Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 左中教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s11095-010-0127-5 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要Intranasal route continues to be one of the main focuses of drug delivery research. Although it is generally perceived that the nasal route could avoid the first-pass metabolism in liver and gastrointestinal tract, the role of metabolic conversions in systemic and brain-targeted deliveries of the parent compounds and their metabolites should not be underestimated. In this commentary, metabolite formations after intranasal and other routes of administration are compared. Also, the disposition of metabolites in plasma and brain after nasal administrations of parent drugs, prodrugs and preformed metabolites will be discussed. The importance and implications of metabolism for future nasal drug development are highlighted.
着者Wong YC, Zuo Z
期刊名称PHARMACEUTICAL RESEARCH
出版年份2010
月份7
日期1
卷号27
期次7
出版社SPRINGER/PLENUM PUBLISHERS
页次1208 - 1223
国际标準期刊号0724-8741
电子国际标準期刊号1573-904X
语言英式英语
关键词active metabolite; brain distribution; central nervous system; drug delivery; intranasal; metabolism
Web of Science 学科类别Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
