Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈德章教授 (肿瘤学系) |
| 洪波博士 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/hed.21877 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
其它资讯
摘要Background Nasopharyngeal carcinoma (NPC) is an endemic head and neck cancer in Southeast Asia. Although concurrent chemoradiotherapy generally results in good clinical response for early diseases, posttreatment relapse and distant metastasis are major causes for NPC deaths. There is an urgent need for more effective therapies for advanced NPC. Recent studies have demonstrated tumor hypoxia can be a therapeutic target in NPC. Methods A Medline review of articles published on clinical and preclinical studies targeting tumor hypoxia was performed. Results Studies published to date showed that tumor hypoxia is common in NPC and it is associated with disease progression and resistance to therapy. Several mechanisms have been proposed on the role of tumor hypoxia in NPC cell survival, angiogenesis, and metabolism. Studies reported by us and by others have demonstrated the therapeutic potential of targeting tumor hypoxia in NPC. Conclusions Cumulative studies indicate that targeting tumor hypoxia could be an effective approach for NPC treatment. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2013
着者Hong B, Lui VWY, Hashiguchi M, Hui EP, Chan ATC
期刊名称HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
详细描述To ORKTS: URL fm RAO.
出版年份2013
月份1
日期1
卷号35
期次1
出版社WILEY-BLACKWELL
页次133 - 145
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1043-3074
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1097-0347
语言英式英语
关键词HIF-1 alpha; hypoxia; mechanism for carcinogenesis; nasopharyngeal cancer (NPC); targeted therapy
Web of Science 学科类别Otorhinolaryngology; OTORHINOLARYNGOLOGY; Surgery; SURGERY
