王凱亮博士教學科研部助理教授
xavierwong@hkbu.edu.hk

王凱亮博士分別於2009年和2013年在香港大學獲得生物化學學士學位及博士學位，畢業後曾在香港大學生物醫學學院和香港中文大學從事博士後研究，於2016年加入香港浸會大學中醫藥學院擔任研究助理教授，2020年晉升為助理教授。
王博士致力於探索細胞外基質及膜型基質金屬蛋白酶在發育過程中的調節機制，並揭示了MT1-MMP在多種信號通路調節中的主導作用。他還集中研究幹細胞在發育過程和疾病中的重要性，分別在Developmental Cell 、Nature Communications、The EMBO Journal、 Microbiome、Cell Death & Disease等國際著名的核心期刊上發表了研究論文和評論文章。
主要研究：
1. 細胞外基質在發育過程和疾病中的調節機制
2. 幹細胞自我更新和分化在發育和疾病中的重要性
3. 中藥化合物在代謝疾病治療中的作用
***誠摯邀請研究生，博士後研究員和研究助理加入我們的團隊。有關職位的查詢，請聯繫王博士(電子郵件：xavierwong@hkbu.edu.hk) 。
精選出版物Representative publications
1. Guo X, Zhang S, Wong SKK, Fallah S, Chow CFW, Asthana P, Che S, Zhai L, Wang Z, Xin G, Jiang Z, Gurung S, Wu J, Zhang Y, Wu X, Xu K, Lin CY, Kwan HY, Lyu A, Zhou Z, Bian Z, Wong HLX Regulation of ageing-associated insulin resistance by MT1-MMP-mediated cleavage of Insulin Receptor (under major revision in Nature Communications) [5-year Impact factor: 15.805]
2. Chow CFW, Zhang S, Fallah S, Che S, Guo X, Wang Z, Ge X, Jiang Z, Zhai L, Lin CY, Kwan HY, Huang T, Lyu A, Zhou Z, Bian Z, Wong HLX, (2021) Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nature Metabolism (accepted) [2-year Impact factor: 13.511]
3. Wong HLX, Qin H, Tsang SW, Zuo X, Che S, Chow CFW, Li X. Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian Z (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1):1745 [5-year Impact factor: 15.805]
4. Wong HLX, Jin G, Zhang S, Cao R, Cao Y, Zhou Z (2016) MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nature Communications 7:10824 [5-year Impact factor: 15.805]
5. Chan KM*, Wong HLX* (*co-first), Jin G, Liu B, Cao R, Cao Y, Lehtl K, Tryggvason K and Zhou Z (2012). MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling in calvarial osteogenesis. Developmental Cell, 22(6); 1176-1190 [5-year Impact factor: 12.332]
[recommended in F1000 Prime, F1000 factor 8.0]
Other publications
1. Zhai L, Wu J, Kwan HY, Bian Z, Wong HLX. (2021) Gut-Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes. International Journal of Molecular Sciences [Impact factor: 5.924]
2. Chen MT, Zhong KY, Tan JC, Meng MJ, Liu CM, Chen B, Huang CH, Wong HLX, Bian ZX, Su T, Kwan HY. (2021) Baicalein directly binds to toll like receptor 4 and inhibits colorectal cancer growth and metastasis via the TLR4/HIF/VEGF axis. Clinical and Translational Medicine [Impact factor: 11.492]
3. Hu XJ, Fatima S, Huang T, Chen MT, Gong RH, Ho AHM, Wong HLX, Yu RM, Song L, Kwan HY, Bian ZX. (2021) Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc. Cell Death & Disease [Impact factor: 8.469]
4. Hu XJ, Fatima S, Chen MT, Huang CH, Ho AHM, Gong RH, Su T, Wong HLX, Bian ZX, Kwan HY. (2021) High fat diet increases colorectal cancer growth: Role of toll-like receptor 4. Cell Death & Disease 12(8):791 [Impact factor: 8.469]
5. Chen M, Wu HL, Wong TS, Chen B, Gong RH, Wong HLX, Xiao H, Bian Z, Kwan HY. (2021) Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor alpha and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis. Front Pharmacol 12, 657080, doi:10.3389/fphar.2021.657080 [Impact factor: 5.81]
6. Li X, Huang T, Xiao ΗΤ, Wu PG, Lin C, Ning Z, Zhao L, Kwan HY, Hu XJ, Wong HLX, Li XQ, Bian Z (2020) Berberine suppresses colonic inflammation in DSS-induced murine colitis through inhibition of cytosolic phospholipase A2 activity, Frontiers in Pharmacology [Impact factor: 5.81]
7. Qin HY, Wong HLX, Zang KH, Li X, Bian Z (2019) Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues, Life Sciences, 116886, [Impact factor: 5.037]
8. Fatima S, Hu X, Huang C, Zhang W, Cai J, Huang M, Gong RH, Chen M, Ho AHM, Su T, Wong HLX, Bian Z, Kwan HY (2019) High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner Cell Death & Disease 10, 711, [Impact factor: 8.469]
9. Kwan HY, Liu B, Huang C, Fatima S, Su T, Ho AHM, Han Q, Hu X, Gong RH, Chen M, Wong HLX, Bian Z (2019) Signal transducer and activator of transcription-3 (STAT-3) drives the high fat diet-associated prostate cancer growth. Cell Death & Disease 10, 637, [Impact factor: 8.469]
10. Chow CFW, Che S, Qin HY, Kwan HY, Bian Z, Wong HLX (2019) From psychology to physicality: How Nerve Growth Factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle 18, 1824-1829 [Impact factor: 4.534]
11. Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY (2019) Palmitic acid is an intracellular signaling molecule involved in disease development. Cellular and Molecular Life Science [Impact factor: 9.261]
12. Zhao L, Huang Y, Lu L, Yang W, Huang T, Lin Z, Lin CY, Kwan HY, Wong HLX, Chen Y, Sun S, Xie X, Fang X, Yang H, Wang J, Zhu L, Bian Z (2018) Saturated long-chain fatty acid-producing bacteria contributes to enhanced colonic motility in rats. Microbiome 2018;6(1):107. [Impact factor:14.65]
13. Wong HLX, Cao R, Chan KM, Jin G, Cao Y, Zhou Z (2012). When MT1-MMP Meets ADAMs. Cell Cycle, 11 [Impact factor: 4.534]
14. Wong HLX, Zhou Z (2012) The Functional Crosstalk between MT1-MMP and ADAMs (2012) Biochemistry & Analytical Biochemistry (invited editorial)
15. Jin G, Zhang F, Chan KM, Wong HLX, Liu B, Cheah KSE, Liu X, Mauch C, Liu D, Zhou Z (2011). MT1-MMP cleaves Dll1 to negatively regulate Notch signaling to maintain normal B-cell development. EMBO J., 30: 2281-2293 [5-year Impact factor: 12.9]