Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/cpr.12225 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
其它资讯
摘要Keloids are defined as benign dermal scars invading adjacent healthy tissue, characterized by aberrant fibroblast dynamics and overproduction of extracellular matrix. However, the aetiology and molecular mechanism of keloid production remain poorly understood. Recent discoveries have shed new light on the involvement of a class of noncoding RNAs known as microRNAs (miRNA), in keloid formation. A number of miRNAs have differential expression in keloid tissues and keloid-derived fibroblasts. These miRNAs have been characterized as novel regulators of cellular processes pertinent to wound healing, including extracellular matrix deposition and fibroblast proliferation. Delineating the functional significance of miRNA deregulation may help us better understand pathogenesis of keloids, and promote development of miRNA-directed therapeutics against this condition.
着者Yu X, Li Z, Chan MTV, Wu WKK
期刊名称Cell Proliferation
出版年份201http://aims.cuhk.edu.hk/converis/portal/Publication/5
月份12
日期1
卷号48
期次6
出版社WILEY-BLACKWELL
页次626 - 630
国际标準期刊号0960-7722
电子国际标準期刊号136http://aims.cuhk.edu.hk/converis/portal/Publication/5-2184
语言英式英语
Web of Science 学科类别Cell Biology
