Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 张丽群博士 (那打素护理学院) |
| 叶碧瑶教授 (微生物学系) |
| 许明媚教授 (微生物学系) |
| 吴浩强教授 (病理解剖及细胞学系) |
| 陈基湘教授 (微生物学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/(SICI)1096-9071(199912)59:4<491::AID-JMV11>3.0.CO;2-1 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/31WOS source URL
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摘要The three novel human herpesviruses (HHV) 6, 7, and 8 are predominantly, but not exclusively, lymphotropic. In an attempt to elucidate their neurotropism in vivo, viral DNA sequences present in fresh autopsy cortical brain tissues obtained from 84 consecutive Chinese subjects (mean age, 66.9 years; range, 21-98 years) were detected by a nested polymerase chain reaction. These patients were apparently immunocompetent and free of clinical signs of viral diseases. HHV-6 DNA was detected in 36 of 84 (42.9%) patients, and the DNA-positive and -negative groups did not show a significant difference in age or sex distribution. Of the 36 HHV-6 DNA-positive cases, 9 (25%) were variant A and 27 (75%) were variant B. In view of the lower prevalence of variant A than variant B in the adult population, the two variants may share a comparable neuroinvasive potential. HHV-7 and HHV-8 DNA were detected respectively in three and two patients. The low positive rates of HHV-7 and HHV-8 may represent a relatively lower neuroinvasive potential of: the viruses. Alternatively, the localization of HHV-7 and HHV-8 may be more restricted and the sampled cortical tissues may not represent the most abundant site of persistence in the nervous system. The results provide molecular evidence of the presence of the three newly identified herpesviruses in brain tissue. The pathogenic role for HHV-7 and HHV-8, as with HHV-6, in neurological diseases should not be overlooked. (C) 1999 Wiley-Liss, Inc.
着者Chan PKS, Ng HK, Hui MM, Ip M, Cheung JLK, Cheng AF
期刊名称Journal of Medical Virology
出版年份1999
月份12
日期1
卷号59
期次4
出版社WILEY-LISS
页次491 - 495
国际标準期刊号0146-6615
电子国际标準期刊号1096-9071
语言英式英语
关键词nervous system; neuroinvasion; neurotropism; PCR; persistence
Web of Science 学科类别Virology; VIROLOGY
