Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周柽森教授 (药剂学院) |
| 印绮平教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1592/phco.26.6.790 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/9Scopus source URL
其它资讯
摘要Study Objective. To characterize the population pharmacokinetics of cyclosporine in Chinese patients undergoing cardiac transplantation and to identify the demographic and clinical covariates affecting cyclosporine clearance. Design. Population pharmacokinetic analysis using data from a retrospective chart review. Setting. Specialty hospital in Hong Kong for treatment of cardiac and pulmonary diseases. Patients. Thirty-eight Chinese adult patients (mean age 46 yrs) who had undergone routine cyclosporine therapeutic drug monitoring after cardiac transplantation between January 1, 1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/91, and December 31, 2003. Measurements and Main Results. Data regarding dosing, demographics, clinical laboratory values, and concurrent drugs were collected retrospectively. Data were included if patients had blood cyclosporine concentrations determined for at least 12 weeks after transplantation; an average of 18 blood samples/patient were collected. Population modeling was performed using a one-compartment linear model with first-order absorption and elimination. Various demographic and clinical covariates were tested for their significant effects on the apparent oral clearance (Cl/F) of cyclosporine. The stability of the final population model was evaluated by using the bootstrap resampling method. Statistically significant associations were observed between Cl/F and each of the following covariates: body weight (BW), use of diltiazem (DIL), and hematocrit value (HCT). The final model was Cl/F = 5.00 · (1 - DIL) + 365/HCT + (0.144 · BW). The interindividual variabilities of Cl/F and apparent volume of distribution were 14.5% and 40.2%, respectively. The mean parameter estimates obtained from bootstrap analyses were highly consistent with those obtained with the original data set. Conclusion. The estimated Cl/F values of cyclosporine in our Chinese cardiac transplant recipients appeared to be similar to those reported for Caucasian cardiac transplant recipients. Thus, our data provide support that a cyclosporine dosage regimen similar to that in Caucasian patients may be needed in Chinese cardiac transplant recipients. However, further studies are required to determine the optimum cyclosporine dosage regimen in the Chinese population.
着者Yin O.Q.P., Lau S.-K., Chow M.S.S.
期刊名称Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
出版年份2006
月份6
日期1
卷号26
期次6 I
出版社American College of Clinical Pharmacy
出版地United States
页次http://aims.cuhk.edu.hk/converis/portal/Publication/7http://aims.cuhk.edu.hk/converis/portal/Publication/90 - http://aims.cuhk.edu.hk/converis/portal/Publication/7http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/7
国际标準期刊号02http://aims.cuhk.edu.hk/converis/portal/Publication/7http://aims.cuhk.edu.hk/converis/portal/Publication/7-0008
电子国际标準期刊号18http://aims.cuhk.edu.hk/converis/portal/Publication/75-http://aims.cuhk.edu.hk/converis/portal/Publication/9114
语言英式英语
关键词Cardiac transplantation, Cyclosporine, Drug monitoring, NONMEM software, Population pharmacokinetics
