Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李国章教授 (外科学系) |
| 刘允怡教授 (外科学系) |
| 梁惠棠教授 (肿瘤学系) |
| 梁慧仪教授 |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.jhep.2011.09.013 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/69Scopus source URL
其它资讯
摘要Background & Aims: In animal studies, expression of hepatitis B virus (HBV) proteins causes hepatic steatosis. We aimed to study the prevalence of fatty liver in people with and without HBV infection in the general population. Methods: We performed a cross-sectional population study in Hong Kong Chinese. Intrahepatic triglyceride content (IHTG) was measured by proton-magnetic resonance spectroscopy. Results: One thousand and thirteen subjects (91 HBV patients and 922 controls) were recruited. The median IHTG was 1.3% (0.2-33.3) in HBV patients and 2.1% (0-44.2) in controls (p <0.001). Excluding subjects with significant alcohol consumption, the prevalence of nonalcoholic fatty liver disease was 13.5% (95% confidence interval [CI] 6.4%, 20.6%) in HBV patients and 28.3% (95% CI 25.3%, 31.2%) in controls (p = 0.003). The fatty liver prevalence differed in HBV patients and controls aged 40-59 years but was similar in those aged 60 years or above. After adjusting for demographic and metabolic factors, HBV infection remained an independent factor associated with lower risk of fatty liver (adjusted odds ratio 0.42; 95% CI 0.20, 0.88; p = 0.022). HBV patients also had a lower prevalence of metabolic syndrome (11.0% vs. 20.2%; p = 0.034), but the difference was mainly attributed to lower triglyceride levels. Among HBV patients, viral genotypes, HBV DNA level and hepatitis B e antigen status were not associated with fatty liver. Conclusions: HBV infection is associated with a lower prevalence of fatty liver, hypertriglyceridemia and metabolic syndrome. Viral replication may affect lipid metabolism and this warrants further studies. ? 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
着者Wong V.W.-S., Wong G.L.-H., Chu W.C.-W., Chim A.M.-L., Ong A., Yeung D.K.-W., Yiu K.K.-L., Chu S.H.-T., Chan H.-Y., Woo J., Chan F.K.-L., Chan H.L.-Y.
期刊名称Journal of Hepatology
详细描述Paper presented in the Advances in Liver Cancer and Hepatitis Research
出版年份2012
月份3
日期1
卷号56
期次3
出版社Elsevier BV
出版地Netherlands
页次533 - 540
国际标準期刊号0168-8278
电子国际标準期刊号1600-0641
语言英式英语
关键词Cross-sectional study, Diabetes mellitus, Hypertriglyceridemia, Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis, Obesity
