Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 刘允怡教授 (外科学系) |
| 梁惠棠教授 (肿瘤学系) |
| 庄立信教授 (肿瘤学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
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摘要This short review summarizes an integrated approach to new methods of managing hepatocellular carcinoma (HCC) developed at our centre. HCC-specific isoforms of alpha-fetoprotein were detected by isoelectric focusing and their value in the differential diagnosis of early HCC on a background of chronic liver disease has been shown. Selective internal radiation therapy using yttrium-90 (Y-90) microspheres has been shown to be an effective treatment for inoperable HCC in a phase I and II study. A partition model for estimating the radiation doses from the Y-90 microspheres to the tumour and the non-tumorous liver during the therapy was then formulated, verified by correlating with intraoperative dosimetry, and evaluated in clinical settings. This permits Y-90 microspheres to be administered safely without the need of an open surgery and a randomized therapeutic controlled trial is in progress. Another radomized controlled trial using iodine-1http://aims.cuhk.edu.hk/converis/portal/Publication/31 Lipiodol as a post-operative adjuvant therapy, aiming at reducing the recurrence rate is also on-going. HCC may be more effectively combated with a better understanding of its pathogenesis from chronic liver disease.
着者Ho S, Johnson PJ, Leung WT, Lau WY
期刊名称CHINESE MEDICAL JOURNAL
出版年份1999
月份1
日期1
卷号112
期次1
出版社CHINESE MEDICAL ASSOCIATION
页次80 - 8http://aims.cuhk.edu.hk/converis/portal/Publication/3
国际标準期刊号0http://aims.cuhk.edu.hk/converis/portal/Publication/366-6999
语言英式英语
关键词hepatocellular carcinoma; integrated approach
Web of Science 学科类别General & Internal Medicine; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL
