Epigenetic disruption of cell signaling in nasopharyngeal carcinoma
Publication in refereed journal


香港中文大学研究人员 ( 现职)

陶谦教授 (肿瘤学系)

李力力教授 (肿瘤学系)

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摘要Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia. Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/ or histone modifications. These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC. In this review, we summarize the epigenetic deregulation of cell signaling in NPC tumorigenesis and highlight the importance of identifying epigenetic cell signaling regulators in NPC research. Developing pharmacologie strategies to reverse the epigenetic-silencing of cell signaling regulators might thus be useful to NPC prevention and therapy.

着者Li L.-L., Shu X.-S., Wang Z.-H., Cao Y., Tao Q.
期刊名称Chinese Journal of Cancer
出版年份2011
月份4
日期20
卷号30
期次4
出版社Landes Bioscience
出版地United States
页次http://aims.cuhk.edu.hk/converis/portal/Publication/231 - http://aims.cuhk.edu.hk/converis/portal/Publication/239
国际标準期刊号1000-467X
电子国际标準期刊号1944-446X
语言英式英语

关键词Cell signaling, Epigenetic, Nasopharyngeal neoplasm