Professor CHAN Michael Kenneth
Address
(Office): Room 603B, Mong Man Wai Building
(Lab): Room 611, Mong Man Wai Building

Phone
(Office): (852) 3943 1487
(Lab): (852) 3943 6162

Fax
(852) 2603 5646

Email
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Web
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EducationB.S. (Chemistry) Harvey Mudd College, Claremont, CA
Ph.D. (Chemistry) University of California, Berkeley, CA
Postdoctoral Fellow (Protein Crystallography) California Institute of Technology, Pasadena, CA
Positions1995-2001 Assistant Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
2001-2005 Associate Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
2005-2012 Professor of Chemistry/Biochemistry, The Ohio State University, Columbus, OH
2010-2012 Interim-Chair of Biochemistry, The Ohio State University, Columbus, OH
2012-2015 Director, School of Life Sciences, The Chinese University of Hong Kong
2012- Present Professor, School of Life Sciences, The Chinese University of Hong Kong
Research InterestsChemical Biology - We are working to capitalize on our discovery of pyrrolysine, the 22^nd genetically-encoded amino acid, to engineer proteins with novel structures and properties.
Protein crystallography - We wish to use protein crystallography to elucidate the structure function relationships of proteins.
Protein Delivery - We are exploring new technologies to deliver proteins to cells.

Representative Publications
Yang, Z.; Yang, M.; Chow, H.-M.; Tsang, S.Y.; Lee, M.M.; Chan; M.K. “Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy”, Acta Biomater. 2021, 135, 582-592. doi.org/10.1016/j.actbio.2021.08.054
Yang, Z.; Lee, M.M.; Chan; M.K. “Efficient intracellular delivery of p53 protein by engineered protein crystals restores tumor suppressing function in vivo”, Biomaterials, 2021,271:120759. doi.org/10.1016/j.biomaterials.2021.120759.
Liang, Z.; Chan, H.Y.E.; Lee, M.M.; Chan, M.K. "A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation
Cry protein crystals: a novel platform for protein delivery" PLoS One, 2015, 10, 1-16.
Li, X.*; Fekner, T.*; Ottesen, J.J.; Chan, M.K., “A pyrrolysine analog for site-specific protein ubiquitination”,Angew. Chem., 2009, 48, 9184-7.
Fekner, T.; Li, X.; Lee, M.M.; Chan, M.K., “A pyrrolysine analog for protein click chemistry” Angew. Chem., 2009, 48, 1633-5.
Gong, W.*; Hao, B.*; Wei, Z.; Ferguson, D.J. Jr.; Tallant, T.; Krzycki, J.A.; Chan, M.K., “Structure of the CODH component of theM. barkeriACDS complex”Proc. Natl. Acad. Sci. USA2008, 105, 9558-63.
Blight, S.K.; Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E. Zhao, G., Kang, P., Green-Church, K.B., Chan, M.K., Krzycki, J.A., “Direct charging of tRNA^CUA with pyrrolysinein vitroandin vivo”Nature, 2004, 431, 333-5. (cited inNature, C&E News)
Hao, B., Gong, W., Ferguson, T.K., James, C.M., Krzycki, J.A., Chan, M.K., “Identification of novel UAG encoded residue: structure of a methanogen methyltransferase”Science, 2002, 296, 1462-1466. (cited inC&E News,Nature, Science,CNN Headline News, Reuters)
Gong, W.* Hao, B., Mansy, S.S., Gonzalez, G. Gilles-Gonzalez, M.A., Chan, M.K., “Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction”Proc. Natl. Acad. Sci. USA, 1998, 95, 15177-15182.
Research Grants
2022-2024, Research Grants Council GRF, “Engineered Cry3Aa crystals for improved antimicrobial peptide delivery against intramacrophage infections”
2021-2024, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "Bioengineering arginine decarboxylase as a new therapeutic for cancer treatment”
2021-2023, Innovation and Technology Fund, “SUMO-derived peptide inhibitors for treating synucleinopathies”
2021-2022, Innovation and Technology Fund, (Co-I, PI: Y.P. Ho) “Development of a micro shear porator for loading red blood cells with therapeutic proteins”
2020-2022 Research Grants Council GRF, “Structural Studies of pyrrolysine-containing Methyltransferases”
2020-2021, Innovation and Technology Fund, “A versatile platform for generating recyclable catalysts for the production of biodiesel and commodity chemicals”
2019-2022, Research Grants Council GRF, “Genetically-encoded immobilized lipases for biofuel production”
2018-2021, Research Grants Council GRF, “Structural studies of nematicidal Cry proteins”
2017-2026, Research Grants Council AOE Grant (Co-PI, PI: Yang), “Chemical biology approach to molecular medicine”
2017-2019, Research Grants Council GRF, "Immobilized lipases for biodiesel conversion"
2016-2018, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "A novel anti-microbial crystal for the treatment ofHelicobacter pyloriinfection"
2016-2019, Research Grants Council GRF, "Exploring the potential of myoglobin as an anti-cancer agent"
2015-2017, Health and Medical Research Fund, "Biological crystal subunit vaccines for mycobacterial diseases"
2015-2018, Research Grants Council GRF, “Studies of a copper peptide complex that can mediate methane oxidation”
2013-2015, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 10: “Novel dawadawa therapy for intestinal helminthic infections”
2012-2014, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 9: “A new system for dual bacterial/insecticidal crop protection”
Awards
Lando-SOHIO Fellowship, University of Minnesota (1984), Sigma Xi (1986), Phi-Lambda Upsilon (1986), Regents Fellowship, University of California (1986), Amoco Foundation Fellowship in Chemistry (1991), NIH Postdoctoral Fellowship (1992-1994), NSF Career Award (2000), Alfred P. Sloan Fellowship (2000), Member, NIH Study Section-BMT (2002-2006), Mr. and Mrs. Sun Chan Award in Organic Chemistry (2002), Visiting Scholar of the National Research Council of the Republic of China (2002), OSU College of Biological Sciences Award for Research and Graduate Education (2004), Visiting Scholar of the National Research Council of the Republic of China (2005, 2011), Japan Society for Promotion of Science Fellowship (2006), OSU Distinguished Scholar Award (2009), S. Y. Chung Visiting Fellow of New Asia College, CUHK (2010), Fellow of the American Association for the Advancement of Science (2011), Cynthia Anne Chan Memorial Lecturer, UC Berkeley (2011), RGC Physical Science Panel (2011, Chair 2012).
OthersWe currently have openings starting on Nov 1, Feb 1, and May 1 for either a research assistant or postdoc having a degree from either a Hong Kong or Top 100 University. Those interested should contact us 3 months before the target start date.
We are also currently recruiting highly motivated graduate students with prior publications and/or exceptional academic records who are competitive for the Hong Kong Postgraduate fellowship Scheme. Please contact us by Nov 1 for consideration.