Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/cpr.12180 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/39WOS source URL
其它资讯
摘要Aetiology of intervertebral disc degeneration (IDD) is complex, with genetic, developmental, biochemical and biomechanical factors contributing to the disease process. It is becoming obvious that epigenetic processes influence evolution of IDD as strongly as the genetic background. Deregulated phenotypes of nucleus pulposus cells, including differentiation, migration, proliferation and apoptosis, are involved in all stages of progression of human IDD. Non-coding RNAs, including microRNAs, have recently been recognized as important regulators of gene expression. Research into roles of microRNAs in IDD has been very active over the past 5years. Our review summarizes current research enlightenment towards understanding roles of microRNAs in regulating nucleus pulposus cell functions in IDD. These exciting findings support the notion that specific modulation of microRNAs may represent an attractive approach for management of IDD.
着者Li Z, Yu X, Shen JX, Chan MTV, Wu WKK
期刊名称Cell Proliferation
出版年份2015
月份6
日期1
卷号48
期次3
出版社WILEY-BLACKWELL
页次278 - 283
国际标準期刊号0960-7722
电子国际标準期刊号1365-2184
语言英式英语
Web of Science 学科类别Cell Biology
