Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Manoj Kumar KARMAKAR (麻醉及深切治疗学系) |
| 何名熙教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.amjsurg.2005.03.034 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/112WOS source URL
其它资讯
摘要Hemorrhage is a major cause of trauma deaths. Coagulopathy exacerbates hemorrhage and is commonly seen during major trauma resuscitation, suggesting that current practice of coagulation factor transfusion is inadequate. Reversal of coagulopathy involves normalization of body temperature, elimination of the causes of disseminated intravascular coagulation (DIC), and transfusion with fresh-frozen plasma (FFP), platelets, and cryoprecipitate. Transfusion should be guided by clinical factors and laboratory results. However, in major trauma, clinical signs may be obscured and various factors conspire to make it difficult to provide the best transfusion therapy. Existing empiric transfusion strategies for, and prevailing teachings on, FFP transfusion appear to be based on old studies involving elective patients transfused with whole blood and may not be applicable to trauma patients in the era of transfusion with packed red blood cells (PRBCs). Perpetuation of such concepts is in part responsible for the common finding of refractory coagulopathy in major trauma patients today. In this review, we argue that coagulopathy can best be avoided or reversed when severe trauma victims are transfused with at least the equivalent of whole blood in a timely fashion. (c) 2005 Excerpta Medica Inc. All rights reserved.
着者Ho AMH, Karmakar MK, Dion PW
期刊名称American Journal of Surgery
出版年份2005
月份9
日期1
卷号190
期次3
出版社EXCERPTA MEDICA INC
页次479 - 484
国际标準期刊号0002-9610
电子国际标準期刊号1879-1883
语言英式英语
关键词acidosis; blood coagulation factors; disseminated intravascular coagulation; hemorrhage; hypothermia; plasma; transfusion; wounds and injuries
Web of Science 学科类别Surgery; SURGERY
