Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| Professor Tony GIN (麻醉及深切治疗学系) |
| 潘伟生教授 (外科学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/3-211-32318-X-23 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/18Scopus source URL
其它资讯
摘要We evaluated the effects of magnesium sulfate on brain tissue oxygen (PtO2) tension, carbon dioxide (PtCO2) tension and pH (pHt) in patients undergoing temporary artery occlusion for clipping of cerebral aneurysm. We studied http://aims.cuhk.edu.hk/converis/portal/Publication/18 patients with aneurysmal subarachnoid hemorrhage. All patients received standard anesthetics using target controlled infusion of propofol (3 μg/ml) and remifentanil (10 ng/ml). After craniotomy, a calibrated multiparameter sensor (Neurotrend, Diametrics Medical, Minneapolis, MN) was inserted to measure PtO2, PtCO2 and pHt in tissue at risk of ischemia during temporary artery occlusion. Patients were then randomly allocated to receive either intravenous saline or magnesium 20 mmol over 10 min followed by an infusion 4 mmol/h. Plasma magnesium concentration, brain tissue gases and pHt were determined at baseline, 30 min after study drug infusion and 4 min after temporary clipping. Data were analyzed by factorial ANOVA with repeated measures. Intergroup difference was compared with unpaired t test. P value < 0.05 was considered significant. Patient characteristics, baseline brain tissue gases and pHt did not differ between groups. Magnesium infusion increased PtO2 by 34%. Following temporary artery occlusion, PtO2 and pHt decreased and PtCO2 increased in both groups. However, tissue hypoxia was less severe and the rate of PtO2 decline was slower in the magnesium group. Our data suggested that magnesium enhances tissue oxygenation and attenuates hypoxia during temporary artery occlusion. ? 2005 Springer-Verlag.
着者Chan M.T.V., Boet R., Ng S.C.P., Poon W.S., Gin T.
详细描述ed. by W.S. Poon, C.J.J. Avezaat, M.T.V. Chan, M. Czosnyka, K.Y.C. Goh, P.J.A. Hutchinson, Y. Katayama, J.M.K. Lam, A. Marmarou, S.C.P. Ng, and J.D. P
出版年份2005
月份12
日期1
期次95
出版社Springer Verlag
出版地Germany
页次107 - 111
国际标準书号9783211243367
国际标準期刊号0065-1419
语言英式英语
关键词Cerebral ischemia, cerebral oxygenation, magnesium, neuroprotection
