Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
Publication in refereed journal


香港中文大学研究人员 ( 现职)

吕爱兰教授 (化学病理学系)

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典藏于此文库的全文 ncomms13369.pdf 数位物件识别号 (DOI) http://dx.doi.org/10.1038/ncomms13369 出版商提供的全文 https://www.nature.com/articles/ncomms13369

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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL

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摘要Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral hepatocytes. During liver injury and regeneration, the cellular dynamics of these two distinct populations remain largely elusive. Here we show that major facilitator super family domain containing 2a (Mfsd2a), previously known to maintain blood-brain barrier function, is a periportal zonation marker. By genetic lineage tracing of Mfsd2a(+) periportal hepatocytes, we show that Mfsd2a(+) population decreases during liver homeostasis. Nevertheless, liver regeneration induced by partial hepatectomy significantly stimulates expansion of the Mfsd2a(+) periportal hepatocytes. Similarly, during chronic liver injury, the Mfsd2a(+) hepatocyte population expands and completely replaces the pericentral hepatocyte population throughout the whole liver. After injury recovery, the adult liver re-establishes the metabolic zonation by reprogramming the Mfsd2a(+)-derived hepatocytes into pericentral hepatocytes. The evidence of entire zonation replacement during injury increases our understanding of liver biology and disease.

出版社接受日期26.http://aims.cuhk.edu.hk/converis/portal/Publication/09.2http://aims.cuhk.edu.hk/converis/portal/Publication/016
着者Pu WJ, Zhang H, Huang XZ, Tian XY, He LJ, Wang Y, Zhang LB, Liu QZ, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou YQ, Huang PY, Nie Y, Yan Y, Hui LJ, Lui KO, Zhou B
期刊名称NATURE COMMUNICATIONS
详细描述Article number: 13369
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份11
日期18
卷号7
出版社NATURE PUBLISHING GROUP
电子国际标準期刊号2http://aims.cuhk.edu.hk/converis/portal/Publication/041-1723
语言英式英语

关键词MATURE HEPATOCYTES, MOUSE HEPATOCYTES, GENE-EXPRESSION, ZONATION, CELLS, HOMEOSTASIS, MECHANISM, OCCURS
Web of Science 学科类别Multidisciplinary Sciences;Science & Technology - Other Topics