Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陶谦教授 (肿瘤学系) |
| 李力力教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s00705-012-1481-x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/8WOS source URL
其它资讯
摘要Epstein-Barr virus (EBV) is responsible for the development of multiple tumors, including EBV-associated gastric carcinoma (EBVaGC), but little is known about its mechanisms in EBVaGC. WNT5A expression and promoter methylation were measured in 5 EBV-positive and 15 EBV-negative GC cell lines. The methylation status of 23 EBV-positive and 25 EBV-negative paired tumor/normal tissue samples was also examined. EBV-positive GC had no or very low expression of WNT5A but a high level of methylation in the promoter region. In contrast, EBV-negative GC had higher WNT5A expression and a lower level of promoter methylation. The reduced WNT5A expression could be restored by treatment with Aza, a methyltransferase inhibitor. Increased expression of WNT5A in vitro inhibited beta-catentin expression in EBVaGC cells (SNU719). These results suggest that hypermethylation of WNT5A induced by EBV may contribute to the development of EBVaGC. Ectopic introduction of WNT5A may have preventive/therapeutic potential for tumors with silenced WNT5A.
着者Liu X, Wang Y, Wang XF, Sun ZF, Li LL, Tao Q, Luo B
期刊名称Archives of Virology
出版年份2013
月份1
日期1
卷号15http://aims.cuhk.edu.hk/converis/portal/Publication/8
期次1
出版社SPRINGER WIEN
页次123 - 132
国际标準期刊号0304-http://aims.cuhk.edu.hk/converis/portal/Publication/860http://aims.cuhk.edu.hk/converis/portal/Publication/8
语言英式英语
Web of Science 学科类别Virology; VIROLOGY
