Ting XIE
解亭
PhD in Molecular Biology and Biochemistry
Rutgers University, and the University of Medicine and Dentistry of New Jersey, 1996

Head and Chair Professor
Division of Life Science

Kerry Holdings Professor of Science

Director of Biomedical Research Institute, HKUST-Peking University Shenzhen Medical Center



(852) 3469 2792
tgx@ust.hk
Room 5467
Personal Web

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Scopus ID
7103076407




Research Interest Publications Projects Teaching Assignment RPG Supervision




Research Interest

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Stem cell biology



Publications

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All Years 73 2022 0 2021 1 2020 3 2019 3 2018 1 2017 3 2016 62

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2021 1

NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression
Cell Reports, v. 34, (2), January 2021, article number 108603
Pang, Ji; Le, Liang; Zhou, Yi; Tu, Renjun; Hou, Qiang; Tsuchiya, Dai; Thomas, Nancy; Wang, Yongfu; Yu, Zulin; Alexander, Richard; Thexton, Marina; Lewis, Brandy; Corbin, Timothy; Durnin, Michael; Li, Hua; Ashery-Padan, Ruth; Yan, Deyue; Xie, Ting Article

2020 3

Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation
Science Advances, v. 6, (20), May 2020, article number eaaz0480
Tu, Renjun; Duan, Bo; Song, Xiaoqing; Xie, Ting Article
Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs
Proceedings of the National Academy of Sciences of the United States of America, v. 117, (7), February 2020, p. 3603-3609
Zou, Fan; Tu, Renjun; Duan, Bo; Yang, Zhenlin; Ping, Zhaohua; Song, Xiaoqing; Chen, Shiyuan; Price, Andrew; Li, Hua; Scott, Allison; Perera, Anoja; Li, Sisi; Xie, Ting Article
Multiple niche compartments orchestrate stepwise germline stem cell progeny differentiation
Current Biology, v. 31, (4), 22 February 2021, p. 827-839.e3
Tu, Renjun; Duan, Bo; Song, Xiaoqing; Chen, Shiyuan; Scott, Allison; Hall, Kate; Blanck, Jillian; DeGraffenried, Dustin; Li, Hua; Perera, Anoja; Haug, Jeff; Xie, Ting Article

2019 3

Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen
Journal of Genetics and Genomics, v. 46, (1), January 2019, p. 19-30
Gao, Yuan; Mao, Ying; Xu, Rong-Gang; Zhu, Ruibao; Zhang, Ming; Sun, Jin; Shen, Da; Peng, Ping; Xie, Ting; Ni, Jian-Quan Article
Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells
Life Science Alliance, v. 2, (5), October 2019, article number e201800211
Story, Benjamin; Ma, Xing; Ishihara, Kazue; Li, Hua; Hall, Kathryn; Peak, Allison; Anoja, Perera; Park, Jungun; Haug, Jeff; Blanchette, Marco; Xie, Ting Article
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
Development, v. 146, (13), 28 June 2019, article number UNSP dev174615
Mao, Ying; Tu, Renjun; Huang, Yan; Mao, Decai; Yang, Zhihao; Lau, Pik Ki; Wang, Jinhui; Ni, Jianquan; Guo, Yusong; Xie, Ting Article

2018 1

Regional gene expression profile comparison reveals the unique transcriptome of the optic fissure
Investigative Ophthalmology and Visual Science, v. 59, (15), December 2018, p. 5773-5784
Cao, Mingzhe; Ouyang, Jiamin; Liang, Huilin; Guo, Jingyi; Lin, Siyuan; Yang, Shulan; Xie, Ting; Chen, Shuyi Article

2017 3

Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms
Developmental Cell, v. 41, (2), April 2017, p. 157-169.e5
Ma, Xing; Zhu, Xiujuan; Han, Yingying; Story, Benjamin; Do, Trieu; Song, Xiaoqing; Wang, Su; Zhang, Ying; Blanchette, Marco; Gogol, Madelaine; Hall, Kate; Peak, Allison; Anoja, Perera; Xie, Ting Article
Recapitulating and correcting marfan syndrome in a cellular model
International Journal of Biological Sciences, v. 13, (5), 2017, p. 588-603
Park, Jung Woo; Yan, Li; Stoddard, Chris; Wang, Xiaofang; Yue, Zhenwu; Crandall, Leann; Robinson, Tiwanna; Chang, Yuxiao; Denton, Kyle; Li, Enqin; Jiang, Bin; Zhang, Zhenwu; Martins-Taylor, Kristen; Yee, Siu-Pok; Nie, Hong; Gu, Feng; Si, Wei; Xie, Ting; Yue, Lixia; Xu, Ren-He Article
Trio-based exome sequencing arrests de novo mutations in early-onset high myopia
Proceedings of the National Academy of Sciences of the United States of America, v. 114, (16), April 2017, p. 4219-4224
Jin, Zi-Bing; Wu, Jinyu; Xie, Ting Article

2016 2

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Development (Cambridge), v. 143, (23), December 2016, p. 4312-4323
Ma, Xing; Han, Yingying; Song, Xiaoqing; Do, Trieu; Yang, Zhihao; Ni, Jianquan; Xie, Ting Article
Ocular stem cell research from basic science to clinical application: A report from zhongshan ophthalmic center ocular stem cell symposium
International Journal of Molecular Sciences, v. 17, (3), March 2016, article number 415
Ouyang, Hong; Goldberg, Jeffery L.; Chen, Shuyi; Li, Wei; Xu, Guo-Tong; Zhang, Kang; Nussenblatt, Robert B.; Liu, Yizhi; Xie, Ting; Chan, Chi-Chao; Zack, Donald J. Article

2015 6

COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary
Development (Cambridge), v. 142, (24), December 2015, p. 4242-4252
Lu, Tinglin; Wang, Su; Gao, Yuan; Mao, Ying; Yang, Zhihao; Liu, Luping; Song, Xiaoqing; Ni, Jianquan; Xie, Ting Article
Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state
Journal of Biological Chemistry, v. 290, (37), September 2015, p. 22782-22794
Ouyang, Juan; Yu, Wei; Liu, Jing; Zhang, Nian; Florens, Laurence; Chen, Jiekai; Liu, He; Washburn, Michael; Pei, Duanqing; Xie, Ting Article
Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation
Nature Communications, v. 6, November 2015, article number 8856
Sun, Jin; Wei, Hui-Min; Xu, Jiang; Chang, Jian-Feng; Yang, Zhihao; Ren, Xingjie; Lv, Wen-Wen; Liu, Lu-Ping; Pan, Li-Xia; Wang, Xia; Qiao, Huan-Huan; Zhu, Bing; Ji, Jun-Yuan; Yan, Dong; Xie, Ting; Sun, Fang-Lin; Ni, Jian-Quan Article
Responses of Multipotent Retinal Stem Cells to IL-1 β, IL-18, or IL-17
Journal of Ophthalmology, v. 2015, 2015, article number 369312
Chen, Shida; Shen, Defen; Popp, Nicholas A.; Ogilvy, Alexander J.; Tuo, Jingsheng; Abu-Asab, Mones; Xie, Ting; Chan, Chi-Chao Article
Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways
Cell Reports, v. 13, (7), November 2015, p. 1366-1379
Fu, Ziwen; Geng, Cuiyun; Wang, Hui; Yang, Zhihao; Weng, Changjiang; Li, Hua; Deng, Lamei; Liu, Luping; Liu, Nan; Ni, Jianquang; Xie, Ting Article
Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche
eLife, v. 4, October 2015, article number e08174
Wang, Su; Gao, Yuan; Song, Xiaoqing; Ma, Xing; Zhu, Xiujuan; Mao, Ying; Yang, Zhihao; Ni, Jianquan; Li, Hua; Malanowski, Kathryn E.; Anoj, Perera; Park, Jungeun; Haug, Jeff; Xie, Ting Article

2014 4

A regulatory network of Drosophila germline stem cell self-renewal
Developmental Cell, v. 28, (4), February 2014, p. 459-473
Yan, Dong; Neumüller, Ralph A.; Buckner, Michael; Ayers, Kathleen; Li, Hua; Hu, Yanhui; Yang-Zhou, Donghui; Pan, Lei; Wang, Xiaoxi; Kelley, Colleen; Vinayagam, Arunachalam; Binari, Richard; Randklev, Sakara; Perkins, Lizabeth A.; Xie, Ting; Cooley, Lynn; Perrimon, Norbert Article
Extracellular, stem cells and regenerative ophthalmology
Journal of Glaucoma, v. 23, (8), December 2014, p. S30-S33
Wang, Yifeng; Xie, Ting Article
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary
PLoS ONE, v. 9, (3), March 2014, article number e90267
Ma, Xing; Wang, Su; Do, Trieu; Song, Xioaqing; Inaba, Mayu; Nishimoto, Yoshiya; Liu, Lu-Ping; Gao, Yuan; Mao, Ying; Li, Hui; McDowell, William; Park, Jungeun; Malanowski, Kate; Peak, Allison; Perera, Anoja; Li, Hua; Gaudenz, Karin; Haug, Jeff; Yamashita, Yukiko; Lin, Haifan; Ni, Jian-Quan; Xie, Ting Article
Protein competition switches the function of COP9 from self-renewal to differentiation
Nature, v. 514, (7521), October 2014, p. 233-236
Pan, Lei; Wang, Su; Lu, Tinglin; Weng, Changjiang; Song, Xiaoqing; Park, Joseph K.; Sun, Jin; Yang, Zhi-Hao; Yu, Junjing; Tang, Hong; McKearin, Dennis M.; Chamovitz, Daniel A.; Ni, Jianquan; Xie, Ting Article

2013 7

Adhesion in the stem cell niche: Biological roles and regulation
Development (Cambridge), v. 140, (2), January 2013, p. 255-265
Chen, Shuyi; Lewallen, Michelle; Xie, Ting Article
Cell-based therapies for retinal degenerative diseases: A thousand strategies
Journal of Glaucoma, v. 22, (5 SUPPL.1), June 2013, p. S42-S45
Lewallen, Michelle; Xie, Ting Article
Control of germline stem cell self-renewal and differentiation in the Drosophila ovary: concerted actions of niche signals and intrinsic factors
Wiley Interdisciplinary Review-Developmental Biology, v. 2, (2), Mar-Apr 2013, p. 261-273
Xie, Ting Article
Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis
Cell Research, v. 23, (2), February 2013, p. 254-273
Chen, Shuyi; Li, Hua; Gaudenz, Karin; Paulson, Ariel; Guo, Fengli; Trimble, Rhonda; Peak, Allison; Seidel, Christopher; Deng, Chuxia; Furuta, Yasuhide; Xie, Ting Article
Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells
Cell Research, v. 23, (6), June 2013, p. 788-802
Li, Tianqing; Lewallen, Michelle; Chen, Shuyi; Yu, Wei; Zhang, Nian; Xie, Ting Article
Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (22), May 2013, p. 8966-8971
Zhou, Yi; Tanzie, Christopher; Yan, Zhipeng; Chen, Shuyi; Duncan, Michael; Gaudenz, Karin; Li, Hua; Seidel, Christopher; Lewis, Brandy; Moran, Andrea; Libby, Richard T.; Kiernan, Amy E.; Xie, Ting Article
Stem Cells' Exodus: A Journey to Immortality
Developmental Cell, v. 24, (2), January 2013, p. 113-114
Zhou, Yi; Lewallen, Michelle; Xie, Ting Article

2012 2

Cadherin-Mediated Cell Adhesion Is Critical for the Closing of the Mouse Optic Fissure
PLoS ONE, v. 7, (12), December 2012, article number e51705
Chen, Shuyi; Lewis, Brandy; Moran, Andrea; Xie, Ting Article
Mathematical Model for Two Germline Stem Cells Competing for Niche Occupancy
Bulletin of Mathematical Biology, v. 74, (5), May 2012, p. 1207-1225
Tian, Jianjun P.; Jin, Zhigang; Xie, Ting Article

2011 5

A PGC-1 tale: Healthier intestinal stem cells, longer life
Cell Metabolism, v. 14, (5), November 2011, p. 571-572
Zhou, Yi; Lu, Tu; Xie, Ting Article
Histone H3K9 trimethylase eggless controls germline stem cell maintenance and differentiation
PLoS Genetics, v. 7, (12), December 2011, article number e1002426
Wang, Xiaoxi; Pan, Lei; Wang, Su; Zhou, Jian; McDowell, William; Park, Jungeun; Haug, Jeff; Staehling, Karen; Tang, Hong; Xie, Ting Article
Restricting self-renewal signals within the stem cell niche: Multiple levels of control
Current Opinion in Genetics and Development, v. 21, (6), December 2011, p. 684-689
Chen, Shuyi; Wang, Su; Xie, Ting Article
Self-maintained escort cells form a germline stem cell differentiation niche
Development, v. 138, (23), December 2011, p. 5087-5097
Kirilly, Daniel; Wang, Su; Xie, Ting Article
Stem cells: Keeping BMP signaling local
Current Biology, v. 21, (19), October 2011, p. R809-R811
Ma, Xing; Xie, Ting Article

2010 1

Lissencephaly-1 controls germline stem cell self- renewal through modulating bone morphogenetic protein signaling and niche adhesion
Journal of Molecular Cell Biology, v. 107, (46), November 2010, p. 19939-19944
Chen, Shuyi; Kaneko, Satoshi; Ma, Xing; Chen, Xiaochu; Ip, Y. Tony; Xu, Lan; Xie, Ting Article

2009 2

eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary
Proceedings of the National Academy of Sciences of the United States of America, v. 106, (28), July 2009, p. 11623-11628
Shen, Run; Weng, Changjiang; Yu, Junjing; Xie, Ting Article
Stem Cell in the Adult Drosophila Hindgut: Just a Sleeping Beauty
Cell Stem Cell, v. 5, (3), September 2009, p. 227-228
Xie, Ting Article

2008 6

Differentiation-Defective Stem Cells Outcompete Normal Stem Cells for Niche Occupancy in the Drosophila Ovary
Cell Stem Cell, v. 2, (1), January 2008, p. 39-49
Jin, Zhigang; Kirilly, Daniel; Weng, Changjiang; Kawase, Eihachiro; Song, Xiaoqing; Smith, Sarah; Schwartz, Joel; Xie, Ting Article
Germline Stem Cell Niches
StemBook, 30 September 2008, article number 497
Xie, Ting Article
Physiology: Burn fat, live longer
Science, v. 322, (5903), November 2008, p. 865-866
Xie, Ting Article
Stem cell self-renewal versus differentiation: Tumor suppressor Mei-P26 and miRNAs control the balance
Cell Research, v. 18, (7), July 2008, p. 713-715
Shen, Run; Xie, Ting Article
Extrinsic and intrinsic control of germline stem cell regulation in the Drosophila ovary
Regulatory Networks in Stem Cells / Vinagolu K. Rajasekhar, Mohan C. Vemuri (eds.). New York, NY : Humana Press, 2009, p. 155-164, Book series: Stem Cell Biology and Regenerative Medicine
Zhang, Ning; Xie, Ting Book chapter
Interactions between stem cells and their niche in the Drosophila ovary
Cold Spring Harbor Symposia on Quantitative Biology, v. 73, 2008, p. 39-47
Xie, Ting; Song, X.; Jin, Z.; Pan, L.; Weng, C.; Chen, S.; Zhang, N. Conference paper

2007 5

Dcr-1 Maintains Drosophila Ovarian Stem Cells
Current Biology, v. 17, (6), March 2007, p. 539-544
Jin, Zhigang; Xie, Ting Article
Notch signaling controls germline stem cell niche formation in the Drosophila ovary
Development, v. 134, (6), March 2007, p. 1071-1080
Song, Xiaoqing; Call, Gerald B.; Kirilly, Daniel; Xie, Ting Article
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Cell Stem Cell, v. 1, (4), October 2007, p. 458-469
Pan, Lei; Chen, Shuyi; Weng, Changjiang; Call, Gerald; Zhu, Dongxiao; Tang, Hong; Zhang, Nian; Xie, Ting Article
Stem cells and their niche: An inseparable relationship
Development, v. 134, (11), June 2007, p. 2001-2006
Xie, Ting; Li, Linheng Article
The Drosophila ovary: An active stem cell community
Cell Research, v. 17, (1), January 2007, p. 15-25
Kirilly, Daniel; Xie, Ting Article

2006 1

Germline Specification: Small Things Have a Big Role
Current Biology, v. 16, (22), November 2006, p. R966-R967
Jin, Zhigang; Xie, Ting Article

2005 7

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary
Developmental Cell, v. 9, (5), November 2005, p. 651-662
Kirilly, Daniel; Spana, Eric P.; Perrimon, Norbert; Padgett, Richard W.; Xie, Ting Article
Intimate relationships with their neighbors: Tales of stem cells in Drosophila reproductive systems
Developmental Dynamics, v. 232, (3), March 2005, p. 775-790
Xie, Ting; Kawase, Eihachiro; Kirilly, Daniel; Wong, Marco D. Article
Molecular mechanisms controlling germline and somatic stem cells: Similarities and differences
Current Opinion in Genetics and Development, v. 15, (4), August 2005, p. 381-387
Xi, Rongwen; Kirilly, Daniel; Xie, Ting Article
Molecular mechanisms of germline stem cell regulation
Annual Review of Genetics, v. 39, December 2005, p. 173-195
Wong, Marco D.; Jin, Zhigang; Xie, Ting Article
Pelota controls self-renewal of germline stem cells by repsessing a Bam-independent differentiation pathway
Development, v. 132, (24), 2005, p. 5365-5374
Xi, Rongwen; Doan, Choung; Liu, Dazhi; Xie, Ting Article
Stem cell niche: Structure and function
Annual Review of Cell and Developmental Biology, v. 21, November 2005, p. 605-631
Li, Linheng; Xie, Ting Article
Stem cell self-renewal controlled by chromatin remodeling factors
Science, v. 310, (5753), December 2005, p. 1487-1489
Xi, Rongwen; Xie, Ting Article

2004 2

Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
Development, v. 131, (6), March 2004, p. 1353-1364
Song, Xiaoqing; Wong, Marco D.; Kawase, Eihachiro; Xi, Rongwen; Ding, Bee C.; McCarthy, John J.; Xie, Ting Article
Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
Development, v. 131, (6), March 2004, p. 1365-1375
Kawase, Eihachiro; Wong, Marco D.; Ding, Bee C.; Xie, Ting Article

2003 2

Clonal expansion of ovarian germline stem cells during niche formation in Drosophila
Development, v. 130, (12), June 2003, p. 2579-2588
Zhu, Chun-Hong; Xie, Ting Article
Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila
Development, v. 130, (14), July 2003, p. 3259-3268
Song, Xiaoqing; Xie, Ting Article

2002 2

DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary
Proceedings of the National Academy of Sciences of the United States of America, v. 99, (23), November 2002, p. 14813-14818
Song, Xiaoqing; Xie, Ting Article
Germline stem cells anchored by adherens junctions in the Drosophila ovary niches
Science, v. 296, (5574), June 2002, p. 1855-1857
Song, Xiaoqing; Zhu, Chun-Hong; Doan, Chuong; Xie, Ting Article

2001 1

The Drosophila ovary: An in vivo stem cell system
Stem Cell Biology / Edited by Daniel R. Marshak, Richard L. Gardner,David Gottlieb. Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, 2001, p. 129-148, Cold Spring Harbor Monograph Series: v. 40
Xie, Ting; Spradling, Allan Book chapter

2000 1

A niche maintaining germ line stem cells in the Drosophila ovary
Science, v. 290, (5490), October 2000, p. 328-330
Xie, Ting; Spradling, Allan C. Article

1999 1

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation
Development, v. 126, (20), October 1999, p. 4477-4488
Liu, Zhao; Xie, Ting; Steward, Ruth Article

1998 1

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
Cell, v. 94, (2), July 1998, p. 251-260
Xie, Ting; Spradling, Allan C. Article

1997 1

The Drosophila germarium: Stem cells, germ line cysts, and oocytes
Cold Spring Harbor Symposia on Quantitative Biology, v. 62, 1997, p. 25-34
Spradling, A. C.; De Cuevas, M.; Drummond-Barbosa, D.; Keyes, L.; Lilly, M.; Pepling, M.; Xie, Ting Conference paper

1995 1

The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development
Genetics, v.141, (1), September 1995, p. 271-281
Finelli, Alyce L.; Xie, Ting; Bossie, Cynthia A.; Blackman, Ronald K.; Padgett, Richard W. Article

1994 2

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog
Development, v. 120, (4), April 1994, p. 861-870
Finelli, Alyce L.; Bossie, Cynthia A.; Xie, Ting; Padgett, Richard W. Article
The Drosophila saxophone gene: A serine-threonine kinase receptor of the TGF-β superfamily
Science, v. 263, (5154), March 1994, p. 1756-1759
Xie, Ting; Finelli, Alyce L.; Padgett, Richard W. Article


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Article 1

NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression
Cell Reports, v. 34, (2), January 2021, article number 108603
Pang, Ji; Le, Liang; Zhou, Yi; Tu, Renjun; Hou, Qiang; Tsuchiya, Dai; Thomas, Nancy; Wang, Yongfu; Yu, Zulin; Alexander, Richard; Thexton, Marina; Lewis, Brandy; Corbin, Timothy; Durnin, Michael; Li, Hua; Ashery-Padan, Ruth; Yan, Deyue; Xie, Ting


Expand All Collapse All


Article 3

Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation
Science Advances, v. 6, (20), May 2020, article number eaaz0480
Tu, Renjun; Duan, Bo; Song, Xiaoqing; Xie, Ting
Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs
Proceedings of the National Academy of Sciences of the United States of America, v. 117, (7), February 2020, p. 3603-3609
Zou, Fan; Tu, Renjun; Duan, Bo; Yang, Zhenlin; Ping, Zhaohua; Song, Xiaoqing; Chen, Shiyuan; Price, Andrew; Li, Hua; Scott, Allison; Perera, Anoja; Li, Sisi; Xie, Ting
Multiple niche compartments orchestrate stepwise germline stem cell progeny differentiation
Current Biology, v. 31, (4), 22 February 2021, p. 827-839.e3
Tu, Renjun; Duan, Bo; Song, Xiaoqing; Chen, Shiyuan; Scott, Allison; Hall, Kate; Blanck, Jillian; DeGraffenried, Dustin; Li, Hua; Perera, Anoja; Haug, Jeff; Xie, Ting


Expand All Collapse All


Article 3

Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen
Journal of Genetics and Genomics, v. 46, (1), January 2019, p. 19-30
Gao, Yuan; Mao, Ying; Xu, Rong-Gang; Zhu, Ruibao; Zhang, Ming; Sun, Jin; Shen, Da; Peng, Ping; Xie, Ting; Ni, Jian-Quan
Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells
Life Science Alliance, v. 2, (5), October 2019, article number e201800211
Story, Benjamin; Ma, Xing; Ishihara, Kazue; Li, Hua; Hall, Kathryn; Peak, Allison; Anoja, Perera; Park, Jungun; Haug, Jeff; Blanchette, Marco; Xie, Ting
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
Development, v. 146, (13), 28 June 2019, article number UNSP dev174615
Mao, Ying; Tu, Renjun; Huang, Yan; Mao, Decai; Yang, Zhihao; Lau, Pik Ki; Wang, Jinhui; Ni, Jianquan; Guo, Yusong; Xie, Ting


Expand All Collapse All


Article 1

Regional gene expression profile comparison reveals the unique transcriptome of the optic fissure
Investigative Ophthalmology and Visual Science, v. 59, (15), December 2018, p. 5773-5784
Cao, Mingzhe; Ouyang, Jiamin; Liang, Huilin; Guo, Jingyi; Lin, Siyuan; Yang, Shulan; Xie, Ting; Chen, Shuyi


Expand All Collapse All


Article 3

Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms
Developmental Cell, v. 41, (2), April 2017, p. 157-169.e5
Ma, Xing; Zhu, Xiujuan; Han, Yingying; Story, Benjamin; Do, Trieu; Song, Xiaoqing; Wang, Su; Zhang, Ying; Blanchette, Marco; Gogol, Madelaine; Hall, Kate; Peak, Allison; Anoja, Perera; Xie, Ting
Recapitulating and correcting marfan syndrome in a cellular model
International Journal of Biological Sciences, v. 13, (5), 2017, p. 588-603
Park, Jung Woo; Yan, Li; Stoddard, Chris; Wang, Xiaofang; Yue, Zhenwu; Crandall, Leann; Robinson, Tiwanna; Chang, Yuxiao; Denton, Kyle; Li, Enqin; Jiang, Bin; Zhang, Zhenwu; Martins-Taylor, Kristen; Yee, Siu-Pok; Nie, Hong; Gu, Feng; Si, Wei; Xie, Ting; Yue, Lixia; Xu, Ren-He
Trio-based exome sequencing arrests de novo mutations in early-onset high myopia
Proceedings of the National Academy of Sciences of the United States of America, v. 114, (16), April 2017, p. 4219-4224
Jin, Zi-Bing; Wu, Jinyu; Xie, Ting


Expand All Collapse All


Article 2

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Development (Cambridge), v. 143, (23), December 2016, p. 4312-4323
Ma, Xing; Han, Yingying; Song, Xiaoqing; Do, Trieu; Yang, Zhihao; Ni, Jianquan; Xie, Ting
Ocular stem cell research from basic science to clinical application: A report from zhongshan ophthalmic center ocular stem cell symposium
International Journal of Molecular Sciences, v. 17, (3), March 2016, article number 415
Ouyang, Hong; Goldberg, Jeffery L.; Chen, Shuyi; Li, Wei; Xu, Guo-Tong; Zhang, Kang; Nussenblatt, Robert B.; Liu, Yizhi; Xie, Ting; Chan, Chi-Chao; Zack, Donald J.


Expand All Collapse All


Article 6

COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary
Development (Cambridge), v. 142, (24), December 2015, p. 4242-4252
Lu, Tinglin; Wang, Su; Gao, Yuan; Mao, Ying; Yang, Zhihao; Liu, Luping; Song, Xiaoqing; Ni, Jianquan; Xie, Ting
Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state
Journal of Biological Chemistry, v. 290, (37), September 2015, p. 22782-22794
Ouyang, Juan; Yu, Wei; Liu, Jing; Zhang, Nian; Florens, Laurence; Chen, Jiekai; Liu, He; Washburn, Michael; Pei, Duanqing; Xie, Ting
Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation
Nature Communications, v. 6, November 2015, article number 8856
Sun, Jin; Wei, Hui-Min; Xu, Jiang; Chang, Jian-Feng; Yang, Zhihao; Ren, Xingjie; Lv, Wen-Wen; Liu, Lu-Ping; Pan, Li-Xia; Wang, Xia; Qiao, Huan-Huan; Zhu, Bing; Ji, Jun-Yuan; Yan, Dong; Xie, Ting; Sun, Fang-Lin; Ni, Jian-Quan
Responses of Multipotent Retinal Stem Cells to IL-1 β, IL-18, or IL-17
Journal of Ophthalmology, v. 2015, 2015, article number 369312
Chen, Shida; Shen, Defen; Popp, Nicholas A.; Ogilvy, Alexander J.; Tuo, Jingsheng; Abu-Asab, Mones; Xie, Ting; Chan, Chi-Chao
Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways
Cell Reports, v. 13, (7), November 2015, p. 1366-1379
Fu, Ziwen; Geng, Cuiyun; Wang, Hui; Yang, Zhihao; Weng, Changjiang; Li, Hua; Deng, Lamei; Liu, Luping; Liu, Nan; Ni, Jianquang; Xie, Ting
Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche
eLife, v. 4, October 2015, article number e08174
Wang, Su; Gao, Yuan; Song, Xiaoqing; Ma, Xing; Zhu, Xiujuan; Mao, Ying; Yang, Zhihao; Ni, Jianquan; Li, Hua; Malanowski, Kathryn E.; Anoj, Perera; Park, Jungeun; Haug, Jeff; Xie, Ting


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Article 4

A regulatory network of Drosophila germline stem cell self-renewal
Developmental Cell, v. 28, (4), February 2014, p. 459-473
Yan, Dong; Neumüller, Ralph A.; Buckner, Michael; Ayers, Kathleen; Li, Hua; Hu, Yanhui; Yang-Zhou, Donghui; Pan, Lei; Wang, Xiaoxi; Kelley, Colleen; Vinayagam, Arunachalam; Binari, Richard; Randklev, Sakara; Perkins, Lizabeth A.; Xie, Ting; Cooley, Lynn; Perrimon, Norbert
Extracellular, stem cells and regenerative ophthalmology
Journal of Glaucoma, v. 23, (8), December 2014, p. S30-S33
Wang, Yifeng; Xie, Ting
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary
PLoS ONE, v. 9, (3), March 2014, article number e90267
Ma, Xing; Wang, Su; Do, Trieu; Song, Xioaqing; Inaba, Mayu; Nishimoto, Yoshiya; Liu, Lu-Ping; Gao, Yuan; Mao, Ying; Li, Hui; McDowell, William; Park, Jungeun; Malanowski, Kate; Peak, Allison; Perera, Anoja; Li, Hua; Gaudenz, Karin; Haug, Jeff; Yamashita, Yukiko; Lin, Haifan; Ni, Jian-Quan; Xie, Ting
Protein competition switches the function of COP9 from self-renewal to differentiation
Nature, v. 514, (7521), October 2014, p. 233-236
Pan, Lei; Wang, Su; Lu, Tinglin; Weng, Changjiang; Song, Xiaoqing; Park, Joseph K.; Sun, Jin; Yang, Zhi-Hao; Yu, Junjing; Tang, Hong; McKearin, Dennis M.; Chamovitz, Daniel A.; Ni, Jianquan; Xie, Ting


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Article 7

Adhesion in the stem cell niche: Biological roles and regulation
Development (Cambridge), v. 140, (2), January 2013, p. 255-265
Chen, Shuyi; Lewallen, Michelle; Xie, Ting
Cell-based therapies for retinal degenerative diseases: A thousand strategies
Journal of Glaucoma, v. 22, (5 SUPPL.1), June 2013, p. S42-S45
Lewallen, Michelle; Xie, Ting
Control of germline stem cell self-renewal and differentiation in the Drosophila ovary: concerted actions of niche signals and intrinsic factors
Wiley Interdisciplinary Review-Developmental Biology, v. 2, (2), Mar-Apr 2013, p. 261-273
Xie, Ting
Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis
Cell Research, v. 23, (2), February 2013, p. 254-273
Chen, Shuyi; Li, Hua; Gaudenz, Karin; Paulson, Ariel; Guo, Fengli; Trimble, Rhonda; Peak, Allison; Seidel, Christopher; Deng, Chuxia; Furuta, Yasuhide; Xie, Ting
Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells
Cell Research, v. 23, (6), June 2013, p. 788-802
Li, Tianqing; Lewallen, Michelle; Chen, Shuyi; Yu, Wei; Zhang, Nian; Xie, Ting
Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (22), May 2013, p. 8966-8971
Zhou, Yi; Tanzie, Christopher; Yan, Zhipeng; Chen, Shuyi; Duncan, Michael; Gaudenz, Karin; Li, Hua; Seidel, Christopher; Lewis, Brandy; Moran, Andrea; Libby, Richard T.; Kiernan, Amy E.; Xie, Ting
Stem Cells' Exodus: A Journey to Immortality
Developmental Cell, v. 24, (2), January 2013, p. 113-114
Zhou, Yi; Lewallen, Michelle; Xie, Ting


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Article 2

Cadherin-Mediated Cell Adhesion Is Critical for the Closing of the Mouse Optic Fissure
PLoS ONE, v. 7, (12), December 2012, article number e51705
Chen, Shuyi; Lewis, Brandy; Moran, Andrea; Xie, Ting
Mathematical Model for Two Germline Stem Cells Competing for Niche Occupancy
Bulletin of Mathematical Biology, v. 74, (5), May 2012, p. 1207-1225
Tian, Jianjun P.; Jin, Zhigang; Xie, Ting


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Article 5

A PGC-1 tale: Healthier intestinal stem cells, longer life
Cell Metabolism, v. 14, (5), November 2011, p. 571-572
Zhou, Yi; Lu, Tu; Xie, Ting
Histone H3K9 trimethylase eggless controls germline stem cell maintenance and differentiation
PLoS Genetics, v. 7, (12), December 2011, article number e1002426
Wang, Xiaoxi; Pan, Lei; Wang, Su; Zhou, Jian; McDowell, William; Park, Jungeun; Haug, Jeff; Staehling, Karen; Tang, Hong; Xie, Ting
Restricting self-renewal signals within the stem cell niche: Multiple levels of control
Current Opinion in Genetics and Development, v. 21, (6), December 2011, p. 684-689
Chen, Shuyi; Wang, Su; Xie, Ting
Self-maintained escort cells form a germline stem cell differentiation niche
Development, v. 138, (23), December 2011, p. 5087-5097
Kirilly, Daniel; Wang, Su; Xie, Ting
Stem cells: Keeping BMP signaling local
Current Biology, v. 21, (19), October 2011, p. R809-R811
Ma, Xing; Xie, Ting


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Article 1

Lissencephaly-1 controls germline stem cell self- renewal through modulating bone morphogenetic protein signaling and niche adhesion
Journal of Molecular Cell Biology, v. 107, (46), November 2010, p. 19939-19944
Chen, Shuyi; Kaneko, Satoshi; Ma, Xing; Chen, Xiaochu; Ip, Y. Tony; Xu, Lan; Xie, Ting


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Article 2

eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary
Proceedings of the National Academy of Sciences of the United States of America, v. 106, (28), July 2009, p. 11623-11628
Shen, Run; Weng, Changjiang; Yu, Junjing; Xie, Ting
Stem Cell in the Adult Drosophila Hindgut: Just a Sleeping Beauty
Cell Stem Cell, v. 5, (3), September 2009, p. 227-228
Xie, Ting


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Article 4

Differentiation-Defective Stem Cells Outcompete Normal Stem Cells for Niche Occupancy in the Drosophila Ovary
Cell Stem Cell, v. 2, (1), January 2008, p. 39-49
Jin, Zhigang; Kirilly, Daniel; Weng, Changjiang; Kawase, Eihachiro; Song, Xiaoqing; Smith, Sarah; Schwartz, Joel; Xie, Ting
Germline Stem Cell Niches
StemBook, 30 September 2008, article number 497
Xie, Ting
Physiology: Burn fat, live longer
Science, v. 322, (5903), November 2008, p. 865-866
Xie, Ting
Stem cell self-renewal versus differentiation: Tumor suppressor Mei-P26 and miRNAs control the balance
Cell Research, v. 18, (7), July 2008, p. 713-715
Shen, Run; Xie, Ting

Book chapter 1

Extrinsic and intrinsic control of germline stem cell regulation in the Drosophila ovary
Regulatory Networks in Stem Cells / Vinagolu K. Rajasekhar, Mohan C. Vemuri (eds.). New York, NY : Humana Press, 2009, p. 155-164, Book series: Stem Cell Biology and Regenerative Medicine
Zhang, Ning; Xie, Ting

Conference paper 1

Interactions between stem cells and their niche in the Drosophila ovary
Cold Spring Harbor Symposia on Quantitative Biology, v. 73, 2008, p. 39-47
Xie, Ting; Song, X.; Jin, Z.; Pan, L.; Weng, C.; Chen, S.; Zhang, N.


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Article 5

Dcr-1 Maintains Drosophila Ovarian Stem Cells
Current Biology, v. 17, (6), March 2007, p. 539-544
Jin, Zhigang; Xie, Ting
Notch signaling controls germline stem cell niche formation in the Drosophila ovary
Development, v. 134, (6), March 2007, p. 1071-1080
Song, Xiaoqing; Call, Gerald B.; Kirilly, Daniel; Xie, Ting
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Cell Stem Cell, v. 1, (4), October 2007, p. 458-469
Pan, Lei; Chen, Shuyi; Weng, Changjiang; Call, Gerald; Zhu, Dongxiao; Tang, Hong; Zhang, Nian; Xie, Ting
Stem cells and their niche: An inseparable relationship
Development, v. 134, (11), June 2007, p. 2001-2006
Xie, Ting; Li, Linheng
The Drosophila ovary: An active stem cell community
Cell Research, v. 17, (1), January 2007, p. 15-25
Kirilly, Daniel; Xie, Ting


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Article 1

Germline Specification: Small Things Have a Big Role
Current Biology, v. 16, (22), November 2006, p. R966-R967
Jin, Zhigang; Xie, Ting


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Article 7

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary
Developmental Cell, v. 9, (5), November 2005, p. 651-662
Kirilly, Daniel; Spana, Eric P.; Perrimon, Norbert; Padgett, Richard W.; Xie, Ting
Intimate relationships with their neighbors: Tales of stem cells in Drosophila reproductive systems
Developmental Dynamics, v. 232, (3), March 2005, p. 775-790
Xie, Ting; Kawase, Eihachiro; Kirilly, Daniel; Wong, Marco D.
Molecular mechanisms controlling germline and somatic stem cells: Similarities and differences
Current Opinion in Genetics and Development, v. 15, (4), August 2005, p. 381-387
Xi, Rongwen; Kirilly, Daniel; Xie, Ting
Molecular mechanisms of germline stem cell regulation
Annual Review of Genetics, v. 39, December 2005, p. 173-195
Wong, Marco D.; Jin, Zhigang; Xie, Ting
Pelota controls self-renewal of germline stem cells by repsessing a Bam-independent differentiation pathway
Development, v. 132, (24), 2005, p. 5365-5374
Xi, Rongwen; Doan, Choung; Liu, Dazhi; Xie, Ting
Stem cell niche: Structure and function
Annual Review of Cell and Developmental Biology, v. 21, November 2005, p. 605-631
Li, Linheng; Xie, Ting
Stem cell self-renewal controlled by chromatin remodeling factors
Science, v. 310, (5753), December 2005, p. 1487-1489
Xi, Rongwen; Xie, Ting


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Article 2

Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
Development, v. 131, (6), March 2004, p. 1353-1364
Song, Xiaoqing; Wong, Marco D.; Kawase, Eihachiro; Xi, Rongwen; Ding, Bee C.; McCarthy, John J.; Xie, Ting
Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
Development, v. 131, (6), March 2004, p. 1365-1375
Kawase, Eihachiro; Wong, Marco D.; Ding, Bee C.; Xie, Ting


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Article 2

Clonal expansion of ovarian germline stem cells during niche formation in Drosophila
Development, v. 130, (12), June 2003, p. 2579-2588
Zhu, Chun-Hong; Xie, Ting
Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila
Development, v. 130, (14), July 2003, p. 3259-3268
Song, Xiaoqing; Xie, Ting


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Article 2

DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary
Proceedings of the National Academy of Sciences of the United States of America, v. 99, (23), November 2002, p. 14813-14818
Song, Xiaoqing; Xie, Ting
Germline stem cells anchored by adherens junctions in the Drosophila ovary niches
Science, v. 296, (5574), June 2002, p. 1855-1857
Song, Xiaoqing; Zhu, Chun-Hong; Doan, Chuong; Xie, Ting


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Book chapter 1

The Drosophila ovary: An in vivo stem cell system
Stem Cell Biology / Edited by Daniel R. Marshak, Richard L. Gardner,David Gottlieb. Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, 2001, p. 129-148, Cold Spring Harbor Monograph Series: v. 40
Xie, Ting; Spradling, Allan


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Article 1

A niche maintaining germ line stem cells in the Drosophila ovary
Science, v. 290, (5490), October 2000, p. 328-330
Xie, Ting; Spradling, Allan C.


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Article 1

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation
Development, v. 126, (20), October 1999, p. 4477-4488
Liu, Zhao; Xie, Ting; Steward, Ruth


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Article 1

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
Cell, v. 94, (2), July 1998, p. 251-260
Xie, Ting; Spradling, Allan C.


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Conference paper 1

The Drosophila germarium: Stem cells, germ line cysts, and oocytes
Cold Spring Harbor Symposia on Quantitative Biology, v. 62, 1997, p. 25-34
Spradling, A. C.; De Cuevas, M.; Drummond-Barbosa, D.; Keyes, L.; Lilly, M.; Pepling, M.; Xie, Ting


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Article 1

The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development
Genetics, v.141, (1), September 1995, p. 271-281
Finelli, Alyce L.; Xie, Ting; Bossie, Cynthia A.; Blackman, Ronald K.; Padgett, Richard W.


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Article 2

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog
Development, v. 120, (4), April 1994, p. 861-870
Finelli, Alyce L.; Bossie, Cynthia A.; Xie, Ting; Padgett, Richard W.
The Drosophila saxophone gene: A serine-threonine kinase receptor of the TGF-β superfamily
Science, v. 263, (5154), March 1994, p. 1756-1759
Xie, Ting; Finelli, Alyce L.; Padgett, Richard W.


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2016 2

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Development (Cambridge), v. 143, (23), December 2016, p. 4312-4323
Ma, Xing; Han, Yingying; Song, Xiaoqing; Do, Trieu; Yang, Zhihao; Ni, Jianquan; Xie, Ting Article
Ocular stem cell research from basic science to clinical application: A report from zhongshan ophthalmic center ocular stem cell symposium
International Journal of Molecular Sciences, v. 17, (3), March 2016, article number 415
Ouyang, Hong; Goldberg, Jeffery L.; Chen, Shuyi; Li, Wei; Xu, Guo-Tong; Zhang, Kang; Nussenblatt, Robert B.; Liu, Yizhi; Xie, Ting; Chan, Chi-Chao; Zack, Donald J. Article

2015 6

COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary
Development (Cambridge), v. 142, (24), December 2015, p. 4242-4252
Lu, Tinglin; Wang, Su; Gao, Yuan; Mao, Ying; Yang, Zhihao; Liu, Luping; Song, Xiaoqing; Ni, Jianquan; Xie, Ting Article
Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state
Journal of Biological Chemistry, v. 290, (37), September 2015, p. 22782-22794
Ouyang, Juan; Yu, Wei; Liu, Jing; Zhang, Nian; Florens, Laurence; Chen, Jiekai; Liu, He; Washburn, Michael; Pei, Duanqing; Xie, Ting Article
Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation
Nature Communications, v. 6, November 2015, article number 8856
Sun, Jin; Wei, Hui-Min; Xu, Jiang; Chang, Jian-Feng; Yang, Zhihao; Ren, Xingjie; Lv, Wen-Wen; Liu, Lu-Ping; Pan, Li-Xia; Wang, Xia; Qiao, Huan-Huan; Zhu, Bing; Ji, Jun-Yuan; Yan, Dong; Xie, Ting; Sun, Fang-Lin; Ni, Jian-Quan Article
Responses of Multipotent Retinal Stem Cells to IL-1 β, IL-18, or IL-17
Journal of Ophthalmology, v. 2015, 2015, article number 369312
Chen, Shida; Shen, Defen; Popp, Nicholas A.; Ogilvy, Alexander J.; Tuo, Jingsheng; Abu-Asab, Mones; Xie, Ting; Chan, Chi-Chao Article
Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways
Cell Reports, v. 13, (7), November 2015, p. 1366-1379
Fu, Ziwen; Geng, Cuiyun; Wang, Hui; Yang, Zhihao; Weng, Changjiang; Li, Hua; Deng, Lamei; Liu, Luping; Liu, Nan; Ni, Jianquang; Xie, Ting Article
Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche
eLife, v. 4, October 2015, article number e08174
Wang, Su; Gao, Yuan; Song, Xiaoqing; Ma, Xing; Zhu, Xiujuan; Mao, Ying; Yang, Zhihao; Ni, Jianquan; Li, Hua; Malanowski, Kathryn E.; Anoj, Perera; Park, Jungeun; Haug, Jeff; Xie, Ting Article

2014 4

A regulatory network of Drosophila germline stem cell self-renewal
Developmental Cell, v. 28, (4), February 2014, p. 459-473
Yan, Dong; Neumüller, Ralph A.; Buckner, Michael; Ayers, Kathleen; Li, Hua; Hu, Yanhui; Yang-Zhou, Donghui; Pan, Lei; Wang, Xiaoxi; Kelley, Colleen; Vinayagam, Arunachalam; Binari, Richard; Randklev, Sakara; Perkins, Lizabeth A.; Xie, Ting; Cooley, Lynn; Perrimon, Norbert Article
Extracellular, stem cells and regenerative ophthalmology
Journal of Glaucoma, v. 23, (8), December 2014, p. S30-S33
Wang, Yifeng; Xie, Ting Article
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary
PLoS ONE, v. 9, (3), March 2014, article number e90267
Ma, Xing; Wang, Su; Do, Trieu; Song, Xioaqing; Inaba, Mayu; Nishimoto, Yoshiya; Liu, Lu-Ping; Gao, Yuan; Mao, Ying; Li, Hui; McDowell, William; Park, Jungeun; Malanowski, Kate; Peak, Allison; Perera, Anoja; Li, Hua; Gaudenz, Karin; Haug, Jeff; Yamashita, Yukiko; Lin, Haifan; Ni, Jian-Quan; Xie, Ting Article
Protein competition switches the function of COP9 from self-renewal to differentiation
Nature, v. 514, (7521), October 2014, p. 233-236
Pan, Lei; Wang, Su; Lu, Tinglin; Weng, Changjiang; Song, Xiaoqing; Park, Joseph K.; Sun, Jin; Yang, Zhi-Hao; Yu, Junjing; Tang, Hong; McKearin, Dennis M.; Chamovitz, Daniel A.; Ni, Jianquan; Xie, Ting Article

2013 7

Adhesion in the stem cell niche: Biological roles and regulation
Development (Cambridge), v. 140, (2), January 2013, p. 255-265
Chen, Shuyi; Lewallen, Michelle; Xie, Ting Article
Cell-based therapies for retinal degenerative diseases: A thousand strategies
Journal of Glaucoma, v. 22, (5 SUPPL.1), June 2013, p. S42-S45
Lewallen, Michelle; Xie, Ting Article
Control of germline stem cell self-renewal and differentiation in the Drosophila ovary: concerted actions of niche signals and intrinsic factors
Wiley Interdisciplinary Review-Developmental Biology, v. 2, (2), Mar-Apr 2013, p. 261-273
Xie, Ting Article
Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis
Cell Research, v. 23, (2), February 2013, p. 254-273
Chen, Shuyi; Li, Hua; Gaudenz, Karin; Paulson, Ariel; Guo, Fengli; Trimble, Rhonda; Peak, Allison; Seidel, Christopher; Deng, Chuxia; Furuta, Yasuhide; Xie, Ting Article
Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells
Cell Research, v. 23, (6), June 2013, p. 788-802
Li, Tianqing; Lewallen, Michelle; Chen, Shuyi; Yu, Wei; Zhang, Nian; Xie, Ting Article
Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (22), May 2013, p. 8966-8971
Zhou, Yi; Tanzie, Christopher; Yan, Zhipeng; Chen, Shuyi; Duncan, Michael; Gaudenz, Karin; Li, Hua; Seidel, Christopher; Lewis, Brandy; Moran, Andrea; Libby, Richard T.; Kiernan, Amy E.; Xie, Ting Article
Stem Cells' Exodus: A Journey to Immortality
Developmental Cell, v. 24, (2), January 2013, p. 113-114
Zhou, Yi; Lewallen, Michelle; Xie, Ting Article

2012 2

Cadherin-Mediated Cell Adhesion Is Critical for the Closing of the Mouse Optic Fissure
PLoS ONE, v. 7, (12), December 2012, article number e51705
Chen, Shuyi; Lewis, Brandy; Moran, Andrea; Xie, Ting Article
Mathematical Model for Two Germline Stem Cells Competing for Niche Occupancy
Bulletin of Mathematical Biology, v. 74, (5), May 2012, p. 1207-1225
Tian, Jianjun P.; Jin, Zhigang; Xie, Ting Article

2011 5

A PGC-1 tale: Healthier intestinal stem cells, longer life
Cell Metabolism, v. 14, (5), November 2011, p. 571-572
Zhou, Yi; Lu, Tu; Xie, Ting Article
Histone H3K9 trimethylase eggless controls germline stem cell maintenance and differentiation
PLoS Genetics, v. 7, (12), December 2011, article number e1002426
Wang, Xiaoxi; Pan, Lei; Wang, Su; Zhou, Jian; McDowell, William; Park, Jungeun; Haug, Jeff; Staehling, Karen; Tang, Hong; Xie, Ting Article
Restricting self-renewal signals within the stem cell niche: Multiple levels of control
Current Opinion in Genetics and Development, v. 21, (6), December 2011, p. 684-689
Chen, Shuyi; Wang, Su; Xie, Ting Article
Self-maintained escort cells form a germline stem cell differentiation niche
Development, v. 138, (23), December 2011, p. 5087-5097
Kirilly, Daniel; Wang, Su; Xie, Ting Article
Stem cells: Keeping BMP signaling local
Current Biology, v. 21, (19), October 2011, p. R809-R811
Ma, Xing; Xie, Ting Article

2010 1

Lissencephaly-1 controls germline stem cell self- renewal through modulating bone morphogenetic protein signaling and niche adhesion
Journal of Molecular Cell Biology, v. 107, (46), November 2010, p. 19939-19944
Chen, Shuyi; Kaneko, Satoshi; Ma, Xing; Chen, Xiaochu; Ip, Y. Tony; Xu, Lan; Xie, Ting Article

2009 2

eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary
Proceedings of the National Academy of Sciences of the United States of America, v. 106, (28), July 2009, p. 11623-11628
Shen, Run; Weng, Changjiang; Yu, Junjing; Xie, Ting Article
Stem Cell in the Adult Drosophila Hindgut: Just a Sleeping Beauty
Cell Stem Cell, v. 5, (3), September 2009, p. 227-228
Xie, Ting Article

2008 6

Differentiation-Defective Stem Cells Outcompete Normal Stem Cells for Niche Occupancy in the Drosophila Ovary
Cell Stem Cell, v. 2, (1), January 2008, p. 39-49
Jin, Zhigang; Kirilly, Daniel; Weng, Changjiang; Kawase, Eihachiro; Song, Xiaoqing; Smith, Sarah; Schwartz, Joel; Xie, Ting Article
Germline Stem Cell Niches
StemBook, 30 September 2008, article number 497
Xie, Ting Article
Physiology: Burn fat, live longer
Science, v. 322, (5903), November 2008, p. 865-866
Xie, Ting Article
Stem cell self-renewal versus differentiation: Tumor suppressor Mei-P26 and miRNAs control the balance
Cell Research, v. 18, (7), July 2008, p. 713-715
Shen, Run; Xie, Ting Article
Extrinsic and intrinsic control of germline stem cell regulation in the Drosophila ovary
Regulatory Networks in Stem Cells / Vinagolu K. Rajasekhar, Mohan C. Vemuri (eds.). New York, NY : Humana Press, 2009, p. 155-164, Book series: Stem Cell Biology and Regenerative Medicine
Zhang, Ning; Xie, Ting Book chapter
Interactions between stem cells and their niche in the Drosophila ovary
Cold Spring Harbor Symposia on Quantitative Biology, v. 73, 2008, p. 39-47
Xie, Ting; Song, X.; Jin, Z.; Pan, L.; Weng, C.; Chen, S.; Zhang, N. Conference paper

2007 5

Dcr-1 Maintains Drosophila Ovarian Stem Cells
Current Biology, v. 17, (6), March 2007, p. 539-544
Jin, Zhigang; Xie, Ting Article
Notch signaling controls germline stem cell niche formation in the Drosophila ovary
Development, v. 134, (6), March 2007, p. 1071-1080
Song, Xiaoqing; Call, Gerald B.; Kirilly, Daniel; Xie, Ting Article
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Cell Stem Cell, v. 1, (4), October 2007, p. 458-469
Pan, Lei; Chen, Shuyi; Weng, Changjiang; Call, Gerald; Zhu, Dongxiao; Tang, Hong; Zhang, Nian; Xie, Ting Article
Stem cells and their niche: An inseparable relationship
Development, v. 134, (11), June 2007, p. 2001-2006
Xie, Ting; Li, Linheng Article
The Drosophila ovary: An active stem cell community
Cell Research, v. 17, (1), January 2007, p. 15-25
Kirilly, Daniel; Xie, Ting Article

2006 1

Germline Specification: Small Things Have a Big Role
Current Biology, v. 16, (22), November 2006, p. R966-R967
Jin, Zhigang; Xie, Ting Article

2005 7

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary
Developmental Cell, v. 9, (5), November 2005, p. 651-662
Kirilly, Daniel; Spana, Eric P.; Perrimon, Norbert; Padgett, Richard W.; Xie, Ting Article
Intimate relationships with their neighbors: Tales of stem cells in Drosophila reproductive systems
Developmental Dynamics, v. 232, (3), March 2005, p. 775-790
Xie, Ting; Kawase, Eihachiro; Kirilly, Daniel; Wong, Marco D. Article
Molecular mechanisms controlling germline and somatic stem cells: Similarities and differences
Current Opinion in Genetics and Development, v. 15, (4), August 2005, p. 381-387
Xi, Rongwen; Kirilly, Daniel; Xie, Ting Article
Molecular mechanisms of germline stem cell regulation
Annual Review of Genetics, v. 39, December 2005, p. 173-195
Wong, Marco D.; Jin, Zhigang; Xie, Ting Article
Pelota controls self-renewal of germline stem cells by repsessing a Bam-independent differentiation pathway
Development, v. 132, (24), 2005, p. 5365-5374
Xi, Rongwen; Doan, Choung; Liu, Dazhi; Xie, Ting Article
Stem cell niche: Structure and function
Annual Review of Cell and Developmental Biology, v. 21, November 2005, p. 605-631
Li, Linheng; Xie, Ting Article
Stem cell self-renewal controlled by chromatin remodeling factors
Science, v. 310, (5753), December 2005, p. 1487-1489
Xi, Rongwen; Xie, Ting Article

2004 2

Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
Development, v. 131, (6), March 2004, p. 1353-1364
Song, Xiaoqing; Wong, Marco D.; Kawase, Eihachiro; Xi, Rongwen; Ding, Bee C.; McCarthy, John J.; Xie, Ting Article
Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
Development, v. 131, (6), March 2004, p. 1365-1375
Kawase, Eihachiro; Wong, Marco D.; Ding, Bee C.; Xie, Ting Article

2003 2

Clonal expansion of ovarian germline stem cells during niche formation in Drosophila
Development, v. 130, (12), June 2003, p. 2579-2588
Zhu, Chun-Hong; Xie, Ting Article
Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila
Development, v. 130, (14), July 2003, p. 3259-3268
Song, Xiaoqing; Xie, Ting Article

2002 2

DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary
Proceedings of the National Academy of Sciences of the United States of America, v. 99, (23), November 2002, p. 14813-14818
Song, Xiaoqing; Xie, Ting Article
Germline stem cells anchored by adherens junctions in the Drosophila ovary niches
Science, v. 296, (5574), June 2002, p. 1855-1857
Song, Xiaoqing; Zhu, Chun-Hong; Doan, Chuong; Xie, Ting Article

2001 1

The Drosophila ovary: An in vivo stem cell system
Stem Cell Biology / Edited by Daniel R. Marshak, Richard L. Gardner,David Gottlieb. Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, 2001, p. 129-148, Cold Spring Harbor Monograph Series: v. 40
Xie, Ting; Spradling, Allan Book chapter

2000 1

A niche maintaining germ line stem cells in the Drosophila ovary
Science, v. 290, (5490), October 2000, p. 328-330
Xie, Ting; Spradling, Allan C. Article

1999 1

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation
Development, v. 126, (20), October 1999, p. 4477-4488
Liu, Zhao; Xie, Ting; Steward, Ruth Article

1998 1

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
Cell, v. 94, (2), July 1998, p. 251-260
Xie, Ting; Spradling, Allan C. Article

1997 1

The Drosophila germarium: Stem cells, germ line cysts, and oocytes
Cold Spring Harbor Symposia on Quantitative Biology, v. 62, 1997, p. 25-34
Spradling, A. C.; De Cuevas, M.; Drummond-Barbosa, D.; Keyes, L.; Lilly, M.; Pepling, M.; Xie, Ting Conference paper

1995 1

The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development
Genetics, v.141, (1), September 1995, p. 271-281
Finelli, Alyce L.; Xie, Ting; Bossie, Cynthia A.; Blackman, Ronald K.; Padgett, Richard W. Article

1994 2

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog
Development, v. 120, (4), April 1994, p. 861-870
Finelli, Alyce L.; Bossie, Cynthia A.; Xie, Ting; Padgett, Richard W. Article
The Drosophila saxophone gene: A serine-threonine kinase receptor of the TGF-β superfamily
Science, v. 263, (5154), March 1994, p. 1756-1759
Xie, Ting; Finelli, Alyce L.; Padgett, Richard W. Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 3 2020-21 Summer 2 2020-21 Spring 0 2020-21 Winter 0 2020-21 Fall 0

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LIFS4910A Independent Study
UROP1100E Undergraduate Research Opportunities Series 1
UROP2100E Undergraduate Research Opportunities Series 2


UROP1000 Undergraduate Research Opportunities
UROP1100D Undergraduate Research Opportunities Series 1


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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Current RPGs

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Doctor of Philosophy PHAM BINH, Minh
Life Science( 2021 - )

QIN, Ya
Life Science( 2021 - )

XIAO, Nan
Life Science( 2021 - )

YAN, Jia
Life Science( 2021 - )

ZHENG, Min
Life Science( 2021 - )

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Master of Philosophy HE, Zonglin
Life Science( 2021 - )









ProjectsFrom January 2020 to December 2022

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All Projects 2

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No Projects.
Stem cell-niche interactions in tissue maintenance and engineering


干细胞与微环境互作在组织维持和组织工程中的应用 Leading


RGC - Theme-based Research Scheme


Project Team (HKUST)
XIE Ting (Lead)
CHEUNG Tom
GUO Yusong
LEUNG Danny Chi Yeu
LIU Kai
MAK Ho Yi
SUN Fei
WEN Zilong
WU Angela Ruohao
WU Zhenguo
YAN Yan


2022 -




Investigating the functions of Elavl family protein Rbp9 in germline stem cell differentiation in the Drosophila ovary


探究Elav1家族蛋白Rbp9在果蝇卵巢生殖干细胞分化过程中的功能 Leading


RGC - General Research Fund


Project Team (HKUST)
XIE Ting (Lead)


2021 -