劉進博士教學科研部助理教授
liujin@hkbu.edu.hk

劉進博士分別於2010年在中山大學取得西醫臨床醫學學士學位，2013年在中山大學取得西醫臨床醫學碩士學位，2016年在香港浸會大學取得生物醫學博士學位。畢業後在香港浸會大學羅守輝骨與關節疾病轉化醫學研究所先後從事博士後研究工作和擔任研究助理教授，並於2021年晉升為香港浸會大學中醫藥學院助理教授。
劉博士的研究興趣集中在外泌體介導的細胞通訊機制調控肌肉骨骼系統發育與疾病的基礎與轉化研究。以第一作者/通訊作者在Nature Medicine, Nature Communications, Nature Aging, Biomaterials, Advanced Science, Aging Cell, EBioMedicine 等國際知名學術期刊發表多篇研究論文。
***誠摯邀請研究生，博士後研究員和研究助理加入我們的團隊。有關職位的查詢，請與劉博士聯繫(電子郵件：liujin@hkbu.edu.hk) 。
精選出版物Liu J^# (^#corresponding author), Wu X, Lu J, Huang G, Dang L, Zhang H, Zhong C, Zhang Z, Li D, Li F, Liang C, Yu Y, Zhang B-T, Chen L, Lu A#, Zhang G#. Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression. Nature Aging, 2021 1: 368-84. doi: 10.1038/s43587-021-00050-6.
Li D*, Liu J* (*co-first author), Yang C, Tian Y, Yin C, Hu L, Chen Z, Zhao F, Zhang R, Lu A, Zhang G, Qian A. Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging. Theranostics, 2021 11: 5585-604. doi: 10.7150/thno.54477
Dai R, Wu Z, Chu H Y, Lu J, Lyu A, Liu J^# (^#corresponding author), Zhang G#. Cathepsin K: The Action in and Beyond Bone. Front Cell Dev Biol, 2020 8: 433. doi: 10.3389/fcell.2020.00433.
Liu J, Dang L, Wu X, Li D, Ren Q, Lu A, Zhang G. microRNA-Mediated Regulation of Bone Remodeling: A Brief Review. JBMR Plus, 2019 Sep;3: e10213. doi: 10.1002/jbm4.10213.
He X*, Liu J* (*co-first author), Liang C, Badshah S A, Zheng K, Dang L, Guo B, Li D, Lu C, Guo Q, Fan D, Bian Y, Feng H, Xiao L, Pan X, Xiao C, Zhang B, Zhang G, Lu A. Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis. EBioMedicine, 2019 Mar;41: 538-55. doi: 10.1016/j.ebiom.2019.02.009.
Li F*, Lu J*, Liu J* (*co-first author), Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z K, Li J, Lv Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B T, Lu A, Zhang G. A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun, 2017 Nov 9;8: 1390. doi: 10.1038/s41467-017-01565-6.
Liu J, Li D, Wu X, Dang L, Lu A, Zhang G. Bone-derived exosomes. Curr Opin Pharmacol, 2017 Jun;34: 64-69. doi: 10.1016/j.coph.2017.08.008.
Liu J, Lu C, Wu X, Zhang Z, Li J, Guo B, Li D, Liang C, Dang L, Pan X, Peng S, Lu A, Zhang B, Zhang G. Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis. Sci Rep, 2017 Jan 27;7: 41295. doi: 10.1038/srep41295.
Liu J, Li D, Dang L, Liang C, Guo B, Lu C, He X, Cheung H Y, He B, Liu B, Li F, Lu J, Wang L, Shaikh A B, Jiang F, Lu C, Peng S, Zhang Z, Zhang B T, Pan X, Xiao L, Lu A, Zhang G. Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer. Sci Rep, 2017 Jan 10;7: 40487. doi: 10.1038/srep40487.
Liu J, Liang C, Guo B, Wu X, Li D, Zhang Z, Zheng K, Dang L, He X, Lu C, Peng S, Pan X, Zhang B T, Lu A, Zhang G. Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. Aging Cell, 2017 Apr;16: 360-76. doi: 10.1111/acel.12566.
Li D*, Liu J* (*co-first author), Guo B, Liang C, Dang L, Lu C, He X, Cheung H Y, Xu L, Lu C, He B, Liu B, Shaikh A B, Li F, Wang L, Yang Z, Au D W, Peng S, Zhang Z, Zhang B T, Pan X, Qian A, Shang P, Xiao L, Jiang B, Wong C K, Xu J, Bian Z, Liang Z, Guo D A, Zhu H, Tan W, Lu A, Zhang G. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun, 2016 Mar 7;7: 10872. doi: 10.1038/ncomms10872.
Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au D W, Chiang M W, Zhang B T, Han Q, Yue K K, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials, 2015 Jun;52: 148-60. doi: 10.1016/j.biomaterials.2015.02.007.
Fu M*, Liu J* (*co-first author), Huang G, Huang Z, Zhang Z, Wu P, Wang B, Yang Z, Liao W. Impaired ossification coupled with accelerated cartilage degeneration in developmental dysplasia of the hip: evidences from muCT arthrography in a rat model. BMC Musculoskelet Disord, 2014 Oct 8;15: 339. doi: 10.1186/1471-2474-15-339.