Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 汤宁信教授 |
| 胡淼教授 (内科及药物治疗学系) |
| 汤宁信教授 |
| 李国铭教授 |
| 谭丽珊教授 (内科及药物治疗学系) |
| 包立怡教授 (药剂学院) |
| 李咏恩教授 (药剂学院) |
| 朱天华博士 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1097/FPC.0b013e32833de489 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/25WOS source URL
其它资讯
摘要Lipid changes with statin treatments vary greatly between individuals for reasons which are largely unknown. This study was performed to examine the genetic determinants of lipid responses to rosuvastatin in Chinese patients. A total of 1http://aims.cuhk.edu.hk/converis/portal/Publication/25 polymorphisms in 61 candidate genes from 386 Chinese patients were analyzed for association with the lipid responses to rosuvastatin 10mg daily. The polymorphisms most highly associated with the low-density lipoprotein cholesterol (LDL-C) response were 421C>A in the ATP-binding cassette G2 gene (P=9.2 x 10(-7)), followed by 18281G>A (Vhttp://aims.cuhk.edu.hk/converis/portal/Publication/257M) in the flavin-containing monooxygenase 3 gene (P=0.0002), 1421C>G in the lipoprotein lipase gene (P=0.002), and rs4420638 in the apolipoprotein E/C-I/C-IV/C-II gene cluster (P=0.004). Patients with familial hypercholesterolemia had 2.6% smaller reductions in LDL-C compared with patients without familial hypercholesterolemia. This study identified some genetic determinants of LDL-C response to rosuvastatin in Chinese patients, which need to be replicated in other populations. Pharmacogenetics and Genomics 20:634-637 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
着者Hu MA, Lui SSH, Mak VWL, Chu TTW, Lee VWY, Poon EWM, Tsui TKC, Ko GTC, Baum L, Tam LS, Li EK, Tomlinson B
期刊名称Pharmacogenetics and Genomics
出版年份2010
月份10
日期1
卷号20
期次10
出版社Lippincott, Williams & Wilkins
页次634 - 637
国际标準期刊号1744-6872
电子国际标準期刊号1744-6880
语言英式英语
关键词Chinese; lipid responses; pharmacogenetics; rosuvastatin; single nucleotide polymorphisms
Web of Science 学科类别Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Genetics & Heredity; GENETICS & HEREDITY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
