Professor CHAN Ho Yin Edwin
Address
(Office): Rm 509B, Mong Man Wai Building
(Lab): Rm 509A, Mong Man Wai Building

Phone
(Office): (852) 3943 4021
(Lab): (852) 3943 8032

Fax (852) 2603 7732

Email This email address is being protected from spambots. You need JavaScript enabled to view it.

Web i. http://www.bch.cuhk.edu.hk/LDR/LDR_news.html
ii. http://www.bch.cuhk.edu.hk/LDR/LDR_publication.aspiii.
iii. http://scholars.croucher.org.hk/scholars/chan-ho-yin-edwin

Education1999 Ph.D. University of Cambridge
1995 B.Sc. The Chinese University of Hong Kong
PositionsProfessor, School of Life Sciences
Associate Head, Chung Chi College
Director, Laboratory of Drosophila Research
Deputy Director, Natural Sciences Programme, Science Faculty
Associate Director, Biochemistry Programme
Warden, Postgraduate Halls
Research InterestsHuman disease modelling
Cellular, genetic and biochemical analyses of RNA and protein toxicity in neurological diseases
Therapeutic intervention of neurological diseases
Representative PublicationsPeng, S., Guo, P., Lin, X., An, Y., Sze, K.H., Lau, M.H.Y., Chen, Z.S., Wang, Q., Li, W., Sun, J.K., Ma, S.Y., Chan, T.F., Lau, K.F., Ngo, J.C.K., Kwan, K.M., Wong, C.H., Lam, S.L., Zimmerman, S.C., Tuccinardi, T., Zuo, Z., Au Yeung, H.Y., Chow, H.M. and Chan, H.Y.E.* (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. Proc. Natl. Acad. Sci. USA. 118(19) e2022940118
Chen, Z.S.,Huang, X., Talbot, K. and Chan, H.Y.E.* (2021) A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Cell Death Dis. 12(2):136
Zhang, Q., An, Y., Chen, Z.S., Koon, A.C., Lau, K.F., Ngo, J.C.* and Chan, H.Y.E.* (2019) A peptidylic inhibitor for neutralizing r(GGGGCC)exp-associated neurodegeneration in C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Mol. Ther. Nucleic Acids16, 172-185.
Hong, H., Koon, A.C., Chen, Z.S., Wei, Y., An, Y., Li, W., Lau, M.H.Y., Lau, K.F., Ngo, J.C.K., Wong, C.H., Au-Yeung, H.Y., Zimmerman, S.C., Chan, H.Y.E.* (2019) AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. J. Biol. Chem. 294, 2757-2770.
Koon, A.C., Chen, Z.S., Peng, S.H., Fung, J.M., Zhang, X., Lembke, K.M., Chow, H.K., Frank, C.A., Jiang, L.W., Lau, K.F. and Chan, H.Y.E.* (2018) Drosophila Exo70 is essential for neurite extension and survival under thermal stress. J. Neurosci. 38, 8071-8086.
Chen, Z.S., Li, L., Peng, S., Chen, F.M., Zhang, Q., An, Y., Lin, X., Li, W., Chan, T.F., Lau, K.F., Ngo, J.C., Wong, W.T., Kwan, K.M. and Chan, H.Y.E.* (2018) Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative diseases. EMBO Rep. 19, e45419
Li L., Ng, N.K. Koon, A.C., Chan, H.Y.E.* (2017) Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eukaryotic translation elongation factor 1 alpha 1. J. Biol. Chem. 292, 5784-5800.
Tsoi, H., Yu, A.C., Chen, Z.S., Ng, N.K., Chan, A.Y., Yuen, L.Y., Abrigo, J.M., Tsang, S.Y., Tsui, S.K., Tong, T.M., Lo, I.F., Lam, S.T., Mok, V.C, Wong, L.K., Ngo, C.K., Lau, K.F., Chan, T.F.* and Chan, H.Y.E.* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51, 590-595.
Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.* and Li, M.* (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8, 98-108.
Tsoi, H., Lau, C.K., Tsang, S.Y., Lau, K.F. and Chan, H.Y.E.* (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc. Natl. Acad. Sci. USA. 109, 13428-13433.
Research Grants2021-2022, Research Grants Council (RGC) GRF Grant, The role of adhesion molecule FasII/NCAM in synaptic dysfunction and neurodegeneration in myotonic dystrophy type I, $892,655
2020-2022, Research Grants Council (RGC) GRF Grant, How can we handle DNA damage induced by toxic RNAs?, $1,097,419
2019-2020, Research Grants Council (RGC) GRF Grant, Investigating the role of PAPD5 and its target microRNAs in RNA toxicity of polyglutamine diseases., $677,160
2016-2017, Research Grants Council (RGC) GRF Grant, Dissecting the regulatory mechanism of ubiquitin E3 ligase activity and understanding the importance of such regulation in polyglutamine pathogenesis., $768,202
2015-2019, The French National Research Agency (ANR)/Research Grants Council (RGC) Joint Research Scheme, Refining the bioactivity of P42, a hit therapeutic peptide, and developing a combined therapeutic peptide approach for treating Huntington’s Disease., $2,540,083
2015-2017, Research Grants Council (RGC) GRF Grant, Characterization of a novel pathogenic pathway of Huntington's Disease., $877,717
2014-2017, Research Grants Council (RGC) CRF Grant, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors., $7,044,220
2014-2016, Research Grants Council (RGC) GRF Grant, Characterization of a novel type of protein nuclear export signal in polyalanine expansion disease proteins., $866,032
2013-2015, Health and Medical Research Fund (HMRF) Grant, An inhibitory peptide approach to simultaneously target RNA and protein toxicities in polyglutamine degeneration., $999,908
2013-2015, Research Grants Council (RGC) GRF Grant, The role of nucleolin in CAG trinucleotide repeat-mediated RNA toxicity., $790,000
2009-2012, Research Grants Council (RGC) GRF Grant, Probing the nuclear transport role of the mutant polyglutamine domain in neurodegeneration., $929,247
2009-2011, Research Fund for the Control of Infectious Diseases Research (RFCID) Grant, Investigating the involvement of P13K/PDK-1/Akt pathways and Notch signals in SARS-CoV Membrane-induced apoptosis., $741,448
2009-2010, Cure Huntington’s Disease Initiative Foundation Early Discovery Initiative Fund, USA, Using the 3B5H10 Monoclonal Antibody to Investigate Huntingtin Oligomer and Toxicity in vivo., $444,149
2004-2007, Research Grants Council (RGC) Earmarked Grant, Nucleocytoplasmic transport and polyglutamine toxicity: A cellular genetic study., $1,265,677
2004-2006, Research Fund for the Control of Infectious Diseases Research (RFCID) Grant, Molecular and Genetic Characterization of the SARS Coronavirus Auxiliary Protein X1 in Drosophila., $675,144
2003-2007, Research Grants Council (RGC) Earmarked Grant, Genetic and proteomic studies of chaperone-mediated suppression of polyglutamine toxicity in Drosophila., $1,203,000
PatentsChan, H. Y. E.; Ngo, J. C.; Wong, C.; Zhang, Q.; Peng, S. Small molecule inhibitors targeting CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent US 10,143,666, Dec 4, 2018
Chan, H.Y.E.; Ngo, J.C.; Zhang, Q. Peptidylic inhibitors targeting C9ORF72 hexanucleotide repeat-mediated neurodegeneration. U.S. Patent US-2-A1, August 2, 2018
Chan, H.Y.E.; Ngo, J.C.; Zhang, Q. Peptidylic inhibitor targeting CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent US-2-A1, August 17, 2017
Chan, H.Y.E.; Jensen, K.J.; Ngo, J.C.; Sorensen, K.K.; Zhang, Q.; Zuo, Z. P3 Peptidylic inhibitors for treating CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent 62/465,513, March 10, 2017
Chan, H. Y. E.; Tsoi, H.; Ngo, J. C.; Lau, K. F. Therapeutic approach for polyglutamine degeneration. U.S. Patent US 9,297,798, March 29, 2016
Awards2014 Churchill College Visiting By-Fellowship, University of Cambridge, UK
2011 Genetics Society of China Thirteenth Ju-Chi Li Animal Genetics Prize (第十三届李汝祺动物遗传学奖)
The 2009 Young Researcher Award, The Chinese University of Hong Kong
The 2009 Faculty Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong
Professional ActivitiesAssociate Editor, Frontiers in Neurodegeneration
Founding member, The Hong Kong Young Academy of Sciences
Member, Executive Committee, The Hong Kong Young Academy of Sciences
Topic Editor, Frontiers in Cellular Neuroscience
Editoral Board, Advances in Alzheimer's Disease
Editoral Board, RNA & DISEASE
Visiting Professor, Central South University
Member, Asia-Pacific Drosophila Board
Member, Scientific Advisory Committee, Society for Research on the Cerebellum
OthersMember, Charter of the Ataxia Global Initiative working group, Ataxia Global Initiative
Member, Medical Advisory Board, Advancing CTNNB1 Cures and Treatments Inc.
Member, Academic Committee of Asia Pacific Drosophila Neuroscience Conference, Academia Sinica, Taiwan, 2019
Organizer, Inaugural Asia-Pacific Drosophila Neurobiology Conference, Wuhan, China, 2017
Session Chair (Drosophila models for human diseases), 2nd Asia-Pacific Drosophila Research Conference, Seoul, Korea, 2013
Chairperson, Scientific and Medical Advisory Committee, Hong Kong Spinocerebellar Ataxia Association, 2012 – present

Current Academic/Research Positions of Lab AlumniProfessor Choi Jonathan, Associate Professor, Department of Biomedical Engineering, CUHK
Professor Wong Siu Lun Alan, Assistant Professor, School of Biomedical Sciences, HKU
Dr. Chan Priscilla, Associate Director of Research & Development, Nano and Advanced Materials Institute Limited, HK
Dr. Chan Kam Leung, Lecturer, School of Chinese Medicine, CUHK
Dr. Koon Alex Chun, Lecturer, School of Biomedical Sciences, HKU
Dr. Cheng Tat Cheung, CryoEM scientist, University of Gottingen, Germany
Dr. An Ying, Postdoc Fellow, CUHK
Dr. Chen Stephen, Postdoc Fellow, University of Oxford, UK
Dr. Choi Ching Gee, Postdoc Fellow, HKU
Dr. Law Carman, Postdoc Fellow, City University of Hong Kong
Dr. Li Li, Postdoc Fellow, College of Physics Science and Technology, Shenzhen University
Dr. Ng Nelson, Postdoc Fellow, HKU
Dr. Peng Isaac, Postdoc Fellow, CUHK
Dr. Zhang Qian, Postdoc Fellow, German Research Center for Environmental Health, Institute of Diabetes and Obesity, Germany
Dr. Wu Chi Chung, Postdoc Fellow, Max Planck Institute for Heart and Lung Research, Germany