Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
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| 没有全文档案提供 |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/20WOS source URL
其它资讯
摘要Recently, cell-free fetal DNA has been found in maternal plasma and serum. This discovery opens up a new field of investigation and provides an easily accessible source of fetal genetic material for prenatal diagnosis. Prenatal diagnostic applications of fetal DNA in maternal plasma include the investigation of sex-linked disorders and fetal rhesus D status determination. Cell-free fetal DNA has been found to be present in much higher fractional concentrations than fetal nucleated cells in maternal blood. The concentration of fetal DNA increases throughout pregnancy, with a sharp rise towards the end of gestation. Abnormally high levels of cell-free DNA have been found in pregnancies complicated by preeclampsia and preterm labor, an observation that has potential diagnostic and pathophysiologic implications. Much remains to be learned regarding the mechanisms of production and clearance of maternal plasma fetal DNA. It is hoped that the eagerly awaited answers to these and other questions may ultimately enhance our understanding of the fetomaternal relationship.
着者Lo YMD
会议名称1st International Symposium on Circulating Nucleic Acids in Plasma/Serum
会议开始日18.08.1999
会议完结日http://aims.cuhk.edu.hk/converis/portal/Publication/20.08.1999
会议地点MENTHON ST BERNARD
期刊名称Annals of the New York Academy of Sciences
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/2000
月份1
日期1
卷号906
出版社NEW YORK ACAD SCIENCES
页次141 - 147
国际标準书号1-57331-269-X
国际标準期刊号0077-8923
电子国际标準期刊号1749-6632
语言英式英语
Web of Science 学科类别Medical Laboratory Technology; Multidisciplinary Sciences; Oncology; Science & Technology - Other Topics
