Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 陈德威教授 (麻醉及深切治疗学系) |
| 潘伟生教授 (外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/3-211-32318-X-2 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/13Scopus source URL
其它资讯
摘要Ischaemic brain damage has been shown to be an important contributing factor causing head injury fatality. Maintenance of an adequate cerebral perfusion pressure is difficult in patients with elevated intracranial pressure (ICP) and deranged cerebral vasoreactivity. Thirty-five cases of ventilated moderate-to-severe head-injured patients were prospectively studied, correlating their cerebral haemodynamic abnormalities, neurochemical disturbances (using microdialysis methodology) and clinical outcome. Cerebral haemodynamic abnormalities were defined and classified by transcranial Doppler ultrasonography (TCD) and stable xenon-CT cerebral blood flow measurements (XeCT) into their status of CO2 reactivity, pressure autoregulation, hyperaemia or non-hyperaemia. Two-hour episodes of these abnormalities with and without haemodynamic intervention were followed in their changes in ICP, CPP, intracerebral metabolites and finally their clinical outcome. Loss of CO 2 reactivity was associated with a significantly higher ICP, increasing intracerebral metabolites (lactate, glutamate and glycerol) and invariably a fatal outcome. Impaired pressure autoregulation was also associated with an elevated ICP, but no significant difference in intracerebral metabolites and incidence of favourable clinical outcome. Patients with intact CO2 reactivity and impaired pressure autoregulation were treated with an elevated CPP in 32 episodes, resulting in a significant reduction in ICP, intracerebral glutamate and glycerol and non-survival. In patients with intact CO2 reactivity and impaired pressure autoregulation, eleven episodes of hyperaemia were identified by XeCT. A modest 20% blood pressure reduction resulted in a trend towards a reduction of ICP, intracerebral glutamate and glycerol and non-survival. The need for haemodynamic intervention in this group of ventilated patients with moderate-to-severe head inury can be made logical when these abnormalities are identified daily. The success of management was reflected by a stable or improved ICP, CPP, intracerebral metabolic deranagement and survival. ? 2005 Springer-Verlag.
着者Poon W.S., Ng S.C.P., Chan M.T.V., Lam J.M.K., Lam W.W.M.
详细描述ed. by W.S. Poon, C.J.J. Avezaat, M.T.V. Chan, M. Czosnyka, K.Y.C. Goh, P.J.A. Hutchinson, Y. Katayama, J.M.K. Lam, A. Marmarou, S.C.P. Ng, and J.D. P
出版年份2005
月份12
日期1
期次95
出版社Springer Verlag
出版地Germany
页次9 - 11
国际标準书号9783211243367
国际标準期刊号0065-1419
语言英式英语
关键词cerebral perfusion pressure, Head injury, intracranial pressure, microdialysis
