Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周喜林教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/jps.20426 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/88WOS source URL
其它资讯
摘要Modified disodium cromoglycate powders were prepared by co-spray drying with different concentrations of leucine, phenylalanine, tryptophan, methionine, asparagine, and arginine. Amorphous spherical particles of the same size and density where obtained which, however, exhibited different surface properties as measured by the inverse gas chromatography (IGC) and X-ray photoelectron spectroscopy (XPS) techniques. The surface energy parameters, such as the dispersive component of surface D free energy of the sample, gamma s(D), and the total solubility parameter, delta, were significantly lower in the presence of nonpolar chain amino acids, particularly with leucine and phenylalanine, than pure DSCG. However no quantitative relationship between these parameters, the additive concentrations, and the fine particle fractions, FPF, determined for different inhalers and air flow rates, was observed. The FPF significantly increased with addition of leucine and this effect was attributed to reduced intermolecular interactions between leucine and disodium cromoglycate molecules, as indicated by the difference in corresponding Hansen solubility parameters. Decrease of interparticle interactions for leucine-containing powders also led to a lesser dependence of FPF on the flow rate and inhaler type. (c) 2005 Wiley-Liss, Inc.
着者Chew NYK, Shekunov BY, Tong HHY, Chow AHL, Savage C, Wu J, Chan HK
期刊名称JOURNAL OF PHARMACEUTICAL SCIENCES
出版年份2005
月份10
日期1
卷号94
期次10
出版社JOHN WILEY & SONS INC
页次2289 - 2300
国际标準期刊号0022-3549
电子国际标準期刊号1520-6017
语言英式英语
关键词dry powder aerosols; emitted dose; fine particle fraction; leucine; surface energy
Web of Science 学科类别Chemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
