Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄振国教授 (化学病理学系) |
| 梁廷勋教授 (儿科学系) |
| 韩锦伦教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3390/molecules21060753 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Background: Atopic eczema is a common childhood disease associated with high IgE and eosinophilia. We characterized the clinical features associated with hyper-IgE (defined as IgE > 2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0 IU/L) in eczema. Methods: Nottingham Eczema Severity Score (NESS), family and personal history of atopy, skin prick test (SPT) for common food and aeroallergens, highest serum IgE ever and eosinophil counts were evaluated in 33http://aims.cuhk.edu.hk/converis/portal/Publication/0 children eczema patients. Childhood-NESS (NESS performed at < 1http://aims.cuhk.edu.hk/converis/portal/Publication/0 years of age) and adolescent-NESS (NESS performed at > 1http://aims.cuhk.edu.hk/converis/portal/Publication/0 years of age) were further analyzed. Results: IgE correlated with NESS (spearman coefficient http://aims.cuhk.edu.hk/converis/portal/Publication/0.35, p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01) and eosinophil percentage (spearman coefficient http://aims.cuhk.edu.hk/converis/portal/Publication/0.56, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01). Compared with IgE <= 2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0IU/L (n = 167), patients with hyper-IgE (n = 163) were associated with male gender (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/02); paternal atopy (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/026); personal history of atopic rhinitis (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/016); asthma (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01); dietary avoidance (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01); use of wet wrap (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01); traditional Chinese medicine use (TCM, p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01); immunomodulant use (azathioprine or cyclosporine, p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01); skin prick sensitization by dust mites (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01), cats (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/012), dogs (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/018), food (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/02); eosinophilia (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01); more severe disease during childhood (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01) and during adolescence (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01), but not onset age of eczema or maternal atopy. Logistic regression showed that hyper-IgE was associated with personal history of asthma (exp(B) = 5.12, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/02) and eczema severity during childhood and adolescence (p < http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01). For patients < 1http://aims.cuhk.edu.hk/converis/portal/Publication/0 years of age, dust mite sensitization (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/08) was associated with hyper-IgE. For patients > 1http://aims.cuhk.edu.hk/converis/portal/Publication/0years of age, food allergen sensitization was associated with hyper-IgE (p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/08). Conclusions: Hyper-IgE is independently associated with asthma, more severe atopy and more severe eczema during childhood and adolescence. IgE > 2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0 IU/L may be a tool to aid prognostication of this chronic relapsing dermatologic disease and its progression to asthma.
着者Ng C, Hon KL, Kung JSC, Pong NH, Leung TF, Wong CK
期刊名称MOLECULES
详细描述doi: 1http://aims.cuhk.edu.hk/converis/portal/Publication/0.339http://aims.cuhk.edu.hk/converis/portal/Publication/0/molecules21http://aims.cuhk.edu.hk/converis/portal/Publication/06http://aims.cuhk.edu.hk/converis/portal/Publication/0753.
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份6
日期1
卷号21
期次6
出版社MDPI AG
国际标準期刊号142http://aims.cuhk.edu.hk/converis/portal/Publication/0-3http://aims.cuhk.edu.hk/converis/portal/Publication/049
语言英式英语
关键词atopic dermatitis; atopy; eczema; NESS; prognosis; severity
Web of Science 学科类别Chemistry; Chemistry, Organic
