Higher islet amyloid load in men than in women with type 2 diabetes mellitus.
Publication in refereed journal


香港中文大学研究人员 ( 现职)

汤宁信教授

唐俊业教授 (内科及药物治疗学系)

包立怡教授 (药剂学院)

隋昳博士 (内科及药物治疗学系)

赵海潞博士 (内科及药物治疗学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1097/MPA.0b013e3181788e18

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/6Scopus source URL

其它资讯

摘要OBJECTIVES: Type 2 diabetes mellitus is characterized histopathologically by islet amyloid deposits formed from islet amyloid polypeptide. The aim of this study was to investigate sex difference in islet amyloid of type 2 diabetic patients. METHODS: Pancreas specimens were collected from 2http://aims.cuhk.edu.hk/converis/portal/Publication/35 autopsies with type 2 diabetes mellitus. Islet amyloid was identified with Congo red stain. The load of islet amyloid deposits was assessed by prevalence (percentage of cases with islet amyloid deposits), frequency (percentage of islets containing amyloid deposits), and severity (percentage of islet area occupied by amyloid deposits). RESULTS: Women (n = 80) and men (n = 155) had similar age of death, duration of diabetes, body mass index, and hemoglobin (Hb)A1c level. Islet amyloid was found in http://aims.cuhk.edu.hk/converis/portal/Publication/30.0% of the women and in 44.5% of the men (P = 0.0http://aims.cuhk.edu.hk/converis/portal/Publication/35). None of 9 women younger than 50 years had islet amyloid. Frequency of amyloid-affected islets was http://aims.cuhk.edu.hk/converis/portal/Publication/31.5% +/- 1http://aims.cuhk.edu.hk/converis/portal/Publication/3.1% in women and 41.1% +/- 14.http://aims.cuhk.edu.hk/converis/portal/Publication/3% in men (P = 0.008). Severity of amyloid-affected islet area was 29.0% +/- 12.5% in women and http://aims.cuhk.edu.hk/converis/portal/Publication/38.5% +/- 14.http://aims.cuhk.edu.hk/converis/portal/Publication/6% in men (P = 0.007). CONCLUSIONS: Sex is a determinant of the development of islet amyloid in type 2 diabetes mellitus. This sex difference in islet amyloid may be related to a potential benefit of female sex hormones.

着者Zhao H.L., Sui Y., Guan J., He L., Lai F.M., Zhong D.R., Yang D., Baum L., Tong P.C., Tomlinson B., Chan J.C.
期刊名称Pancreas
出版年份2008
月份10
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/37
期次http://aims.cuhk.edu.hk/converis/portal/Publication/3
出版社Lippincott Williams & Wilkins Ltd.
出版地United States
国际标準期刊号0885-http://aims.cuhk.edu.hk/converis/portal/Publication/3177
语言英式英语