Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Manoj Kumar KARMAKAR (麻醉及深切治疗学系) |
| 何名熙教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/bja/aei263 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/12WOS source URL
其它资讯
摘要Dexmedetomidine is an alpha(2)-adrenoreceptor agonist that, in spite of its potent sedative, amnesic, and analgesic properties, has minimal respiratory depressant effect. Even at doses adequate for general anaesthesia, it does not cause central apnoea. Thus, it has been claimed that 'combining alpha(2)-agonists with opiate narcotics or non-steroidal anti-inflammatory drugs can enhance the analgesic efficacy without increasing the respiratory depressant effect of the latter' and 'the combination of alpha(2)-adrenoceptor agonists with opioids does not lead to further ventilatory depression'. We present a case of central apnoea after general anaesthesia that included opioids and dexmedetomidine, and remind the readers that in susceptible patients, dexmedetomidine may cause life-threatening respiratory depression through potentiation of co-administered central nervous system depressants.
着者Ho AMH, Chen S, Karmakar MK
期刊名称British Journal of Anaesthesia
出版年份2005
月份http://aims.cuhk.edu.hk/converis/portal/Publication/12
日期1
卷号95
期次6
出版社OXFORD UNIV PRESS
页次773 - 775
国际标準期刊号0007-09http://aims.cuhk.edu.hk/converis/portal/Publication/12
电子国际标準期刊号1471-6771
语言英式英语
关键词agonists, alpha(2)-adrenergic; complications, apnoea; complications, respiratory failure; dexmedetomidine; opiates, premedication
Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY
