Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 曹之宪教授 (生物医学学院) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 罗晓敏先生 (生物医学学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.lfs.2014.04.036 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/3Scopus source URL
其它资讯
摘要Inflammation and cancer are the two major disorders in the gastrointestinal tract. They are causally related in their pathogenesis. It is important to study animal models' causal relationship and, in particular, to discover new therapeutic agents for such diseases. There are several criteria for these models in order to make them useful in better understanding the etiology and treatment of the said diseases in humans. In this regard, animal models should be similar as possible to human diseases and also be easy to produce and reproducible and also economic to allow a continuous replication in different laboratories. In this review, we summarize the various animal models for inflammatory and cancerous disorders in the upper and lower gastrointestinal tract. Experimental approaches are as simple as by giving a single oral dose of alcohol or other noxious agents or by injections of multiple dosages of ulcer inducing agents or by parenteral administration or in drinking water of carcinogens or by modifying the genetic makeups of animals to produce relatively long-term pathological changes in particular organs. With these methods they could induce consistent inflammatory responses or tumorigenesis in the gastrointestinal mucosa. These animal models are widely used in laboratories in understanding the pathogenesis as well as the mechanisms of action for therapeutic agents in the treatment of gastrointestinal inflammation and cancer. ? 20http://aims.cuhk.edu.hk/converis/portal/Publication/14 Elsevier Inc.
着者Lu L., Chan R.L.Y., Luo X.M., Wu W.K.K., Shin V.Y., Cho C.H.
期刊名称LIFE SCIENCES
详细描述To ORKTS: Prof. C.H. Cho is the corresponding author.
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/14
月份7
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/108
期次http://aims.cuhk.edu.hk/converis/portal/Publication/1
出版社Elsevier BV
出版地Netherlands
页次http://aims.cuhk.edu.hk/converis/portal/Publication/1 - 6
国际标準期刊号0024-http://aims.cuhk.edu.hk/converis/portal/Publication/3205
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1879-06http://aims.cuhk.edu.hk/converis/portal/Publication/3http://aims.cuhk.edu.hk/converis/portal/Publication/1
语言英式英语
关键词Animal models, Cancer, Gastrointestinal diseases, Inflammation
