Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 陈君赐教授 (化学病理学系) |
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| 没有全文档案提供 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/14WOS source URL
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摘要Patients suffering from malignant diseases have been shown to have increased amounts of cell free nucleic acids in their circulation. As genetic and epigenetic alterations are increasingly characterized in different types of tumors, such changes can be used to detect tumor-derived nucleic acids in the circulation. To date, nearly all tumor-associated nucleic acids have been detected in the plasma or serum of cancer patients. Moreover, increased levels of circulating viral nucleic acids have also been demonstrated in patients with certain cancers associated with viral infections. The concentration of these tumor-associated nucleic acid species is generally related to the tumor load and the extent of the disease. Serial monitoring of plasma nucleic acids thus provides a good way to follow, disease progress and to predict the outcome of such patients. In this review, different approaches of detecting tumor-related nucleic acids in the circulation and their potential as tumor markers in the screening, monitoring and prognostication of malignant diseases are discussed.
着者Chan KCA, Lo YMD
期刊名称HISTOLOGY AND HISTOPATHOLOGY
出版年份2002
月份7
日期1
卷号17
期次3
出版社F HERNANDEZ
页次937 - 943
国际标準期刊号0213-3911
语言英式英语
关键词cancer; circulating nucleic acids; plasma/serum DNA; tumor markers
Web of Science 学科类别Cell Biology; CELL BIOLOGY; Pathology; PATHOLOGY
