Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈家亮教授 (内科及药物治疗学系) |
| 李咏恩教授 (药剂学院) |
| 李菁菁女士 (微生物学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000112416 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/30WOS source URL
其它资讯
摘要Background: Fluoroquinolone-resistant Helicobacter pylori emerged in 1995 and the resistance was due to point mutation in the gyrA gene. In this study we investigate the resistance mechanism and the antimicrobial susceptibilities of clarithromycin, metronidazole, amoxicillin, tetracycline and telithromycin against levofloxacin-resistant H. pylori in Hong Kong. Methods: One hundred and ninety-one nonduplicate H. pylori isolates were collected during 2004 and 2005, and 25 isolates with levofloxacin zone sizes less than http://aims.cuhk.edu.hk/converis/portal/Publication/30 mm were selected for minimal inhibitory concentration determination by agar dilution, gyrA gene amplication and sequencing the amplified gyrA gene. Results: The prevalence of levofloxacin-resistant H. pylori was 11.5% (22/191). Among these levofloxacin-resistant strains, 7 (31.8%) and 10 (45.5%) were resistant to clarithromycin and metronidazole, respectively, 17 (77.3%) had point mutations in gyrA gene at amino acids 87, 91 and 1http://aims.cuhk.edu.hk/converis/portal/Publication/30 and the most frequent mutation point was at position 91. Conclusions: Amoxicillin, tetracycline and telithromycin were active against levofloxacin-resistant H. pylori and levofloxacin resistance was mainly due to point mutation in the gyrA gene, especially at amino acid position 91. Copyright (C) 2007 S. Karger AG, Basel.
着者Lee CC, Lee VWY, Chan FKL, Ling TKW
期刊名称Chemotherapy
出版年份2008
月份1
日期1
卷号54
期次1
出版社KARGER
页次50 - 53
国际标準期刊号0009-3157
语言英式英语
关键词antimicrobial susceptibility; Helicobacter pylori; levofloxacin
Web of Science 学科类别Oncology; ONCOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
