Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 许陈小章教授 (生物医学学院) |
| 张小虎博士 (生物医学学院) |
| 陶谦教授 (肿瘤学系) |
| 陈扬超教授 (生物医学学院) |
| 陈浩博士 (生物医学学院) |
| 蒋?华教授 (生物医学学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/carcin/bgs246 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
其它资讯
摘要The expression of serine/threonine kinase (STK) family is frequently altered in human cancers. However, the functions of these kinases in cancer development remain elusive. Here, we report that STK31 is robustly and heterogeneously expressed in colon cancer tissues and plays a critical role in determining the differentiation state of colon cancer cells. Knockdown or overexpression of STK31 induced or inhibited differentiation of colon cancer cells, respectively. Deletion of the STK domain abolished the inhibiting effect of STK31. Associated with differentiation, knockdown of STK31 resulted in significant suppression of tumorigenicity both in vitro and in vivo. Genome microarray analysis showed that knockdown of STK31 altered the expression profile of genes that are known to be involved in germ cell and cancer differentiation. Taken together, these results suggest that STK31 is able to control the differentiation state of colon cancer cells, which critically depends on its STK domain. The present findings may shed light on the new therapeutic approach against cancer by targeting STK31 and cancer differentiation.
着者Fok KL, Chung CM, Yi SQ, Jiang XH, Sun X, Chen H, Chen YC, Kung HF, Tao Q, Diao RY, Chan H, Zhang XH, Chung YW, Cai ZM, Chan HC
期刊名称Carcinogenesis
详细描述To ORKTS: doi:http://aims.cuhk.edu.hk/converis/portal/Publication/10.http://aims.cuhk.edu.hk/converis/portal/Publication/1093/carcin/bgs246
出版年份2012
月份11
日期1
卷号33
期次11
出版社Oxford University Press (OUP): Policy B - Oxford Open Option B
页次2044 - 2053
国际标準期刊号0143-3334
电子国际标準期刊号1460-2180
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
