Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3727/096504015X14424348426116 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
其它资讯
摘要TIP30/CC3 was first identified and characterized as a "candidate" tumor-suppressor gene in http://aims.cuhk.edu.hk/converis/portal/Publication/1997. Recently, the TIP30 tumor-suppressor status has been fully established since several studies have described that TIP30 protein expression is frequently downregulated in diverse types of human tumors, and the downregulation is often associated with tumor progression. TIP30 is involved in the control of cell apoptosis, growth, metastasis, angiogenesis, DNA repair, and tumor cell metabolism. Moreover, TIP30(-/-) mice spontaneously develop hepatocellular carcinoma and other tumors at a higher incidence than that of wild-type mice. In this review, we provide an overview of current knowledge concerning the role of TIP30 in tumor development and progression. To our knowledge, this is the first review about the role of novel tumor-suppressor gene TIP30 in tumor development and progression.
着者Yu X, Li Z, Wu WKK
期刊名称Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/15
月份http://aims.cuhk.edu.hk/converis/portal/Publication/1
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号22
期次5-6
出版社COGNIZANT COMMUNICATION CORP
页次339 - 348
国际标準期刊号0965-0407
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1555-3906
语言英式英语
关键词Cancer; TIP30; Tumor-suppressor gene (TSG)
Web of Science 学科类别Oncology
