Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 包立怡教授 (药剂学院) |
全文
| 没有全文档案提供 |
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Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/0Scopus source URL
其它资讯
摘要More women than men have Alzheimer's disease (AD). Longer duration of disease, less vascular dementia, and less testosterone in women than men may contribute to this disparity, but longer life span of women than men may be the largest factor. Retrospective studies suggested that hormone replacement therapy (HRT) might counteract this disparity by reducing the risk of developing dementia. However, a large, prospective study revealed the puzzling result that HRT increased dementia risk. Various mechanisms might produce this increase: greater risk of strokes, leading to dementia; use of medroxyprogesterone acetate and estrone, which might have somewhat different possible effects on neuronal and cerebrovascular function than may progesterone and estradiol; decrease of free testosterone which might protect against AD; a dose or delivery method perhaps producing drug levels that might lie outside a hypothetical beneficial range; and down-regulation of estrogen receptors on cholinergic neurons, possibly reducing cholinergic activity.
着者Baum L.
期刊名称Research and Practice in Alzheimer's Disease
详细描述ed. by B. Vellas, B. Winblad, M. Grundman, L.J. Fitten, H. Feldman, E. Giacobini.
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/06
月份12
日期1
卷号11
出版社SERDI Publisher
出版地France
页次98 - 1http://aims.cuhk.edu.hk/converis/portal/Publication/02
国际标準书号2914377959
国际标準期刊号1284-836http://aims.cuhk.edu.hk/converis/portal/Publication/0
语言英式英语
关键词Alzheimer's disease, Estrogen, Hormone replacement therapy, Hormones, Progesterone
