Publication in refereed journal
香港中文大学研究人员 ( 现职)
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摘要Prenatal diagnosis of fetal genetic conditions is a standard part of modern obstetric care. Many of the current methods rely on invasive methods and are associated with an inherent risk of fetal loss. Consequently, there has been a long-term goal for development of noninvasive prenatal diagnostic methods. In 1997, the presence of fetal DNA in maternal plasma was first discovered through the detection of Y-chromosome-specific sequences in the plasma of women conceived with male fetuses. This discovery has opened up new possibilities in the development of noninvasive prenatal diagnostic methods through a source of fetal genetic material that could be conveniently accessible simply through the collection of a maternal peripheral blood sample. To date, there have been numerous reported applications, including fetal RhD genotyping, prenatal diagnosis of sex-linked disorders, paternally inherited genetic diseases and some pregnancy-associated conditions, including preeclampsia. More recently, there have been significant new developments with expanding number of potential applications.
着者Chiu R.W.K., Lo Y.M.D.
期刊名称Expert Review of Anticancer Therapy
出版年份2002
月份6
日期29
卷号2
期次1
出版社Future Drugs Ltd.
出版地United Kingdom
页次32 - 40
国际标準期刊号1473-7140
电子国际标準期刊号1744-8328
语言英式英语
关键词Diagnosis, Noninvasive, Plasma DNA, Prenatal, Quantitative PCR, Real-time
