Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林革教授 (生物医学学院) |
| 杜健华教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1186/1749-8546-5-26 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/28Scopus source URL
其它资讯
摘要Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.? 2010 Chai et al; licensee BioMed Central Ltd.
着者Chai S., To K.K.W., Lin G.
期刊名称Chinese Medicine
出版年份2010
月份7
日期25
卷号5
出版社BioMed Central
出版地United Kingdom
国际标準期刊号1749-8546
语言英式英语
