Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林伟基教授 (化学病理学系) |
| 黄振国教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1081/IPH-120003748 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/19WOS source URL
其它资讯
摘要The incidence and prevalence of allergic diseases such as asthma and allergic rhinitis have recently been increasing worldwide. Eosinophils are the principal effector cells for the pathogenesis of allergic inflammation via the secretion of highly cytotoxic granular proteins including eosinophil cationic protein, major basic protein and eosinophil protein X. Blood and tissue eosinophilia is a common manifestation of late-phase allergic inflammation causing tissue damage. The development of eosinophilia correlates with the production of haematopoietic cytokines including interleukin (IL)-3, IL-5 and granulocyte macrophage colony stimulating factor (GM-CSF), and eosinophil-specific chemoattractant, eotaxin, from T-lymphocytes and the epithelium respectively. Elucidation of intracellular mechanisms that control the activation, apoptosis and recruitment of eosinophils to tissues is therefore fundamental in understanding these disease processes and provides targets for novel drug therapy. Over the past decade, there has been intensive investigation for the intracellular signal transduction regulating various biological functions of eosinophils and their roles in the pathogenesis of eosinophil-related diseases. This review will emphasize on the cytokine and chemokine-mediated signal transductions including the RAS-RAF-mitogen-activated protein kinases (MAPK), Janus kinases (JAK)-signal transducers and activators of transcription (STAT), phosphatidylinositol 3-kinase (PI3K) and nuclear factor-kappa B (NF-kappaB), and various antagonists of receptors and inhibitors of intracellular signaling molecules as potential therapeutic agents of allergic diseases.
着者Wong CK, Zhang JP, Ip WK, Lam CWK
期刊名称Immunopharmacology and Immunotoxicology
出版年份2002
月份1
日期1
卷号24
期次2
出版社INFORMA HEALTHCARE
页次165 - 186
国际标準期刊号0892-3973
语言英式英语
关键词eosinophils; eotaxin; GM-CSF; IL-3; IL-5; JAK; MAPK; NF-kappa B; PI3K; STAT
Web of Science 学科类别Immunology; IMMUNOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Toxicology; TOXICOLOGY
