白质工程与健康。主要研究课题：①益生菌资源开发、机制研究与应用；②微生物转化中药新功能物质的发现及其性质研究；③肠道微生物组与免疫应答机制研究；④共存微生物发酵体系的开发及其应用；⑤蛋白质结构功能研究及靶向药物筛选与生物药创制。
教育经历： 1995.09-1998.02 中国科学院 沈阳应用生态研究所 微生物学专业 博士
1989.09-1992.07 吉林大学 分子生物学系 生物化学与分子生物学专业 硕士
1985.09-1989.07 山东大学 微生物学系 微生物学专业 学士


工作经历： 2008.04-今 吉林大学生命科学学院 教授
2004.10-2008.03 日本动物卫生研究所 研究员
2001.10-2004.09 日本食品综合研究所 研究员
2001.04-2001.09 日本国际科学振兴财团生物研究所 研究员
1999.04-2001.03 日本工业技术院生命工学工业技术研究所 研究员
1998.04-1999.03 日本关西学院大学理学部 研究员
1998.09-1999.03 吉林大学生命科学学院 副教授
1994.07-1998.08 吉林大学生命科学学院 讲 师
1992.07-1994.06 吉林大学生命科学学院 助 手


研究成果： 近5年发表SCI论文13篇，申请专利8件，其中2件已获得专利授权；先后主持省部级科研项目8项，其中1项通过省科技厅主持的项目鉴定；主讲本科生课程3门，研究生课程1门；培养硕士博士研究生20人。2015年作为主要发起人和申请人，申请"吉林省转化生物学与健康工程研究中心"，获得吉林省发改委批准立项。
1. Pan T, Xiang H, Diao T, Ma W, Shi C, Xu Y, Xie Q. Effects of probiotics and nutrients addition on the microbial community and fermentation quality of peanut hull. Bioresour Technol. 2018 Nov 2; 273:144-152. doi: 10.1016/j.biortech.2018.10.088.
2. Wang Y, Xie Q, Sun S, Huang B, Zhang Y, Xu Y, Zhang S, Xiang H. Probiotics-fermented Massa Medicata Fermentata ameliorates weaning stress in piglets related to improving intestinal homeostasis. Appl Microbiol Biotechnol. 2018 Nov 5. doi: 10.1007/s00253-018-9438-y.
3. Zhang Y, Xiang H, Sun L, Xie Q, Liu M, Chen Y, Ruan S. A Sensor Based on LiCl/NaA Zeolite Composites for Effective Humidity Sensing. Journal of Nanoscience and Nanotechnology. 2018, 18: 1882-1886.
4. Hu W, Xie Q, Liu L, Xiang H. Enhanced Bioactivity of the Anti-LOX-1 scFv Engineered by Multimerization Strategy. Appl Biochem Biotechnol. 2017 Nov 9. doi: 10.1007/s12010-017-2649-3.
5. Hu W, Xie Q, Xiang H. Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides. Biomed Res Int. 2017; 2017:**. doi: 10.1155/2017/**.
6. Gao X, Xie Q, Kong P, Liu L, Sun S, Xiong B, Huang B, Yan L, Sheng J, Xiang H. Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice. Infect Immun. 2017 86(1) pii: e00601-17.
7. Gao X, Xie Q, Liu L, Kong P, Sheng J, Xiang H. Metabolic adaptation to the aqueous leaf extract of Moringa oleifera Lam.-supplemented diet is related to the modulation of gut microbiota in mice. Appl Microbiol Biotechnol., 2017 101(12): 5115-5130.
8. Hu W, Xiang JY, Kong P, Liu L, Xie Q, Xiang H. Expression and characterization of a single-chain variable fragment against human LOX-1 in Escherichia coli and Brevibacillus choshinensis. J Microbiol Biotechnol., 2017 27(5): 965-974.
9. Meng Z, Xie Q, Liu Y, Zhang X, Xiang H. Cellulase Production and Saccharification of Steam-exploded Corn Stover by Mutant Strain Trichoderma reesei EBUV-3. Int. J Agric. Biol., 2016 18(1): 213-17.
10. Chen C, Xiang JY, Hu W, Xie YB, Wang TJ, Cui JW, Xu Y, Liu Z, Xiang H, Xie Q. Identification of key micro-organisms involved in Douchi fermentation by statistical analysis and their use in an experimental fermentation. J Applied Microbio., 2015 119(5): 1324-34.
11. Liu Y, Meng Z, Shi R, Zhan L, Hu W, Xiang H, Xie Q. Effects of temperature and additives on the thermal stability of glucoamylase from Aspergillus niger. J Microbiol Biotechnol. 2015 25(1):33-43.
12. Xu Y, Xie YB, Zhang XR, Chen C, Xiang H, Xie Q. Monitoring of the bacterial and fungal biodiversity and dynamics during Massa Medicata Fermentata fermentation. Appl Microbiol Biotechnol., 2013 97(22): 9647-55.
13. Liu Y, Li QS, Zhu HL, Meng ZL, Xiang H, Xie Q. Purification and characterization of two thermostable glucoamylases produced by Aspergillus niger B-30. Chem. Res. Chinese Universities, 2013 29(5): 917-23.
14.Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S. Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Biochem Biophys Res Commun. 2013 May 10; 434(3):594-9.
15. Kumano-Kuramochi M, Shimozu Y, Wakita C, Ohnishi-Kameyama M, Shibata T, Matsunaga S, Takano-Ishikawa Y, Watanabe J, Goto M, Xie Q, Komba S, Uchida K, Machida S. Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Biochem J. 2012 Feb 15; 442(1):171-80.
16. Matsunaga S, Xie Q, Kumano-Kuramochi M, Komba S, Machida S. Silicone-urethane adhesive for improved coverslip mounting and leak-free preparation of living cell observation chambers. Biotechniques. 2009 Mar; 46(3):225-7.
17. Kumano-Kuramochi M, Xie Q, Sakakibara Y, Niimi S, Sekizawa K, Komba S, Machida S. Expression and characterization of recombinant C-terminal biotinylated extracellular domain of human receptor for advanced glycation end products (hsRAGE) in Escherichia coli. J Biochem. 2008 Feb; 143(2):229-36.
18. Matsunaga S, Xie Q, Kumano M, Niimi S, Sekizawa K, Sakakibara Y, Komba S, Machida S. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) functions as an oligomer and oligomerization is dependent on receptor density. Exp Cell Res. 2007 Apr 1; 313(6):1203-14.
19. Takahashi H1, Arai M, Takenawa T, Sota H, Xie QH, Iwakura M. Stabilization of hyperactive dihydrofolate reductase by cyanocysteine-mediated backbone cyclization. J Biol Chem. 2007 Mar 30; 282(13):9420-9. Epub 2007 Jan 30.
20. Xie Q, Matsunaga S, Wen Z, Niimi S, Kumano M, Sakakibara Y, Machida S. In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes. J Pept Sci. 2006 Oct; 12(10):643-52.
21. Ohki I, Ishigaki T, Oyama T, Matsunaga S, Xie Q, Ohnishi-Kameyama M, Murata T, Tsuchiya D, Machida S, Morikawa K, Tate S. Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure. 2005 Jun; 13(6):905-17.
22. Xie Q, Matsunaga S, Niimi S, Ogawa S, Tokuyasu K, Sakakibara Y, Machida S. Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells. DNA Cell Biol. 2004 Feb; 23(2):111-7.
23. Xie Q, Matsunaga S, Shi X, Ogawa S, Niimi S, Wen Z, Tokuyasu K, Machida S. Refolding and characterization of the functional ligand-binding domain of human lectin-like oxidized LDL receptor. Protein Expr Purif. 2003 Nov; 32(1):68-74.