Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 杜家辉教授 (病理解剖及细胞学系) |
| 雷兆辉教授 (赛马会公共卫生及基层医疗学院) |
| 邓亮生教授 (化学病理学系) |
| 李锦滔教授 |
| 司徒卓俊教授 (内科及药物治疗学系) |
| 黎永祥教授 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1053/ajkd.2000.17614 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/21WOS source URL
其它资讯
摘要Histological grading of 45 patients with clinical early immunoglobulin A (IgA) nephropathy was correlated with disease progression over a median follow-up of 123 months. Clinical early IgA nephropathy was defined as a serum creatinine level of 1.3 mg/dL or less, proteinuria of 0.4 g/d or less of protein, and the absence of hypertension at the time of renal biopsy, Disease progression was related to the occurrence of impaired renal function, increased proteinuria, and hypertension. We applied a previously described chronicity-based histological grading to the renal biopsy specimen and also assessed acute glomerular lesions. Disease progression was observed in 44.4% of these patients. Forty patients (89%) showed glomerular grade 1 (GG1) and 5 patients (11%) showed GG2, but this grading did not correlate with disease progression. However, when GG1 was subdivided into GG1a (mean sclerosis per glomerulus <10%) and GG1b (mean sclerosis per glomerulus 1(10% to <25%), GG1a correlated with nonprogressive disease. Tubulointerstitial grade also correlated with disease progression but was associated with a low sensitivity for predicting nonprogressive disease. Hyaline arteriolosclerosis and acute glomerular lesions did not correlate with disease progression. The chronicity-based histological grading is not only applicable to clinical early IgA nephropathy, but also more importantly, it characterizes GG1a in a subset of patients with a very low risk for disease progression, which can be regarded as genuine early IgA nephropathy, (C) 2000 by the National Kidney Foundation, Inc.
着者Lai FMM, Szeto CC, Choi PCL, Li PKT, Chan AWH, Tang NLS, Lui SF, Wang AYM, To KF
期刊名称American Journal of Kidney Diseases
出版年份2000
月份10
日期1
卷号36
期次4
出版社W B SAUNDERS CO
页次703 - 708
国际标準期刊号0272-6386
电子国际标準期刊号1523-6838
语言英式英语
关键词disease progression; early disease; histological grading; immunoglobulin A (IgA) nephropathy
Web of Science 学科类别Urology & Nephrology; UROLOGY & NEPHROLOGY
