Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 吕爱兰教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1161/CIRCRESAHA.115.307202 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/6Scopus source URL
其它资讯
摘要Rationale: Unraveling the developmental origin of cardiac fat could offer important implications for the treatment of cardiovascular disease. The recent identification of the mesothelial source of epicardial fat tissues reveals a heterogeneous origin of adipocytes in the adult heart. However, the developmental origin of adipocytes inside the heart, namely intramyocardial adipocytes, remains largely unknown. Objective: To trace the developmental origin of intramyocardial adipocytes. Methods and Results: In this study, we identified that the majority of intramyocardial adipocytes were restricted to myocardial regions in close proximity to the endocardium. Using a genetic lineage tracing model of endocardial cells, we found that Nfatc1+ endocardial cells contributed to a substantial number of intramyocardial adipocytes. Despite the capability of the endocardium to generate coronary vascular endothelial cells surrounding the intramyocardial adipocytes, results from our lineage tracing analyses showed that intramyocardial adipocytes were not derived from coronary vessels. Nevertheless, the endocardium of the postnatal heart did not contribute to intramyocardial adipocytes during homeostasis or after myocardial infarction. Conclusions: Our in vivo fate-mapping studies demonstrated that the developing endocardium, but not the vascular endothelial cells, gives rise to intramyocardial adipocytes in the adult heart.
着者Zhang H., Pu W., Liu Q., He L., Huang X., Tian X., Zhang L., Nie Y., Hu S., Lui K.O., Zhou B.
期刊名称Circulation Research
出版年份201http://aims.cuhk.edu.hk/converis/portal/Publication/6
月份1
日期22
卷号118
期次2
出版社Lippincott Williams & Wilkins Ltd.
出版地United States
页次254 - 2http://aims.cuhk.edu.hk/converis/portal/Publication/65
国际标準期刊号0009-http://aims.cuhk.edu.hk/converis/portal/Publication/7330
电子国际标準期刊号1524-45http://aims.cuhk.edu.hk/converis/portal/Publication/71
语言英式英语
关键词adipocytes, endocardium, endothelial cells, homeostasis, pericardium
