Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 左中教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.ijpharm.2009.06.016 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/26WOS source URL
其它资讯
摘要The current study aims to investigate the effect of sodium caprate on the intestinal absorption and bioavailabilities of danshensu and salvianolic acid B, the major active components in Salvia miltiorrhiza Bge (Danshen). Biopharmaceutics and pharmacokinetics properties of the two compounds have been characterized by in vitro, in situ models as well as in vivo in rats. Based on the identified biopharmaceutics characteristics of the two compounds, effect of sodium carparate as absorption enhancer on the intestinal absorption and pharmacokinetics of danshensu and salvianolic acid B in pure compound form as well as extract form were investigated both in vitro and in vivo. Both clanshensu and salvianolic acid B demonstrated very limited intestinal permeabilities, leading to oral bioavailabilities of only 11.09% and 3.90% in rats, respectively. Results from both in vitro and in vivo studies consistently indicated that sodium caprate could significantly enhance intestinal permeabilities as well as the in vivo bioavailabilities of both clanshensu and salvianolic acid B. The current findings not only identified the usefulness of sodium caprate for the improved delivery of Danshen product but also demonstrated the importance of biopharmaceutics characterization in the dosage form development of traditional Chinese medicine. (C) 2009 Elsevier B.V. All rights reserved.
着者Zhou LM, Chow MSS, Zuo Z
期刊名称International Journal of Pharmaceutics
出版年份2009
月份9
日期8
卷号379
期次1
出版社Elsevier
页次109 - 118
国际标準期刊号0378-5173
电子国际标準期刊号1873-3476
语言英式英语
关键词Absorption enhancer; Bioavailability; Danshensu; Intestinal absorption; Salvianolic acid B; Sodium caprate
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
