Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李力力教授 (肿瘤学系) |
| 陶谦教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.5732/cjc.011.10381 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/13Scopus source URL
其它资讯
摘要Esophageal squamous cell carcinoma (ESCC) is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes (TSGs) is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.
着者Li J.-S., Ying J.-M., Wang X.-W., Wang Z.-H., Tao Q., Li L.-L.
期刊名称Chinese Journal of Cancer
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/13
月份1
日期17
卷号32
期次1
出版社Landes Bioscience
出版地United States
页次3 - 11
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1000-467X
电子国际标準期刊号1944-446X
语言英式英语
关键词CpG island, Esophageal squamous cell carcinoma, Promoter methylation, Tumor marker, Tumor suppressor gene
