Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈君赐教授 (化学病理学系) |
| 王昭春教授 (病理解剖及细胞学系) |
| 王雅欣博士 (病理解剖及细胞学系) |
| 陈林教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.ctrv.2016.02.008 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/12Scopus source URL
其它资讯
摘要Following the approval of sorafenib, a large number of molecular targeted agents have been tested clinically for advanced hepatocellular carcinoma (HCC), but all have failed to demonstrate significant efficacy in clinical trials. Multiple reasons for this phenomenon have been discussed in the literature, with one reason being the lack of patient selection on the basis of molecular profile in clinical trials. The concept of drug testing in selected populations has been recently suggested by retrospective analyses of HCC clinical trials in which a particular subgroup of patients, either enriched by clinical factors or by tissue biomarkers, derived more benefits from the novel drug. In addition, recent advances in genomic medicine have enhanced the understanding of genetic and epigenetic events occurring in HCC, raising the possibility of personalizing targeted agents in accordance with the genetic make-up of the tumors. The development of 'personalized' treatment for HCC is, however, hindered by the lack of fresh biopsy of advanced HCC, the low incidence of genetic driver mutations in HCC and the tumor heterogeneity. These limitations may be overcome by sequencing cell-free DNA in plasma, frequently known as liquid biopsy, and revolution in the concept of the design of clinical trials. In this review article, we aim to: (1) give a summary of the recent sequencing results of HCC and the related implications for drug development; (2) highlight potential individual targeted agents and existing research on biomarker selection in clinical trials; and (3) discuss future directions, including the potential of liquid biopsy and umbrella clinical trials, to enhance personalized drug testing for HCC.
着者Chan S.L., Wong A.M., Lee K., Wong N., Chan A.K.C.
期刊名称Cancer Treatment Reviews
出版年份2016
月份4
日期1
卷号45
出版社W. B. Saunders Co., Ltd.
出版地United Kingdom
页次77 - 86
国际标準期刊号0305-7372
电子国际标準期刊号1532-1967
语言英式英语
关键词Biomarker, Drug, Liver neoplasm, Targeted therapy
