Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
| 于君教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/cpr.12202 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/15WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/16Scopus source URL
其它资讯
摘要Colorectal cancer (CRC) is the fourth leading cause of cancer-related death globally. Chemotherapy regimens consisting of 5-fluorouracil (5-FU) in combination with either oxaliplatin or irinotecan are the first-line options for treatment of metastatic CRC. However, primary or acquired resistance to these chemotherapeutics is a major clinical challenge. MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression post-transcriptionally. miRNAs play important roles in many cancer-related processes, including cell proliferation, apoptosis and invasion, and their dysregulation is implicated in colorectal tumourigenesis. Pertinent to chemotherapy, increasing evidence has revealed that miRNAs can be directly linked to chemosensitivity in CRC. In this review, we summarize current evidence concerning the role of miRNAs in prediction and modulation of cellular responses to 5-FU, oxaliplatin and irinotecan in CRC. We also discuss the possible targets and intracellular pathways involved in these processes.
着者Yu X., Li Z., Yu J., Chan M.T.V., Wu W.K.K.
期刊名称Cell Proliferation
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/15
月份10
日期1
卷号48
期次5
出版社Blackwell Publishing Inc.
出版地United Kingdom
页次503 - 510
国际标準期刊号0960-7722
电子国际标準期刊号1365-2184
语言英式英语
