Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陶谦教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1039/c1nr10499c |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/57WOS source URL
其它资讯
摘要A systematic study on the interaction of silica nanoparticles (NPs) with human cells has been carried out in the present work. Endocytosis and exocytosis are identified as major pathways for NPs entering, and exiting the cells, respectively. Most of the NPs are found to be enclosed in membrane bounded organelles, which are fairly stable (against rupture) as very few NPs are released into the cytoplasm. The nanoparticle-cell interaction is a dynamic process, and the amount of NPs inside the cells is affected by both the amount and morphology (degree of aggregation) of NPs in the medium. These interaction characteristics determine the low cytotoxicity of SiO(2) NPs at low feeding concentration.
着者Chu ZQ, Huang YJ, Tao Q, Li Q
期刊名称Nanoscale
出版年份2011
月份1
日期1
卷号3
期次8
出版社Royal Society of Chemistry
页次3291 - 3299
国际标準期刊号2040-3364
电子国际标準期刊号2040-3372
语言英式英语
Web of Science 学科类别Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Materials Science; Materials Science, Multidisciplinary; MATERIALS SCIENCE, MULTIDISCIPLINARY; Nanoscience & Nanotechnology; NANOSCIENCE & NANOTECHNOLOGY; Physics; Physics, Applied; PHYSICS, APPLIED; Science & Technology - Other Topics
