Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李国铭教授 |
| 李?前教授 (药剂学院) |
| 李咏恩教授 (药剂学院) |
| 谭丽珊教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/art.24725 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/40WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/47Scopus source URL
其它资讯
摘要Objective. To evaluate both direct and indirect costs of systemic lupus erythematosus (SLE) patients with and without flares from a societal perspective, and to investigate the impact of the severity and clinical manifestations of flares on direct/indirect costs. Methods. A retrospective cost-of-illness study was performed on 306 SLE patients. Participants completed questionnaires on sociodemographics, employment status, and out-of-pocket expenses. Health resources consumption was recorded by chart review and patient self-reported questionnaire. The total number of flares and involved organs during the preceding 12 months were recorded. Multiple linear regression was performed to determine the cost predictors. Results. Patients with flares were younger, had shorter disease duration, and had higher disease activity at the time of the assessment. The overall incidence of lupus flares was 0.24 episodes per patient-year. Patients with flares used more health care resources and incurred significantly higher annual direct and indirect costs. The mean total costs per patient-year were 2-fold higher for patients with flares ($22,580 versus $10,870 [2006 US dollars]; P < 0.0005). Multiple regression analysis showed that the number of flares was an independent explanatory variable associated with increased direct costs. Patients with multiorgan flares or renal/neuropsychiatric flares incurred higher direct costs compared with those with single-organ flares or with other organ flares. Conclusion. Patients with flares incur higher direct and indirect costs compared with those without flares. Major organ flares incur higher disease costs than other organ flares. Treatments that effectively control disease activity and prevent flares, especially major organ flares, may reduce the high costs associated with flare in SLE. ? 2009, American College of Rheumatology.
着者Zhu T.Y., Tam L.-S., Lee V.W.-Y., Lee K.K.-C., Li E.K.
出版年份2009
月份9
日期15
卷号61
期次9
出版社John Wiley & Sons Inc.
出版地United States
页次1159 - 1167
国际标準期刊号2151-4658
语言英式英语
