Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 庄立信教授 (肿瘤学系) |
| 杨明明教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S1386-6532(00)00066-4 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/46WOS source URL
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摘要Background: TT virus (TTV) is a recently discovered virus, which is not related to any other known virus infecting humans. Objectives: To investigate: (i) the world-wide distribution of the three major TTV genotypes; and (ii) the possible routes of viral transmission. Study design: (i) The phylogenetic distribution of 494 TTV isolates originating from 31 countries was analysed, using partial ORF1 sequences. (ii) Faeces samples (n = 22) and saliva samples (n = 72) from French individuals were tested for the presence of TTV DNA. (iii) Viral titres in paired serum and saliva samples were compared. Results: (i) Genotypes 1, 2 and 3 were distributed world-wide, with a high proportion of type 1 in Asia (71%) and no type 3 identified in Africa to date. In the USA, 77% of isolates were grouped in four clusters only (genetic distances < 10%). This was also the case of 76% of French isolates, 76% of Japanese isolates, and 89% of Hong Kong isolates. (ii) TTV DNA was detected in 18% of faeces samples and 68% of saliva samples tested. (iii) Viral titre in saliva samples was 100-1000 times higher than that of the corresponding serum. Conclusions: (i) The observed epidemiological distribution of TTV isolates is compatible with an ancient dissemination of viral ancestors belonging to the different genotypes and a slow genetic evolution in sedentary populations. (ii) Besides the possible transmission of TTV by the parental and oral-faecal routes, the high titre of TTV DNA observed in saliva raises the hypothesis of the viral transmission by saliva droplets. This route of transmission could explain the high degree of exposure to viral infection observed in the general population. (C) 2000 Elsevier Science B.V. All rights reserved.
着者Gallian P, Biagini P, Zhong S, Touinssi M, Yeo W, Cantaloube JF, Attoui H, de Micco P, Johnson PJ, de Lamballerie X
期刊名称Journal of Clinical Virology
出版年份2000
月份6
日期1
卷号17
期次1
出版社ELSEVIER SCIENCE BV
页次43 - 49
国际标準期刊号1386-6532
语言英式英语
关键词ORF1 sequences; TT virus; TTV DNA
Web of Science 学科类别Virology; VIROLOGY
